VITAMINA E 400 UI
| Marca inregistrata (ADM): Vitamina E d-alfa tocoferil acetat
din germeni de griu, sursa naturala de Vitamina E |
 |
3. VITAMINA
E 400 UI antioxidant cu concentretie inalta in tratamentul sistemului nervos
central
Celula umana: Structura
|
 |
4. Teoria
radicalilor liberi in procesul de imbatrinire
Densitatea de neutralizare a radicalilor
liberi
Celula este distrusa prin radicalii liberi:
Capacitate scazuta de neutralizare a radicalilor liberi
|
 |
Suficienti antioxidanti de recomandat: Acid alfa
lipoic, Ceai Verde, Vitamina C, Glutation, Vitamin E, Carotenoizi,
Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza
(SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H2O2)
si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari
Capacitate suficienta de neutralizare a radicalilor liberi
|
 |
| Antioxidantii neutralizeaza radicali liberi |
 |
Formarea de radicali liberi
|
|
|
5. Vitamina
E si Vitamina A ca supliment nutritiv in retinita pigmentara
6. Vitamina
E in preinfarct miocardic si dupã infarct miocardic, studiu randomizat,
dublu-orb, placebo controlat.
7. Vitamina
E in tratamentul pentru prevenirea bolilor cardiovasculare, meta
analiza si
studiu randomizat, dublu-orb, placebo controlat.
8. Vitamina
E reduce oxidarea lipoproteinelor cu densitate joasa
LDL
9. Vitamina
E creste concentratia plasmatica a lipoproteinelor cu densitate
inalta (colesterolul-HDL)
si scade nivelul de trigliceride
10. Vitamina
E ca supliment nutritiv indicat pentru intarirea sistemului
imunitar
11. Vitamina
E ca supliment nutritiv indicat pentru prevenirea cancerului de prostata
12. Vitamina
E inhiba cresterea de melanom malign
13. Vitamina
E sprijina mentinerea intro faza de dormire a cancerului mamar
14. Vitamina
E indicat pentru prevenirea cancerului de plamin
15. Vitamina
E si Vitamina C antioxidanti indicat in tratamentul de Alzheimer sau declin
cognitiv,
studiu randomizat, dublu-orb, placebo controlat.
16. Efectul de suplimente nutritionale de Vitamina
E asupra concentratiei de pigmenti de lipofuscina pe cerebral
17. Vitamina
E antioxidant indicat in tratamentul de Parkinson
18. Beneficiul
de Vitamina
E ca supliment nutritiv in rezistenta la exercitiul fizic
19. Vitamina
E cu efect in tratamentele sezonale de rinita alergica
| Bibliografie-Referinte: |
 |
1. Cherubini A, Zuliani G, Costantini
F,
et al. High
vitamin E plasma levels and low low-density lipoprotein oxidation are associated
with the absence of atherosclerosis in octogenarians. J Am Geriatr Soc.
2001;49(5):651-654.
- Gale CR, Ashurst HE, Powers HJ, Martyn CN. Antioxidant
vitamin status and carotid atherosclerosis in the elderly. Am J Clin Nutr.
2001;74(3):402-408.
2. A
randomized, placebo-controlled, clinical trial of high-dose supplementation
with vitamins C and E and beta carotene for age-related cataract and vision
loss: AREDS report no. 9. Arch Ophthalmol. 2001;119(10):1439-1452.
- Teikari JM, Rautalahti M, Haukka J, et al. Incidence
of cataract operations in Finnish male smokers unaffected by alpha tocopherol
or beta carotene supplements. J Epidemiol Community Health. 1998;52(7):468-472.
-
Jacques PF. The
potential preventive effects of vitamins for cataract and age-related macular
degeneration. Int J Vitam Nutr Res. 1999;69(3):198-205.
- Gale CR, Hall NF, Phillips DI, Martyn CN. Plasma
antioxidant vitamins and carotenoids and age-related cataract. Ophthalmology.
2001;108(11):1992-1998.
Delcourt C, Cristol J-P, Tessier F, et al. Age-related macular degeneration
and antioxidant status in the POLA study. Arch Opthalmol. 1999; 117:1384-1390.
3. Vatassery GT, Bauer T, Dysken M. High
doses of vitamin E in the treatment of the central nervous system in the aged.
Amer J Clin Nutr.
1999; 70:793-801.
4. Beckman, K. & Ames, B. (1998) "The
free radical theory of aging matures" Physiol
Rev 78: 548-81.
5. Berson EL, Rosner B, Sandberg MA, et
al. A
randomized trial of vitamin A and vitamin E supplementation for retinitis
pigmentosa. Arch Ophthalmol. 1993;111(6):761-772.
6. Rapola JM, Virtamo J, Ripatti S, et
al. Randomised
trial of alpha-tocopherol and beta-carotene supplements on incidence of major
coronary events in men
with previous myocardial infarction. Lancet. 1997;349(9067):1715-1720.
- Rapola JM, Virtamo J, Ripatti S, et al. Effects of alpha-tocopherol and beta-carotene
supplements on symptoms, progression, and prognosis of angina pectoris. Heart.
1998; 79:454-458.
- Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico.
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after
myocardial
infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo
Studio
della Sopravvivenza nell'Infarto miocardico. Lancet. 1999;354(9177):447-455.
7. Vivekananthan DP, Penn MS, Sapp SK, Hsu
A, Topol EJ. Use
of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis
of randomised trials. Lancet. 2003;361(9374):2017-2023.
- Eidelman RS, Hollar D, Hebert PR, Lamas GA, Hennekens CH. Randomized
trials of vitamin E in the treatment and prevention of cardiovascular disease. Arch
Intern Med. 2004;164(14):1552-1556.
- Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ.
Randomised
controlled trial of vitamin E in patients with coronary disease: Cambridge
Heart Antioxidant Study (CHAOS). Lancet. 1996;347(9004):781-786.
- Boaz M, Smetana S, Weinstein T, et al. Secondary
prevention with antioxidants of cardiovascular disease in endstage renal disease
(SPACE): randomised placebo-controlled
trial. Lancet. 2000;356(9237):1213-1218.
- Yusuf S, Dagenais G, Pogue J, Bosch
J, Sleight P. Vitamin
E supplementation and cardiovascular events in high-risk patients. The Heart
Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342(3):154-160.
- Shekelle PG, Morton SC, Jungvig LK, et al. Effect
of supplemental vitamin E for the prevention and treatment of cardiovascular
disease. J Gen Intern Med.
2004;19(4):380-389.
Collins R, Peto R, Armitage J. The MRC/BHF Heart
Protection Study: preliminary results. Int J Clin Pract. 2002;56(1):53-56.
- Stephens NG, Parsons A, Schofield PM, et al. Randomized controlled trial of
vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study
(CHAOS). Lancet. 1996; 347:781-786.
8. Li
D, Saldeen T, Mehta JL. gamma-tocopherol
decreases ox-LDL-mediated activation of nuclear factor-kappaB and apoptosis in
human coronary artery endothelial
cells. Biochem Biophys Res Commun. 1999;259(1):157-161.
9. Reaven PD, Herold DA, Barnett J, Edelman
S. Effects
of Vitamin E on susceptibility of low-density lipoprotein and low-density lipoprotein
subfractions to oxidation and on protein glycation in NIDDM. Diabetes Care.
1995;18(6):807-816.
- Jain SK, McVie R, Jaramillo JJ, Palmer M, Smith T. Effect
of modest vitamin E supplementation on blood glycated hemoglobin and triglyceride
levels and red cell indices in type I diabetic patients. J Am Coll Nutr.
1996;15(5):458-461.
10. Meydani
SN, Meydani M, Blumberg JB,
et
al. Vitamin
E supplementation and in vivo immune response in healthy elderly subjects. A
randomized controlled trial. Jama. 1997;277(17):1380-1386.
- Han SN, Meydani SN. Vitamin
E and infectious diseases in the aged. Proc Nutr Soc. 1999;58(3):697-705.
- Hendler SS, Sanchez R. Tocopherol-based antiviral agents and method of using
same. United States Patent Number 5, 114, 957. 1992.
11. Klein EA, Thompson IM, Lippman SM,
et al. SELECT: the
next prostate cancer prevention trial. Selenum and Vitamin E Cancer Prevention
Trial. J Urol. 2001;166(4):1311-1315.
- Heinonen OP, Albanes D, Virtamo J,
et al. Prostate
cancer and supplementation with alpha-tocopherol and beta-carotene: incidence
and mortality in a controlled trial. J Natl Cancer Inst. 1998;90(6):440-446.
- Helzlsouer KJ, Huang HY, Alberg AJ,
et al. Association
between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate
cancer. J Natl Cancer Inst.
2000;92(24):2018-2023.
12. Malafa MP, Fokum FD, Mowlavi A, Abusief
M, King M. Vitamin
E inhibits
melanoma growth in mice. Surgery. 2002;131(1):85-91.
13. Malafa MP, Neitzel LT. Vitamin
E succinate promotes breast cancer tumor dormancy. J Surg Res. 2000;93(1):163-170.
14. The Alpha-Tocopherol Beta-Carotene
Cancer Prevention Study Group. The effect of vitamin E and beta-carotene on the
incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994;
330:1029-1035.
- Woodson K, Tangrea JA, Barrett MJ, et al. Serum alpha-tocopherol and subsequent
risk
of lung cancer among male smokers. J Natl Cancer Inst.
1999:91; 1738-1743.
15. Masaki KH, Losonczy KG, Izmirlian
G, et al. Association
of vitamin E and C supplement use with cognitive function and dementia in elderly
men. Neurology. 2000;54(6):1265-1272.
- Sano M, Ernesto C, Thomas RG, et al. A
controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's
disease. The Alzheimer's Disease Cooperative Study. N Engl
J Med. 1997;336(17):1216-1222.
- Meydani M. Antioxidants and cognitive function. Nutr Rev. 2001;59(8 Pt 2):S75-80;
discussion S80-72.
- Grundman M. Vitamin E and Alzheimer's disease: the basis for additional clinical
trials. Am J Clin Nutr. 2000; 71:630S-636S.
16. Csallany AS, Ayaz KL, Su LC. Effect
of dietary vitamin E and aging on tissue lipofuscin pigment concentration in
mice. J Nutr. 1977 Oct;107(10):1792-9.
17. Shoulson I. DATATOP: a decade
of neuroprotective
inquiry. Parkinson Study Group. Deprenyl
and tocopherol antioxidative therapy
of Parkinsonism.
Ann Neurol. 1998; 44(3 Suppl 1): S160-S166.
18. Takanami Y, Iwane H, Kawai Y,
Shimomitsu T. Vitamin E supplementation and endurance exercise: are there benefits
Sports Med. 2000; 29:73-83.
19. Shahar E, Hassoun G, Pollack S. Effect
of vitamin E supplementation on the regular treatment of seasonal allergic
rhinitis. Institute of Allergy, Clinical Immunology, and AIDS, Rambam
Medical Center, Haifa, Israel. ed_shahar@rambam.health.gov.il Ann Allergy
Asthma Immunol. 2004 Jun;92(6):654-8.
|
VITAMINA E 400 UI antioxidant cu concentretie inalta, reduce valorile lipoproteinelor cu densitate joasa (colesterolul-LDL), previne initierea si progresia de ateroscleroza. 
