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N-Acetilcisteina inbunatateste respiratia este un mucolitic cu efect bronhodilatator indicat la bronsitele acute si cronice, studiu randomizat, dublu-orb, placebo controlat.
Tromboza venoasa
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19
N-Acetilcisteina
in managementul de boli coronariene
20 N-Acetilcisteina cu parametri antioxidante la pacienti tratati de citostatica
la cancer
Miracolul antioxidant |
Terapia
Anti-Aging cu antioxidanti
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21 Teoria
radicalilor liberi in procesul de imbatrinire
Procesul de imbatranire cu cauzele endogene si exogene
- Radicalii liberi considerati ca mediatori patologici.
- Formarea de radicali liberi prin: Factorii exogeni ca poluarea aerului, razele-UV, radiatii ionizante, etc., factorii endogeni pot fi stres, exercitiu fizic extenuant, inflamatii, fumat, etc.
- Tipuri de radicali liberi: Radicalii liberi ai oxigenului, Radicalii liberi ai azotului, Radicalul thiil,etc
| Formarea de radicali liberi | Structura celulei este oxidata de actiunea agresiva a radicalilor liberi |
 |
 |
- Inalta concentratie de oxigen reactiv - radicalii liberi si cantitatea insuficienta in organism de antioxidanti, genera in organite (centrale energetice celulare) eficacitatea scazuta a repararii ADN-ului, ca rezultat: Disfunctia mitocondriala, care este o caracteristica a celulelor maligne.
22 N-Acetilcisteina un agent citostatic
la cancer cauza fiind stresul oxidativ si degradarea ADN
| Radicalii liberi produc stres oxidativ | Distrugerile ADN-ului de radicalii liberi care produc stres oxidativ |
 |
 |
- Mutatiile ADN-ului de radicalii liberi afecteaza energia celulara ATP Administrarea de antioxidanti ca factor anti cancer determina reversia fenotipului malign prin inhibarea celulelor de cancer - Anti cancer: EGCG Galatul de epigalocatechina
| Degradarea ADN-ului prin acumularea de 8-hidroxi-2’-deoxiguanozina | Reversia fenotipului malign prin inhibarea celulelor de cancer |
 |
 |
Neutralizarea de radicali liberi - Densitatea antioxidativa
Despre antioxidanti: Antioxidantii
sint molecule care apara organismul de efectele oxigenului reactiv -
Radicalii liberi
Radicalii liberi produc stres oxidativ, iar antioxidantii apara celula
de radicalii liberi care sint molecule instabile, contin electroni neimperecheati,
adica un electron ocupa un singur orbital.
23 N-Acetilcisteina
cu actiune antioxidanta de neutralizare de radicali liberi: radicalul superoxid (O2-), radicalul peroxil (RO2-), radicalul peroxinitrit (OONO -), peroxid de hidrogen (H2O2) previne oxidarea LDL - biologia si medicina radicalilor liberi
N-Acetilcisteina cu grupa tiol-sulfhidril (-SH) este precursor la L-Cisteina si Glutation redus (GSH) un antioxidant puternic
Disfunctia mitocondriala care este o caracteristica a celulelor maligne, datorat prin capacitatea scazuta antioxidativa.
| Antioxidantii apara celula de efectele oxigenului reactiv | Antioxidantii cu neutralizarea de radicali liberi - Capacitate scazuta antioxidativa |
 |
 |
- Antioxidanti se gasesc in orice
celula, protejeaza organismul de distrugerile provocate la nivel celular
de radicalii liberi.
- Antioxidantii pot neutraliza radicalii liberi limitind distrugerea provocata,
daca suficienti antioxidanti sint involvati - Capacitate suficienta antioxidativa
- Acid Alfa Lipoic prin proprietati si functie regenereaza alti antioxidanti
ca: Vitamina C, Vitamina E, Glutation, Coenzima Q10 ofera protectie antioxidativa
de efectele radicalilor liberi.
Antioxidantii protejind celula de radicalii liberi - Capacitate suficienta
Sint o multime de antioxidanti in extracte de plante naturale, fitofarmaceutice, nutraceutice cu capacite de neutralizare a radicalilor liberi Antioxidanti cheie: Acid Alfa Lipoic, Coenzima Q10, Vitamine: Vitamina C, Vitamina E, Caretenoizi, (beta caroten,alfa caroten, licopen, luteina, zeaxantina) Compusi fenolici: Flavonoizi, polifenoli care confera protectie ridicata antoxidativa
- Suficienti antioxidanti de recomandat: Acid Alfa Lipoic, Ceai Verde EGCG, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H 2O2) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari
Spirulina contine
superoxid dismutaza (SOD) un antioxidant puternic 110000 Unitati/100g
Suficienti antioxidanti de recomandat: Acid alfa lipoic, Ceai Verde, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H2O2) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari
| N_Acetilcisteina cu capacitate de absorbtie a radicalului liber a oxigenului - ORAC, comparatia valorilor fata de Vitamina C |
 |
24 Caracterizare
intre: N-Acetilcisteina si Ambroxol in terapia antioxidanta
25 N-Acetilcisteina
intareste sistemul imunitar
26 N-Acetilcisteina inhiba replicarea virusul de imunodeficienta-HIV
27 N-Acetilcisteina
cu efect anticancer
28 N-Acetilcisteina
cu Vitamina A in tratamentul de cancer de plamin, cancer cerebral, cancer la
git, studiu randomizat, dublu-orb, placebo
controlat
| N-Acetilcisteina in cura cu suplimente nutritive produse-naturale din medicina traditionala | |
 |
 |
29 N-Acetilcisteina
prin gruparea SH cu efect la terapia de chelatizare prin metilarea
de metale grele
ca mercur, si efectele toxice de la paracetamol
30 N-Acetilcisteina
in tratamentul de intoxicatie si reactii adverse ale medicamentelor
31 N-Acetilcisteina
in efectele toxice de la paracetamol - acetaminofen
32 N- Acetilcisteina un hepato protector
in dauna oxidativa hepatica indusa de isoniazid si rifampicin un antibiotic
bactericid prescris la tuberculoza
33 N-Acetilcisteina
ca antidot in intoxicatia cu Amanita phalloides
| Bibliografie-Referinte: |
 |
| Informatii din bibliografia electronica la tema: Nutritie si sanatate |
1 Long-term oral acetylcysteine
in chronic bronchitis: Adouble-blind controlled study.Multicenter Study GroupEur.
J. Respir. Dis.
61(Sup.):93 (1980)
2 Molnar
Z, Schearer E, Lowe D. N-acetylcysteine treatment to prevent the progression
of multisystem organ failure: a prospective,
randomized placebo-controlled
study. Crit Care Med. 1999; 27:1100-1104.
3 Randomised,
controlled trial of N-acetylcysteine for treatment of acute exacerbations of
chronic obstructive pulmonary disease Peter N Black , Althea Morgan-Day ,
Tracey E McMillan , Phillippa J Poole and Robert P Young Department of Medicine,
University of Auckland, Private Bag 92019, Auckland, New Zealand BMC Pulmonary
Medicine 2004, 4:13
4 Pela
R, Calcagni AM, Subiaco S, et al. N-acetylcysteine reduces the exacerbation
rate in patients with moderate
to severe
COPD. Respiration. 1999; 66:495-500.
5 Ortolani
O, Conti A, De Gaudio AR, et al. Protective effects of N-acetylcysteine and
rutin on the lipid peroxidation
of the lung epithelium during the adult
respiratory distress syndrome. Shock. 2000; 13:14-18.
- Sala R, Moriggi E, Corvasce G, Morelli D. Protection by N-acetylcysteine against
pulmonary endothelial cell damage induced by oxidant damage. Eur Respir J. 1993;
6:440-446.
6 Spies C, Reinhart K, Witt I, Meier-Hellmann
A, Hannemann L, Donald L, Bredle PD, Schaffartzik W: Influence
of N-acetylcysteine on indirect indicators of tissue oxygenation in septic
shock patients: results from a prospective, randomized,
double-blind study. Crit Care Med 1994, 22:1738-1746.
7 Rank
N, Michel C, Haertel C, Lenhart A, Welte M, Meier-Hellmann A, Spies C: N-acetylcysteine
increases liver blood flow and improves liver function in septic shock patients:
results of a prospective, randomized, double-blind study. Crit Care Med
2000, 28:3799-3807.
- Zhang H, Spapen H, Nguyen DN, Rogiers P, Bakker J, Vincent JL: Effects of
N-acetyl-L-cysteine on regional blood flow during endotoxic shock. Eur Surg
Res 1995, 27:292-300.
- Ott P: Effects of N-acetylcysteine on hepatic blood flow and function [letter].
Crit Care Med 1998, 26:415.
8 Harrison
PM, Wendon JA, Gimson AES, et al. Improvement by acetylcysteine of hemodynamics
and oxygen transport in fulminant hepatic failure. N Engl
J Med.
1991; 324:1852-1857.
- Devlin J, Ellis AE, McPeake J, Heaton N, Wendon JA, Williams R: N-acetylcysteine
improves indocyanine green extraction and oxygen transport during hepatic dysfunction.
Crit Care Med 1997, 26:236-242
9 Acetylcysteine: A drug that is much
more than a mucokinetic.Ziment, I.Biomed.
Pharmacother. 42:513-20 (1988)
- The reduction in vitro in viscosity of mucoproteinsolutions by a new mucolytic
agent, N-acetylcysteine.Sheffner, A. L.Ann. NY Acad. Sci. 106:288 (1963)
- Holdiness MR. Clinical pharmacokinetics of N-acetylcysteine. Clinical Pharmacokinet.
1991; 20:123-134.
- Clinical pharmacokinetics of N-acetylcysteine.Borgstrom, L., Kagedal, B.
and Paulsen, O.Eur. J. Clin. Pharmacol. 31:217-22 (1986)
- Pharmokinetics and bioavailability of reduced and oxidizedN-acetylcysteine.Olsson,
B., et al,Eur. J. Clin. Pharmocol. 34:77-82 (1988)
- Pharmacokinetics and bioavailability of oral acetylcysteinein healthy volunteers.De
Caro, L., et al,Arzneim.-Forsch/Drug Res., 39:382 (1989)
- Clinical pharmacokinetics of N-acetylcysteine.Holdiness, M. R.Clin. Pharmacokinet.
20:123-34 (1991)
10 Jones AL, Jarvie DR, Simpson D,
et al. Pharmacokinetics
of N-acetylcysteine are altered in patients with chronic liver disease.
Aliment Pharmacol Ther. 1997; 11:787-791.
11 Louwerse ES, Weverling GJ, Bossuyt
PM, et al. Randomized double-blind controlled trial of acetylcysteine in
amyotrophic lateral sclerosis. Arch Neurol. 1995;
52:559-564.
12 Martinez M, Hernandez AI, Martinez
N. N-acetylcysteine
delays age-associated memory impairment in mice: role in synaptic mitochondric.
Brain Res. 2000; 855:100-106.
13 Lipoprotein(a) reduction by N-acetylcysteine.Hansen,
P. R.Lancet 337:672-3
(1991)
- Gavish D, Breslow JL. Lipoprotein (a) reduction by N-acetylcysteine. Lancet.
1991; 337:203-204.
- Lp(a) lipoprotein as a risk factor for myocardialinfarction.Rhoads, G. G.,
et al,JAMA 256:2540-4 (1986)
14 Beneficial effects of N-acetylcysteine
and cysteine instunned myocardium in perfused rat heart.Tang, L-D., et al,Brit.
J. Pharmacol. 102(3):601-6 (1991)
15 Ceconi C, Curello S, Cargnoni A, Ferrari R, Albertini A, Visioli O. The
role of glutathione status in the protection against ischaemic and reperfusion
damage: effects of N-acetyl cysteine. University of Brescia, Chair of Cardiology,
Italy. J Mol Cell Cardiol. 1988 Jan;20(1):5-13.
16 Ardissino D, Melini PA,
Savonitto S, et al. Effect of transdermal nitroglycerin or N-acetylcysteine,
or both, in the long-term treatment of unstable angina
pectoris. J Am Coll Cardiol. 1997; 29:941-947.
- Horowitz JD, Henry CA, Syrjanen ML, et al. Nitroglycerine/N-acetylcysteine
in the management of unstable angina pectoris. Eur Heart J. 1988; 9 Suppl A:95-100.
- Hogan JC, Lewis MJ, Henderson AH. Chronic administration of N-acetylcysteine
fails to prevent nitrate tolerance in patients with stable angina pectoris.
Br J Clin Pharmacol. 1990; 30:573-577.
- Unverferth DV, Jagadeesh JM, Unverferth BJ, et al. Attempt to prevent doxorubicin-induced
acute human myocardial morphologic damage with acetylcysteine. J Natl Canc Inst.
1983; 71:917-920.
17 Ghio S, de Servi S, Perotti R,
et al. Different susceptibility to the development of nitroglycerin tolerance
in
the arterial and venous circulation in humans-
effects of N-acetylcysteine administration. Circulation 1992;86:798-802.
18 Jepsen S, Hansen AB. The
influence of N-acetylcysteine on the measurement of prothrombin time and activated
partial thromboplastin time in healthy subjects. Scand J Clin Lab Invest
1994;54:543-7.
19 Marchetti G, Lodola E, Licciardello
L, Colombo A. Use of N-acetylcysteine in the management of coronary artery
diseases. Cardiologia. 1999; 44:633-637.
20 Bongers V, de Jong J, Steen I,
et al. Antioxidant-related parameters in patients treated for cancer chemoprevention
with N-acetylcysteine. Europ J Cancer. 1995;
31A:921-923.
21 Beckman, K. & Ames, B. (1998) "The
free radical theory of aging matures" Physiol Rev 78: 548-81.
22 Oikawa S, Yamada K, Yamashita N, et al. N-acetylcysteine,
a cancer chemopreventive agent, causes oxidative damage to cellular and isolated
DNA. Carcinogenesis.
1999; 20:1485-1490.
23 Aruoma OI, Halliwell B, Hoey
BM, Butler B: The antioxidant action of N-acetylcysteine; its reaction
with hydrogen
peroxide, hydroxyl radical, superoxide, and hypochlorous
acid. J Free Radic Biol Med 1989, 6:593-597.
24 Gillissen A, Nowak D. Characterization
of N-acetylcysteine and ambroxol in
anti-oxidant therapy. Respir Med 1998;92:609-23.
25 De Flora S, Grassi C, Carati
L. Attenuation of influence-like symptomatology and improvement of cell-mediated
immunity with long-term N-acetylcysteine treatment.
Eur RespirJ. 1997; 10:1535-1541.
26 Roederer M, Staal FJT, Raju PA, et al. Cytoline-stimulated human immunodeficiency
virus replication is inhibited by N-acetyl-L-cysteine. Proc Natl Accd Sci. 1990;
87:4884-4888.
- Kelebic T, Kinter A, Poli G, et al. Suppression of human immunodeficiency virus
expression in chronically infected monocyte cells by glutathione, glutathione
ester, and N-acetylcysteine. Proc Natl Accd Sci. 1991; 88:986-990.
27 Metabolic, desmutagenic and
anticarcinogenic effects of N-acetylcysteine.De Flora, Silvio, Rossi, G.
A. and De Flora,
A.Respiration 30(suppl. 1):43-9 (1986)
- In vitro effects of N-acetylcysteine on the mutagenicity ofdirect-acting
compounds and procarcinogens.De Flora, Silvio, et al,Carcinogenesis 5(4):505-10
(1984)
- In vivo effects of N-acetylcysteine on glutathionemetabolism and on the
biotransformation of carcinogenicand/or mutagenic compounds.De Flora, Silvio,
et alCarcinogenesis
6(12):1735-45 (1985)
- Detoxification of genotoxic compounds as a thresholdmechanism limiting their
carcinogenicity.De Flora, S.Toxicol. Pathol. 12(4):337-43 (1984)
- Effects of N-acetyl-L-cysteine and ascorbic acid on mutagen-induced chromosomal
sensitivity in patients with head and neck cancers.Trazana, Zoltan, et al,Amer.
J. Surg. 162:294-8 (1991)
- Effect of exogenous glutathione on tumor progression in themurine skin multistage
carcinogenesis model.Rotstein, J. B. and Slaga, T. J.
- Second-line chemotherapy in small-cell lung cancer.Andersen, M., Kristjansen,
P. E. G. and Hansen, H. H.Cancer Treat. Rev. 17(4):427-36 (1990)
- N-acetylcysteine as chemoprotectant in cancer chemotherapy.Martinez, Esteban
and Domingo, PereLancet 338:249 (July 27, 1991)
28 van Zandwijk N, Dalesio O, Pastorino
U, et al. EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine
in patients with head and neck cancer or
lung cancer. For the European Organization for Research and Treatment
of Cancer Head and Neck and Lung Cancer Cooperative Groups. J Natl Cancer
Inst
2000;92:977-86.
- van Zandwijk N. N-acetylcysteine for lung cancer prevention. Chest 1995;107:1437-41.
29 Experimental chelation therapy
in
chromium, lead and boronintoxification with N-acetylcysteine.Tong, T. G.Toxicol.
Appl. Pharmacol. 83:142-7 (1986)
- Ballatori N, Lieberman MW, Wang W. 1998. N-acetylcysteine as an antidote
in
methylmercury poisoning. Environ Health Perspect. 106(5):267-71.
- Dawson AH, et al. Adverse reactions to N-acetylcysteine during treatment for
paracetamol poisoning. Med J Aust. 1989; 150:329-331.
- N-acetylcysteine therapy of acute heavy metal poisoning inmice.Henderson, P.,
et al,Vet. Hum. Toxicol. 27:522-5 (1985)
30 Chyka PA, Butler AY, Holliman
BJ, Herman MI. Utility of acetylcysteine in treating poisonings and adverse
drug reactions. Drug Saf 2000;22:123-48.
31 Mechanism of action of N-acetylcysteine
in the protectionagainst hepatotoxicity of acetaminophen in rats in vivo.Lauterburg,
B. H., Corcoran, G. B. and Mitchell,
J. R.J. Clin. Invest. 71:980-991 (1983)
- Hazai E, Monostory K, Bakos A, Zacher G, Vereczkey L. About
paracetamol again Magyar Tudományos Akadémia, Budapest,
Kémiai Kutatóközpont,
Farmakobiokémiai Osztály. Orv Hetil. 2001 Feb 18;142(7):345-9.
32 Attri S, Rana SV, Vaiphie K, Katyal
R, Sodhi CP, Kanwar S, Singh K. Protective
effect of N-acetylcysteine in isoniazid induced hepatic injury in growing rats.
Department of Biochemistry, Govt. Medical College, Chandigarh 160 032, India.
Indian J
Exp Biol. 2001 May;39(5):436-40.
- Attri S, Rana SV, Vaiphei K, Sodhi CP, Katyal R, Goel RC, Nain CK, Singh K.
Isoniazid-
and rifampicin-induced oxidative hepatic injury--protection by N-acetylcysteine.
Department of Gastroenterology, Postgraduate Institute of Medical Education and
Research,
Chandigarh, India. Hum Exp Toxicol. 2000 Sep;19(9):517-22.
33 Montanini S, Sinardi D, Pratico
C,
et al. Use of acetylcysteine as the life-saving antidote in Amanita phalloides
(death cap) poisoning. Case report on 11 patients. Arzneimittel-forschung. 1999;
49:1044-1047.
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