Turmeric Curcumina
Turmeric Curcumina
Turmeric indicat la artrita reumatoida
| Turmeric indicat la artrita reumatoida |
 |
 |
Turmeric (Curcuma longa)
Regnul: Plantae - Planta
Increngatura: Traheofitelor - Planta vasculara
Subincrengatura: Spermatofita -Planta cu saminta
Clasa: Angiosperme - Monocotiledonate - Embrion
Subclasa: Zingiberidae
Ordinea: Zingiberales
Familia: Zingiberaceae
Genul: Curcuma L
Specia: Curcuma longa L. - Turmeric
|
Turmeric (Curcuma longa) cu extract standardizat de Curcumina 4%
| Curcumina: Structura chimica |
 |
| Curcumina: Formula moleculara: C21H20O6 |
| Turmeric (Curcuma longa) cu puritate si concentratie
de: Curcumina 4% |
 |
1 Turmeric (Curcuma longa) extract cu activitate antioxidativa si antitumorala.
2 Turmeric (Curcuma longa) cu activitate anti - inflamatoare si anti - artritic.
3. Turmeric
(Curcuma longa) in tratamentul de osteoartrita, studiu randomizat dublu orb
placebo controlat.
4 Turmeric
(Curcuma longa) cu activitate imunomodulatoare
5 Turmeric
(Curcuma longa) este un inhibitor de cancer
6 Turmeric
(Curcuma longa) ca agent citostatic la cancer
7 Turmeric
(Curcuma longa) cu potential anticancer, studiu clinic si preclinic
8 Turmeric
(Curcuma longa) cu potential terapeutic la cancer de prostata
9. Turmeric
(Curcuma longa) in tratamentul la cancerul hepatic
10. Turmeric
(Curcuma longa) cu efect de protectie la dauna hepatica
11 Turmeric
(Curcuma longa) induce apoptoza la celulele cancerului de colon
12 Turmeric
(Curcuma longa) induce apoptoza la scleroderma celulelor fibroblastice
13 Turmeric
(Curcuma longa) inhiba cresterea de celule tumorale la pancreas
14. Turmeric
(Curcuma longa) cu efect de inhibare a genezei tumorale
15 Turmeric
(Curcuma longa) cu efect de inhibare a angiogenezei tumorale
16. Turmeric
(Curcuma longa) cu actiune la cancer mamar
17. Turmeric
(Curcuma longa) ingredient nou in cosmetica cu potential antioxidativ, reduce
stresul oxidativ cauzate de
razele X si razele UV
| Turmeric un
produs natural pentru ingrijirea pielii |
 |
18. Turmeric
(Curcuma longa) cu potential antioxidativ de
prevenire tumorala dermala
| Turmeric (Curcuma longa) cu potential antioxidativ |
 |
19. Turmeric
(Curcuma longa) cu efect de protectie in ischemia-reperfuzia miocardica.
20 Turmeric
(Curcuma longa) are efect hipocolesterolemic si inhiba oxidarea lipidica
21. Turmeric
(Curcuma longa) cu efect in peroxidarea lipidica cauzata de fier in ficat
22 Turmeric
(Curcuma longa) cu efect la secretia de secretia de vezica biliara
23 Turmeric
(Curcuma longa) cu protectie de peroxidarea lipidica cauzata de cadmiu in
cerebral
24 Turmeric
- Curcumina cu actiune antioxidativa, si protectie cerebrala de boala
Alzheimer
| Curcumina cu protectie cerebrala de boala
Alzheimer |
 |
25 Turmeric
(Curcuma longa) inhiba cresterea de helicobacter pilori
26 Turmeric
(Curcuma longa) atenueaza colita
27 Turmeric
(Curcuma longa) cu efect antispastic
28 Turmeric
(Curcuma longa) reduce dauna mucoasei cauzate de acid tri nitro benzen sulfonic
29 Turmeric
(Curcuma longa) cu actiune de anticoagulare, inhiba agregarea plachetara
si formarea
de tromboxan
30 Turmeric
(Curcuma longa) pentru scaderea zaharului din sange este destinat persoanelor
diabetice
31 Turmeric
(Curcuma longa) cu activitate antifungala si antibacteriala
32 Turmeric
(Curcuma longa) cu continut de fenoli accelereaza vindecarea ranilor
33. Turmeric
(Curcuma longa) cu efect contraceptiv
34 Efectul de bioflavonoide Turmeric (Curcuma longa) la insuficienta
renala
| Bibliografie-Referinte: |
 |
1 Ruby AJ, Kuttan
G, Babu KD, Rajasekharan KN, Kuttan R. Anti-tumour [sic] and antioxidant activity
of natural curcuminoids. Cancer Letter. 1995;94(1):79-83.
- Odot J, Albert P,
Carlier A, Tarpin M, Devy J, Madoulet C. In vitro and in vivo anti-tumoral
effect of curcumin against melanoma cells. International
Journal of Cancer. 2004;111(3):381-387.
- Toda S, Miyase T, Arich H, et al. Natural
antioxidants. Antioxidative compounds isolated from rhizome of Curcuma longa
L. Chem Pharmacol Bull 1985;33:1725-1728.
-
Brouet I, Ohshima H. Curcumin, an anti-tumour promoter and anti-inflammatory
agent, inhibits induction of nitric oxide synthetase in activated macrophages.
Biochem Biophys Res Commun 1995;206:533-540.
- Betancor-Fernandez A, Perez-Galvez
A, Sies H, Stahl W. Screening pharmaceutical preparations containing extracts
of turmeric rhizome, artichoke leaf, devil's
claw root and garlic or salmon oil for antioxidant capacity. Journal of Pharmacy
and Pharmacology. 2003;55(7):981-986.
- Braga ME, Leal PF, Carvalho JE, Meireles
MA. Comparison of yield, composition, and antioxidant activity of turmeric
(Curcuma longa L.) extracts obtained using
various techniques. Journal of Agricultural and Food Chemistry. 2003;51(22):6604-6611.
-
Chirangini P, Sharma GJ, Sinha SK. Sulfur free radical reactivity with curcumin
as reference for evaluating antioxidant properties of medicinal zingiberales.
Journal of Environmental Pathology, Toxicology and Oncology. 2004;23(3):227-236.
-
Balasubramanyam M, Koteswari AA, Kumar RS, Monickaraj SF, Maheswari JU, Mohan
V. Curcumin-induced inhibition of cellular reactive oxygen species generation:
novel therapeutic implications. Journal of Bioscience. 2003;28(6):715-721.
-
Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, Okada S. Dietary supplementation
of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male
mice: possible role in protection against chemical carcinogenesis and toxicity.
Pharmacology and Toxicology. 2003;92(1):33-38.
- Jayaprakasha GK, Jena BS, Negi
PS, Sakariah KK. Evaluation of antioxidant activities and antimutagenicity
of turmeric oil: a byproduct from curcumin
production. Zeitschrift Fuer Naturforschung. Section C. Biosciences. 2002;57(9-10):828-835.
-
Phan TT, See P, Lee ST, Chan SY. Protective effects of curcumin against oxidative
damage on skin cells in vitro: its implication for wound healing.
Journal of
Trauma. 2001;51(5):927-931.
- Mortellini R, Foresti R, Bassi R, Green CJ. Curcumin,
an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects
endothelial
cells against oxidative
stress. Free Radic Biol Med 2000;28:1303-1312.
2 Chandra D, Gupta S. Anti-inflammatory
and anti-arthritic activity of volatile oil of Curcuma longa (Haldi). Ind J
Med Res 1972;60:138-142.
- Arora R, Basu N, Kapoor V, et al. Anti-inflammatory
studies on Curcuma longa (turmeric). Ind J Med Res 1971;59:1289-1295.
- Mukhopadhyay A, Basu N,
Ghatak N, et al. Anti-inflammatory and irritant activities of curcumin analogues
in rats. Agents Actions 1982;12:508-515.
-
Mukhopadhyay A, Basu N, Ghatak N, Gujral PK. Anti-inflammatory and irritant
activities of curcumin analogues in rats. Agents and Actions. 1982;12(4):508-515.
3. Innes JF, Fuller CJ, Grover ER, Kelly
AL, Burn JF. Randomised [sic], double-blind, placebo-controlled parallel group
study of P54FP for the treatment of dogs
with osteoarthritis. Veterinary Record. 2003;152(15):457-460.
4 Gao X, Kuo J, Jiang H, et al. Immunomodulatory
activity of curcumin: suppression of lymphocyte proliferation, development
of cell-mediated cytotoxicity, and
cytokine production in vitro. Biochemical Pharmacology. 2004;68(1):51-61.
5 Nagabhushan M, Bhide SV. Curcumin as
an inhibitor of cancer. Journal of the American College of Nutrition. 1992;11(2):192-198.
National Toxicology Program.
NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1)
(Major Component 79%-85% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1
Mice (Feed Studies). National Toxicology Program Technical Report Series. 1993;427:1-275.
6 Ireson CR, Jones DJ, Orr S, et al.
Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine.
Cancer Epidemiology, Biomarkers
and Prevention. 2002;11(1):105-111.
7. Aggarwal BB, Kumar A, Bharti AC. Anticancer
potential of curcumin: preclinical and clinical studies. Anticancer Research.
2003;23(1A):363-398.
8 Dorai
T, Cao YC, Dorai B, et al. Therapeutic potential of curcumin in human prostate
cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits
angiogenesis of LNCaP prostate cancer cells in vivo. Prostate 2001
Jun 1;47(4):293-303.
- Chendil D, Ranga RS, Meigooni D, Sathishkumar S, Ahmed MM. Curcumin confers
radiosensitizing effect in prostate cancer cell line PC-3. Oncogene. 2004;23(8):1599-1607.
- Deeb D, Jiang H, Gao X, et al. Curcumin sensitizes prostate cancer cells to
tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear
factor-kappaB through suppression of IkappaBalpha phosphorylation. Molecular
Cancer Therapy. 2004;3(7):803-812.
- Deeb D, Xu YX, Jiang H, Gao X, Janakiraman N, Chapman RA, Gautam SC. Curcumin
(diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing
ligand-induced apoptosis in LNCaP prostate cancer cells. Molecular Cancer Therapy.
2003;2(1):95-103.
- Dorai T, Cao YC, Dorai B, Buttyan R, Katz AE. Therapeutic potential of curcumin
in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis,
and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate. 2001;47(4):293-303.
- Dorai T, Gehani N, Katz A. Therapeutic potential of curcumin in human prostate
cancer-I. curcumin induces apoptosis in both androgen-dependent and androgen-independent
prostate cancer cells. Prostate Cancer and Prostatic Diseases. 2000;3(2):84-93.
- Dorai T, Gehani N, Katz A. Therapeutic potential of curcumin in human prostate
cancer. II. Curcumin inhibits tyrosine kinase activity of epidermal growth factor
receptor and depletes the protein. Molecular Urology. 2000;4(1):1-6.
9. Cheng JH, Chang G, Wu WY. A controlled
clinical study between hepatic arterial infusion with embolized curcuma aromatic
oil and chemical drugs in treating
primary liver cancer. [Article in Chinese] Zhongguo Zhong Xi Yi Jie He Za Zhi.
2001;21(3):165-167.
- Thapliyal R, Naresh KN, Rao KV, Maru GB. Inhibition of nitrosodiethylamine-induced
hepatocarcinogenesis by dietary turmeric in rats. Toxicology Letter. 2003;139(1):45-54.
10. Deshpande UR, Gadre SG, Raste AS,
Pillai D, Bhide SV, Samuel AM. Protective effect of turmeric (Curcuma longa
L.) extract on carbon tetrachloride-induced liver damage in rats. Indian Journal
of Experimental Biology. 1998;36(6):573-577.
11 Collett
GP, Campbell FC. Curcumin induces c-jun N-terminal kinase-dependent apoptosis
in HCT116 human colon cancer
cells. Carcinogenesis. 2004 25(11):2183-2189.
- Ji M, Choi J, Lee J, Lee Y. Induction of apoptosis by ar-turmerone on various
cell lines. International Journal of Molecular Medicine. 2004;14(2):253-256.
- Baatout S, Derradji H, Jacquet P, Ooms D, Michaux A, Mergeay M. Effect of curcuma
on radiation-induced apoptosis in human cancer cells. International Journal of
Oncology. 2004;24(2):321-329.
- Chauhan DP. Chemotherapeutic potential of curcumin for colorectal cancer. Current
Pharmaceutical Design. 2002;8(19):1695-1706.
12 Tourkina E, Gooz P, Oates JC, Ludwicka-Bradley
A, Silver RM, Hoffman S. Curcumin-induced apoptosis in scleroderma lung fibroblasts:
role of protein kinase cepsilon. American Journal of Respiratory Cell and Molecular
Biology. 2004;31(1):28-35.
13 Hidaka H, Ishiko T, Furuhashi T,
Kamohara H, Suzuki S, Miyazaki M, Ikeda O, Mita S, Setoguchi T, Ogawa M. Curcumin
inhibits interleukin 8 production and enhances interleukin 8 receptor expression
on the cell surface: impact on human pancreatic carcinoma cell growth by autocrine
regulation. Cancer.
2002 Sep 15;95(6):1206-14.
14.
Huang MT, Newmark HL, Frenkel
K. Inhibitory effects of curcumin on tumorigenesis in mice. Journal of Cellular
Biochemistry Supplement. 1997;27:26-34.
- Leu TH, Maa MC. The molecular mechanisms for the antitumorigenic effect of
curcumin. Current Medical and Chemical Anti-Cancer Agents. 2002;2(3):357-370.
15 Arbiser JL, Klauber N, Rohan
R, van Leeuwen R, Huang MT, Fisher C, Flynn E, Byers HR. Curcumin is an in
vivo
inhibitor of angiogenesis. Molecular Medicine.
1998;4(6):376-383.
- Gururaj AE, Belakavadi M, Venkatesh DA, Marme D, Salimath BP. Molecular mechanisms
of anti-angiogenic effect of curcumin. Biochemistry and Biophysics Research Communications.
2002;297(4):934-942.
16. Ramachandran C, Fonseca HB, Jhabvala
P, Melnick SJ, Escalon E. Inhibition of human telomerase reverse transcritpase
(hhert) and telomerase activity by
curcumin in human mammary epithelial and breast carcinoma cell lines. Scientific
World Journal. 2001;1(1 Suppl 3):109.
17. Tumeric, the new active cosmetic
ingredient - about the project funded by the Government of Thailand to extract
THC from turmeric for cosmetics formulations
18. Villasenor IM, Simon MK, Villanueva
AM. Comparative potencies of nutraceuticals in chemically induced skin tumor
prevention. Nutrition and Cancer. 2002;44(1):66-70.
19. Mohanty I, Singh Arya D, Dinda
A, Joshi S, Talwar KK, Gupta SK. Protective effects of Curcuma longa on ischemia-reperfusion
induced myocardial injuries and
their mechanisms. Life Sciences. 2004;75(14):1701-1711.
20 Ramirez-Tortosa MC, Mesa MD,
Aguilera MC, et al. Oral administration of a turmeric extract inhibits LDL
oxidation
and has hypocholesterolemic effects in rabbits with experimental atherosclerosis.
Atherosclerosis 1999;147:371-378.
- Deters M, Klabunde T, Meyer H, Resch K, Kaever V. Effects of curcumin on cyclosporine-induced
cholestasis and hypercholesterolemia and on cyclosporine metabolism in the rat.
Planta Medica. 2003;69(4):337-343.
21. Reddy AC, et al. Effect of Dietary
Turmeric (Curcuma longa) on Iron-induced Lipid Peroxidation in the Rat Liver.
Food Chem Toxicol. Mar1994;32(3):279-83.
22 Ramprasad
C, Sirsi M. Curcuma longa and bile secretion. Quantitative changes in the bile
constituents induced by sodium curcuminate. J Sci Indust Res 1957;16C:108-110.
23 Daniel S, Limson JL, Dairam
A, Watkins GM, Daya S. Through metal binding, curcumin protects against
lead-
and cadmium-induced lipid peroxidation in rat
brain homogenates and against lead-induced tissue damage in rat brain. Journal
of Inorganic Biochemistry. 2004;98(2):266-275.
24 Calabrese V, Butterfield DA,
Stella AM. Nutritional antioxidants and the heme oxygenase pathway of stress
tolerance: novel targets for neuroprotection
in Alzheimer's disease. Italian Journal of Biochemistry. 2003;52(4):177-181.
- Baum L, Ng A. Curcumin interaction with copper and iron suggests one possible
mechanism of action in Alzheimer's disease animal models. Journal of Alzheimers
Disease. 2004;6(4):367-377.
25 Mahady
GB, Pendland SL, Yun G, Lu ZZ. Turmeric (Curcuma longa) and curcumin inhibit
the growth of Helicobacter
pylori, a group 1 carcinogen. Anticancer Research. 2002;22(6C):4179-4181.
- Foryst-Ludwig A, Neumann M, Schneider-Brachert W, Naumann M. Curcumin blocks
NF-kappaB and the motogenic response in Helicobacter pylori-infected epithelial
cells. Biochemistry and Biophysics Research Communications. 2004;316(4):1065-1072.
26 Salh B, Assi K, Templeman V, Parhar
K, Owen D, Gomez-Munoz A, Jacobson K. Curcumin attenuates DNB-induced murine
colitis. American Journal of Physiology and Gastrointestinal and Liver Physiology.
2003;285(1):G235-G243.
27 Itthipanichpong C, Ruangrungsi
N, Kemsri W, Sawasdipanich A. Antispasmodic effects of curcuminoids on isolated
guinea-pig ileum and rat uterus. Journal
of the Medical Association of Thailand. 2003;86 (Suppl 2):S299-S309.
28 Ukil
A, Maity S, Karmakar S, Datta N, Vedasiromoni JR, Das PK. Curcumin,
the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene
sulphonic acid-induced colitisb British Journal of Pharmacology. 2003;139(2):209-218.
29 Shah
BH, Nawaz Z, Pertani SA, Roomi A, Mahmood H, Saeed SA, Gilani AH. Inhibitory
effect of curcumin, a food spice from turmeric, on platelet-activating factor-
and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane
formation and Ca2+ signaling. Biochemistry and Pharmacology. 1999;58(7):1167-1172.
- Mao C, Xie H, Lu T. Studies on antiplatelet aggregation and anticoagulant action
of Curcuma phaeocaulis. [Article in Chinese] Zhong Yao Cai. 2000;23(4):212-213.
30 Arun N, Nalini N. Efficacy of turmeric
on blood sugar and polyol pathway in diabetic albino rats. Plant Foods in Human
Nutrition. 2002;57(1):41-52.
- Babu PS, Srinivasan K. Hypolipidemic action of curcumin, the active principle
of turmeric (Curcuma longa) in streptozotocin induced diabetic rats. Molecular
and Cellular Biochemistry. 1997;166(1-2):169-175.
- Suresh Babu P, Srinivasan K. Amelioration of renal lesions associated with
diabetes by dietary curcumin in streptozotocin diabetic rats. Molecular and Cellular
Biochemistry. 1998;181(1-2):87-96.
31 Apisariyakul A, Vanittanakom
N, Buddhasukh D. Antifungal activity of turmeric oil extracted from Curcuma
longa (Zingiberaceae). Journal of Ethnopharmacology. 1995;49(3):163-169.
- Jayaprakasha GK, Negi PS, Anandharamakrishnan C, Sakariah KK. Chemical composition
of turmeric oil--a byproduct from turmeric oleoresin industry and its inhibitory
activity against different fungi. Zeitschrift Fuer Naturforschung. Section C.
Biosciences. 2001;56(1-2):40-44.
- Negi PS, Jayaprakasha GK, Jagan Mohan Rao L, Sakariah KK. Antibacterial activity
of turmeric oil: a byproduct from curcumin manufacture. Journal of Agricultural
and Food Chemistry. 1999;47(10):4297-4300.
32 Jagetia GC, Rajanikant GK.
Role of curcumin, a naturally occurring phenolic compound of turmeric in
accelerating
the repair of excision wound, in mice
whole-body exposed to various doses of gamma-radiation. Journal of Surgical
Research. 2004;120(1):127-138.
- Jagetia GC, Rajanikant GK. Effect of curcumin on radiation-impaired healing
of excisional wounds in mice. Journal of Wound
Care. 2004;13(3):107-109.
33. Ashok P, Meenakshi B. Contraceptive
effect of Curcuma longa (L.) in male albino rat. Asian Journal of Andrology.
2004;6(1):71-74.
34 Shoskes DA. Effect of bioflavonoids
quercetin and curcumin on ischemic renal injury: a new class of renoprotective
agents. Transplantation. 1998;66(2):147-152.
|