|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
- Inalta concentratie de oxigen reactiv - radicalii liberi si cantitatea insuficienta in organism de antioxidanti, genera in organite (centrale energetice celulare) eficacitatea scazuta a repararii ADN-ului, ca rezultat: Disfunctia mitocondriala, care este o caracteristica a celulelor maligne.8
- Mutatiile ADN-ului de radicalii liberi afecteaza energia celulara ATP Administrarea de antioxidanti ca factor anti cancer determina reversia fenotipului malign prin inhibarea celulelor de cancer - Anti cancer: EGCG Galatul de epigalocatechina
Neutralizarea de radicali liberi - Densitatea antioxidativa Despre antioxidanti: Antioxidantii
sint molecule care apara organismul de efectele oxigenului reactiv -
Radicalii liberi
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frunze de Maslin (Olea Europaea) cu efect terapeutic hipocolesterolemiant natural, scade nivelul crescut al colesterolului total cu 42%, important la Cura de Slabire, moduleaza metabolismul lipidic in obezitate si prediabet, studiu comparativ cu Zocor (Simvastatin), care scade nivelul crescut al colesterolului total doar cu 32%. 
| Antioxidantii apara celula de efectele oxigenului reactiv | Antioxidantii cu neutralizarea de radicali liberi - Capacitate scazuta antioxidativa |
 |
 |
- Antioxidanti se gasesc in orice
celula, protejeaza organismul de distrugerile provocate la nivel celular
de radicalii liberi.
- Antioxidantii pot neutraliza radicalii liberi limitind distrugerea provocata,
daca suficienti antioxidanti sint involvati - Capacitate suficienta antioxidativa
- Acid Alfa Lipoic prin proprietati si functie regenereaza alti antioxidanti
ca: Vitamina C, Vitamina E, Glutation, Coenzima Q10 ofera protectie antioxidativa
de efectele radicalilor liberi.
Antioxidantii protejind celula de radicalii liberi - Capacitate suficienta
Sint o multime de antioxidanti in extracte de plante naturale, fitofarmaceutice, nutraceutice cu capacite de neutralizare a radicalilor liberi Antioxidanti cheie: Acid Alfa Lipoic, Coenzima Q10, Vitamine: Vitamina C, Vitamina E, Caretenoizi, (beta caroten,alfa caroten, licopen, luteina, zeaxantina) Compusi fenolici: Flavonoizi, polifenoli care confera protectie ridicata antoxidativa
- Suficienti antioxidanti de recomandat: Acid Alfa Lipoic, Ceai Verde EGCG, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H 2O2) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari
Spirulina contine
superoxid dismutaza (SOD) un antioxidant puternic 110000 Unitati/100g
Suficienti antioxidanti de recomandat: Acid alfa lipoic, Ceai Verde, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H2O2) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari
Antioxidantii protejind celula de radicalii liberi - Capacitate suficienta
11
Dezvoltarea si validarea aprobarii denumirii ORAC - Capacitate de absorbtie a
radicalului liber a oxigenului de antioxidanti
Oleuropeina cu capacitate de absorbtie a radicalului liber a oxigenului - ORAC, comparatia valorilor fata de Vitamina C
12 Analiza farmacologica de Oleuropeina
un iridoid
13 Oleuropeina
din
Frunze de Maslin un imunomodulator confera prelungirea supravietuirii de bacilul
piocianic (Pseudomonas aeruginosa)
14 Oleuropeina
din Frunze de Maslin cu studii mecanismului
de actiune antimicrobiala
Frunze de Maslin un antibiotic natural contra infectiilor fungice, bacteriene si virale
15 Oleuropeina si
hidroxitirosol cu activitate antimicrobiala
16 Frunze de Maslin
(Olea Europaea) cu activitate antimicrobiala
17 Oleuropeina cu
efect de inhibare a cresteri de stafilococul auriu (Staphylococcus aureus)
18 Oleuropeina cu
efect de inhibare a Salmonella enteritidis
19 Oleuropeina cu
efect antibacteriala si antifungica: studiu comparativ la fenoli
20 Frunze de Maslin
(Olea Europaea) cu activitate antivirala la Viral Hemorrhagic Septicemia
Rhabdovirus ( VHSV)
21 Oleuropeina cu componentul activ
de Calciu Elenolate un agent antiviral
22 Calciu
Elenolate cu specific de agent antiviral
23 Calciu
Elenolate cu activitate antivirala
24 Calciu
Elenolate cu activitate antivirala la infectia parainfluenta
25 Calciu
Elenolate inactiveaza ADN polimeraza virala a virusului leucemiei murine
26 Calciu
Elenolate inactiveaza mixovirusuri
27 Frunze
de Maslin (Olea Europaea) cu activitate anti-HIV
28 Oleuropeina
cu efect hipoglicemic si antioxidanta
29 Frunze
de Maslin (Olea Europaea) cu efect hipoglicemic, hipotensiv si hipouricemia
- diminueaza nivelul de acid uric in sange la guta
30 Oleuropeina cu protectie de
oxidarea LDL
31 Studii farmacologice a plantelor
cu actiune de vasodilator si aritmica
32 Frunze de Maslin (Olea europaea)
cu efect vasodilator si antihipertensiv
33Frunze de Maslin (Olea Europaea)
in tratamentul hipertensiunii, studiu clinic
34Frunze de Maslin (Olea Europaea) reduce
tensiunea arteriala la hipertensiune
35 Oleuropeina creste productia
de oxid nitric (NO) - mentine vasele de sange si capilarele
flexible
36 Frunze de Maslin (Olea Europaea) un
inhibitor al enzimei de conversie a angiotensinei (ACE)
37 Frunze de Maslin (Olea Europaea)
cu efect la hipercolesrolemia si diabet
38
Dieta cu specific mediteraneana
are efect de reducerea lipidelor serice
| Dieta cu specific mediteraneana are efect de reducerea lipidelor serice |
 |
39 Frunze de Maslin (Olea Europaea)
cu activitate anti clastogenica, cu efect radioprotector de razele X care
induce dauna cromozomiala: studiu comparativ
| Bibliografie-Referinte: |
 |
| Informatii din bibliografia electronica la tema: Nutritie si sanatate |
1 Bennani-Kabchi N, Fdhil H, Cherrah
Y, El Bouayadi F, Kehel L, Marquie G. Therapeutic
effect of Olea europea var. oleaster leaves on carbohydrate and lipid metabolism
in obese and prediabetic sand rats (Psammomys obesus) UFR Nutrition Aliment
Santé, Faculté des Sciences, Université Mohamed V, Avenue
IBn Battouta, BP 1014 Rabat, Maroc. Ann Pharm Fr. 2000 Jul;58(4):271-7.
- Ribeiro, R., et al. Acute Anithypertensive Effect in Conscious Rats Produced
by Some Medicinal Plants Used in the State of Sao Paolo. Journal of Ethnopharmacology
15(3): 261-9, March 1986
2 Mossa,
J.S. Experimental Evaluation of Some Saudi Plants for their Antidiabetic Activity.
IRCS Med. Sci. 14: 13-14,
1986.
- Gonzalez, M., A. Zarzuelo, M. J. Gamez, M. P. Utrilla, J. Jimenez and
I. Osuna (1992). "Hypoglycemic activity of olive leaf." Planta Med
58(6): 513-5.
3 Le Tutour, D. Guedon, 1992. Antioxidant
activities of Olea europaea leaves and related phenolic compounds, Phytochemistry.
vol. 31, pp. 1173 - 1178.
4 O. Benavente-Garcia, J. Castillo,
J. Lorente, A. Ortyno, J.A. Del Rio 2000.
Antioxidant
activity of phenolics extracted from Olea europaea L. leaves, Food Chem.
Vol. 68, pp. 457-462.
5 Andreadou I, Iliodromitis EK, Mikros
E, Constantinou M, Agalias A, Magiatis P, Skaltsounis AL, Kamber E, Tsantili-Kakoulidou
A, Kremastinos DT. The
olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic
effects in anesthetized rabbits. Second University Department of Cardiology,
Medical School, Attikon General Hospital, University of Athens, Athens, Greece.
J Nutr. 2006 Aug;136(8):2213-9.
- Edgecombe SC, Stretch GL, Hayball PJ. Oleuropein,
an antioxidant polyphenol from olive oil, is poorly absorbed from isolated perfused
rat intestine. Centre for Pharmaceutical Research, University of South Australia,
North Terrace, Adelaide, South Australia, 5000, Australia.
J Nutr. 2000 Dec;130(12):2996-3002.
6 Cao
G, Alessio HM, Cutler RG. Oxygen-radical absorbance capacity assay for antioxidants.
Gerontology Research Center,
National Institute on Aging, NIH, Baltimore, MD 21224. Free Radic Biol Med. 1993
Mar;14(3):303-11.
7 Beckman, K. & Ames, B. (1998) "The free radical theory of aging matures" Physiol Rev 78: 548-81.
8 Akiba S, Kawauchi T, Oka T, Hashizume T, Sato T.Inhibitory effect of the
leaf extract of
Ginkgo biloba L. on oxidative stress-induced platelet aggregation.Department
of Pathological Biochemistry, Kyoto Pharmaceutical University, Japan.Biochem
Mol Biol Int. 1998
Dec;46(6):1243-8.
9 Haramaki N, Aggarwal S, Kawabata T, Droy-Lefaix MT, Packer L.Effects
of natural antioxidant ginkgo biloba extract (EGB 761) on myocardial ischemia-reperfusion
injury. Department of Molecular and Cell Biology, University of California, Berkeley
94720.Free Radic Biol Med. 1994 Jun;16(6):789-94.
10 Bekerecioglu M, Tercan M, Ozyazgan I.The effect of Gingko
biloba extract (Egb 761) as a free radical scavenger on the survival of skin
flaps in rats. A comparative study. Department of Plastic and Reconstructive
Surgery, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.Scand J Plast
Reconstr Surg Hand Surg.
1998 Jun;32(2):135-9.
11 Ou B, Hampsch-Woodill M, Prior RL. Development
and validation of an improved oxygen radical absorbance capacity assay using
fluorescein as the fluorescent probe. Brunswick Laboratories, 6 Thacher
Lane, Wareham, Massachusetts 02571, USA. J Agric Food Chem. 2001 Oct;49(10):4619-26.
12 Petkov
V, Manolov P. Pharmacological analysis of the iridoid oleuropein. Arzneim
Forsch/Drug Research 1972;22:1476–86.
13 EJ Giamarellos-Bourboulis, T Geladopoulos,
M Chrisofos, P Koutoukas, J Vassiliadis, I Alexandrou, T Tsaganos, L Sabracos,
V Karagianni, E Pelekanou,
I Tzepi, H Kranidioti, V Koussoulas, H Giamarellou Oleuropein
: A novel immunomodulator conferring prolonged survival in experimental
sepsis by Pseudomonas aeruginosa Fourth Department of Internal Medicine,
Medical School, University of Athens; AlterChem Co; and Second Department
of Urology, University of Athens, Medical School, Athens, Greece. 2006,
vol. 26, no4, pp. 410-416 [7 page(s) (article)]
(15 ref.)
14 Juven B, Henis Y, Jacoby B. Studies
on the mechanism of the antimicrobial
action of oleuropein. J Appl Bacteriol. 1972 Dec;35(4):559-67.
15 Bisignano G, Tomaino A, Lo Cascio
R, Crisafi G, Uccella N, Saija A. On
the
in-vitro antimicrobial activity of oleuropein and hydroxytyrosol. Department
Farmaco-Biologico,
University of Messina, Italy. J Pharm Pharmacol. 1999 Aug;51(8):971-4.
16 Markin D, Duek L, Berdicevsky I. In
vitro antimicrobial activity of olive
leaves. Department of Microbiology, Rappaport Faculty of Medicine, Technion-Institute
of Technology, Haifa, Israel. Mycoses. 2003 Apr;46(3-4):132-6.
- Walker, M. Antimicrobial Attributes of Olive Leaf Extract. Townsend Letter
for Doctors & Patients,
July 1996.
17 Tranter HS, Tassou SC, Nychas GJ. The
effect of the olive phenolic compound, oleuropein, on growth and enterotoxin
B production by Staphylococcus aureus. Division of Biologics, PHLS Centre
for Applied Microbiology and Research, Salisbury, Wilts, UK. J Appl Bacteriol.
1993 Mar;74(3):253-9.
18 Tassou CC, Nychas GJ. Inhibition
of Salmonella enteritidis by oleuropein in broth and in a model food system.
National Agricultural Research Foundation, Institute of Technology of Agricultural
Products, Lycovrysi, Athens, Greece. Lett Appl Microbiol. 1995 Feb;20(2):120-4.
19 Aziz NH, Farag SE, Mousa LA, Abo-Zaid
MA. Comparative
antibacterial and antifungal
effects of some phenolic compounds. National Centre for Radiation Research
and
Technology, Nasr City, Cairo, Egypt. Microbios. 1998;93(374):43-54.
20 Micol
V, Caturla N, Pérez-Fons
L, Más V, Pérez L, Estepa A. The
olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia
rhabdovirus (VHSV). Instituto de Biología Molecular y Celular, Universidad
Miguel Hernández, E-03202-Elche, Alicante, Spain. Antiviral Res. 2005
Jun;66(2-3):129-36. Epub
2005 Apr 18.
21 Elliott GA, Buthala DA, DeYoung
EN. Preliminary
safety studies with calcium elenolate,
an antiviral agent. Antimicrobial Agents Chemother (Bethesda). 1969;9:173-6.
22 Heinze JE, Hale AH, Carl PL. Specificity
of the antiviral agent calcium elenolate.Antimicrob Agents Chemother. 1975
Oct;8(4):421-5.
23 Renis HE. In
vitro antiviral activity of calcium elenolate. Antimicrobial Agents Chemother
(Bethesda). 1969;9:167-72.
24 Soret MG. Antiviral
activity of calcium elenolate on parainfluenza infection of hamsters. Antimicrobial
Agents Chemother (Bethesda). 1969;9:160-6.
25 Hirschman SZ. Inactivation
of DNA polymerases of murine leukaemia viruses by calcium elenolate. Nat
New Biol. 1972 Aug 30;238(87):277-9.
26Renis HE. Inactivation
of myxoviruses by calcium elenolate. Antimicrob Agents Chemother. 1975
Aug;8(2):194-9.
27 Lee-Huang
S, Zhang L, Huang PL, Chang YT, Huang PL. Anti-HIV
activity of olive leaf extract (OLE) and modulation of host cell gene expression
by HIV-1 infection and OLE treatment. Department of Biochemistry, New York
University School of Medicine, New York, NY 10016, USA. Biochem Biophys Res
Commun. 2003 Aug 8;307(4):1029-37.
28 Al-Azzawie HF, Alhamdani MS. Hypoglycemic
and antioxidant effect of oleuropein
in alloxan-diabetic rabbits. Biochemistry Department, College of Science,
University of Baghdad, Baghdad, Iraq. Life Sci. 2006 Feb 16;78(12):1371-7. Epub
2005 Oct
19.
29 Fehri
B, Aiache JM, Memmi A, Korbi S, Yacoubi MT, Mrad S, Lamaison JL. Hypotension,
hypoglycemia and hypouricemia recorded after repeated administration of aqueous
leaf extract of Olea europaea L. Département
de Pharmacologie et de
Toxicologie,
Société des Industries Pharmaceutiques de Tunisie, Fondouk Choucha,
Radès. J Pharm
Belg. 1994 Mar-Apr;49(2):101-8.
30 Visioli F, Galli C. Oleuropein
protects low density lipoprotein from oxidation. University of Milan, Institute
of Pharmacological Sciences, Italy. Life Sci. 1994;55(24):1965-71.
31 Petkov,
V. & Manolov, P. Pharmacological
Studies on Substances of Plant Origin with Coronary Dilating and Antiarrhythmic
Action. Comparative Medicine
East & West, Vol. VI, No. 2, 123-130.
32 Mossa, J.S. Experimental Evaluation
of Some Saudi Plants for their Antidiabetic Activity. IRCS Med. Sci. 14: 13-14,
1986.
- Gonzalez, M., A. Zarzuelo, M. J. Gamez, M. P. Utrilla, J. Jimenez and I. Osuna
(1992). "Hypoglycemic activity of olive leaf." Planta
Med 58(6): 513-5.
- Zarzuelo A, Duarte J, Jimenez J, Gonzalez M, Utrilla MP. Vasodilator
effect of olive leaf. Planta Med . 1991;57:417-9.
33 Cherif S, Rahal N, Haouala M,
et al. A clinical trial of a titrated Olea extract in the treatment of essential
arterial hypertension. J Pharm Belg
. 1996;51:69-71.
34 Khayyal MT, el-Ghazaly MA, Abdallah
DM, Nassar NN, Okpanyi SN, Kreuter MH. Blood
pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME
induced hypertension in rats. Department of Pharmacology, Faculty of
Pharmacy, Cairo University, Cairo, Egypt. Arzneimittelforschung. 2002;52(11):797-802.
35 Visioli F, Bellosta S, Galli
C. Oleuropein,
the bitter principle of olives, enhances nitric oxide production by mouse
macrophages. Institute of Pharmacological Sciences, Milan, Italy.
Francesco.Life Sci. 1998;62(6):541-6.
36 Hansen K, et al. Isolation
of an angiotensin converting enzyme (ACE) inhibitor from olea europaea
and olea lacea. Phytomedicine. 1996;2:319-325.
37 Bennani-Kabchi
N, Fdhil H, Cherrah Y, Kehel L, el Bouayadi F, Amarti A, Saïdi
M, Marquié G.
Effects of Olea europea var. oleaster leaves in hypercholesterolemic
insulin-resistant
sand rats. Département de Biologie, Faculté des Sciences,
Université Med V, Rabat, Maroc. Therapie. 1999 Nov-Dec;54(6):717-23.
38 Ferro-Luzzi A, Strazzullo
P, Scaccini C, Siani A, Sette S, Mariani MA, Mastranzo P, Dougherty
RM, Iacono JM, Mancini M. Changing
the Mediterranean diet: effects on blood lipids. Am J Clin Nutr.
1984 Nov;40(5):1027-37.
39 Benavente-Garcia
O, Castillo J, Lorente J, Alcaraz M. Radioprotective
Effects In Vivo of Phenolics Extracted from Olea europaea L. Leaves Against
X-Ray-Induced Chromosomal Damage: Comparative Study Versus Several Flavonoids
and Sulfur-Containing Compounds Research and Development Department,
Furfural Espanol S.A., Camino Viejo de Pliego s/n, 80320 Alcantarilla,
Murcia,
Spain. 2002, 5(3): 125-135. doi:10.1089/10966200260398152.
Parerea din pasajele acestui site nu a fost independent cercetate sau confirmate.
|
Anti-Aging-Systeme
© 2008
|
Design by NB |