Echilibru Hormonal Diindolylmethane
Echilibru Hormonal
cu Diindolylmethane
Totul despre Diindolylmethane, metabolismul estrogenului, promovarea reducerii
greutatii corporale, echilibru hormonal
Tratamente naturiste pentru cancer

Totul despre Diindolylmethane de Dr. Michael A.
Zeligs

Diindolylmethane pentru promovarea echilibrului hormonal, sindromul premenstrual
si preventia de cancer
Diindolylmethane cu echilibru homonal, anti-cancer, citostatic, anti-angiogeneza,
apoptoza, antiinflamator, anti-bacterial, anti-viral, anti-androgen

Biodisponibilitatea la Bioresponse DIM de 2,5 x mai mult DIM Diindolylmethane fata
de DIM Diindolylmethane normal (Generic)

1. Indole-3-Carbinol cu efect in metabolismul estrogenului prin cresterea de estrogen 2-hidroxilat,
inactiveaza estrogenii endogeni nefavorabili (17beta-estradiol) si
estron, reduce riscul de cancer mamar
2. Estrogen, Estrogen plus progestin cu risc de cancer mamar
3. Risc de cancer endometrial in relatia de folosinta de estrogeni combinat cu progestagen la femei in postmenopauza
4. Raspuns de cancer endometrial prin
folosinta de estrogeni combinat cu progestagen - Anticonceptionalul
- Contraceptivele
5. Celulele tumorale circulatoare (CTC) prezice supravietuire la pacientii cu
cancer de prostata metastazat.
Circulatia sangvina a celulelor canceroase

6. Celulele tumorale circulatoare (CTC) versus imaginile
obtinute in urma mamografiei prezice supravietuire la cancerul mamar
metastazat.
In testul sagvin pentru cancer se masoara
numarul de celule tumorale circulatoare (CTC) (the number of circulatory
tumor cells (CTC) in the bloodstream)
Test sangvin pentru cancer

Liber de dureri insuportabile: Terapia de substitutie
hormonala cu efectele adverse cancer mamar, ovarian, aratat in studiu
la un milion de femei

7. Cancer ovarian cauzat prin terapia de substitutie hormonala, studiu
la un milion de femei
Ce nu va relateaza medicul despre terapia de substitutie hormonala

Cum echilibrul hormonal poate ajuta salvarea vietii: Dr. John R Lee
8. Terapia de substitutie hormonala cu risc de boli
cardiovasculare la femei in menopauza
Echilibru hormonal cu produse-naturale in menopauza Dr. John R Lee

Ce nu va relateaza medicul despre menopauza: Dr. John R Lee
9. Indole-3-Carbinol induce
potent citocrome P450 continut masurat la enzimele microsomale hepatice,
P450 este dependent in metabolismul de estrogen.
10. Indole-3-Carbinol in
tratamentul acut si cronic la cancerului mamar indus de glanda mamara
prin oxidarea de (17 beta-estradiol) si estron - Estrogeni nefavorabili,
estradiolul poate fi metabolizat in 2 hidroxi estrogen (2OHE) si 2
metoxi estrogen sint estrogeni favorabili, iar estron in: 2 hidroxiestron
(2OHE1) si 2 metoxiestron (2MeOE1) estrogeni favorabili
- Estrogen 2 hidroxilaza convertesc estrogenul 2 hidroxi
estrogen (2OHE) si 2 metoxi estrogen care sint estrogeni favorabili
cu protectie, anti proliferativa
11. Hidrolizarea de 17 beta-estradiol prin catalizarea
de citocrome 450 1B1
12. Receptorul AH se leaga de Indole-3-Carbinol si Diindolylmethane care induce
hidroxilarea estradiolului, in procesul de hidroxilare estrogen 2 hidroxilaza
(EH), microzomala (citocrom P450) este involvat si receptorul AH
Diindolylmethane induce hidroxilarea estradiolului

13 Indole-3-Carbinol si
Diindolylmethane este un aril hidrocarbon receptor agonist (AH)
14 Diindolylmethane este un aril hidrocarbon receptor care mediaza ca anti-estrogen
si anti cancer
15 Diindolylmethane activeaza receptorul estrogenic (ER) la cancerul mamar
- 2 hidroxiestron (2OHE1) si 2 metoxiestron (2MeOE1)
estrogeni favorabili cu protectie pentru organism, anticarcinogenici
- Schimbarea nivelului de metabolitii de estrogen dupa
tratamentul cu de Indole-3-Carbinol
16. Estrogeni favorabili: 2 hidroxi estrogen (2OHE) si
2 metoxi estrogen sint estrogeni favorabili cu protectie anti proliferativa
17. 2 Metoxi estrogen un endogen estrogen metabolit care
inhiba carcinogeneza mamara
18 Presenta de Diindolylmethane dupa administrarea de Indole-3-Carbinol
- Glucosinolat este catalizat de enzima mirozinaza prin
hidroliza de conversie a glucobrassicinei din mediul acid al stomacului
in Indole-3-Carbinol.
- Indole-3-Carbinol este un precursor
de Diindolylmethane prin: Reactia de condensare DIM Diindolylmethane

19. Hidrolizarea de Glucosinolat in izotiocianati dupa
ingestia de Varza cruda
Hidrolizarea
de Glucosinolat in izotiocianati dupa ingestia de Varza cruda


20 Diindolylmethane cu efect citostatic la cancerul endometrial rezultat prin
medierea receptorului de estrogen
21 Farmacocinetica la Diindolylmethane dupa administrarea de Indole-3-carbinol
22 Diindolylmethane cu influenta la cresterea cancerului mamar si metastaza
23 Diindolylmethane induce apoptoza pe linia celulara MDA MB 231 la cancerul
mamar
24 Diindolylmethane are efect supresiv la cancerului mamar cu linia celulara
MCF-7
Echilibru
Hormonal: 103 mg, 30 Capsule 3,09 g
|
Analiza
Nutritiva: 2 Capsule contine: 206 mg - 30 Capsule 3,09 g
|
| BioResponse-DIM TM complex
(patentat extract standardizat 25% Diindolylmethane concentrat),
Diindolylmethane, Fosfatidilcolina, Soia |
100 mg
|
/**
|
| Protectamins ® concentrat
din Broccoli , Varza, Spanac - Sulfurofane 1% - Glucosinolat
2% |
100 mg
|
/**
|
| Vitamina E natural (d-alfa tocceferil
succinat) 9 IU |
6
mg
|
30%
|
25 Obezitatea, dieta, metabolismul de estrogen afectat: Dominanta estrogenica cu riscul de cancer hormonal
Indicat: Dieta anti-estrogenica, cura
de slabire cu Indole-3-Carbinol, Resveratrol sau Diindolylmethane

26 Diindolylmethane si Indole-3-Carbinol cu efect anti estrogenic, un citostatic natural
27. Broccoli inhiba carcinogeneza la vezica urinara

Diindolylmethane si Indole-3-Carbinol induce apoptoza la cancerul cervical numit
si cancerul de col uterin

30. Indole-3-Carbinol si Diindolylmethane induce apoptoza la cancerul de prostata

Indole-3-Carbinol, si
Diindolylmethane si sulforafan cu efect la cancerul de prostata:
dihidrotestosteronul (DHT) blocker

32. Diindolylmethane la adenomul
de prostata (hiperplazia benigna de prostata) si cancer
33. Nivelul de dihidrotestosteronul (DHT) 5a-dihidrotestosteron
5 5a-DHT are efect asupra virstei, testosteronul, estradiolul si estron
in stroma celulara a prostatei si hiperplazia celulelor stromale si
epiteliale la adenomul de prostata (hiperplazia benigna de prostata)
34. Plante pentru tulburarile de urinare
la adenomul de prostata (hiperplazia benigna de prostata): Saw Pallmetto,
Pygeum Africanum si Urzica (Nettle) = Prostata Formula
Metabolismul hormonal masculin: Restabilirea
echilibrului hormonal

35. Rolul de estrogeni si globulina - sex hormone-binding
globulin (SHBG) in fiziologia prostatei
36. Estradiolul activeaza receptorul androgen al prostatei
si secretia specifica a prostatei prin globulina - sex hormone-binding
globulin (SHBG)
37. Obezitatea, dieta, metabolismul de estrogen afectat: Dominanta
estrogenica cu riscul de cancer hormonal
Dominanta
estrogenica

Dieta anti-estrogenica indicat la cura
de slabire, suplimente nutritive cu specific anti-estrogenic: Indole-3-Carbinol,
Resveratrol, Diindolylmethane, Isoflavone si Prostata Formula
Dieta mediteraneana creste longevitatea,
studiile arata ca populatiile din tarile mediteraneene sint longevivi
38. Dieta mediteraneana traditionala reduce estrogenul
endogen la femei sanatoase in postmenopauza
39. Acizii grasi esentiali polinesaturati
Omega 3 din Ulei de Peste atenueaza cresterea cancerului mamar, prin
activarea neutrala de mediere a sfingomielinaza
Pestele cu ulei de peste contine acizi
grasi esentiali Omega 3 iar uleiul de masline contine acizi grasi mononesaturat Omega 9

Scurt si cuprinzator: acizii grasi esentiali
sint substante nutritive sanatoase pentru organism ca: Acizii grasi
polinesaturati Omega-3, Omega-6, Omega-9,
40. Barbatii obezi posed nivelul seric plasmatic ridicat
de estron sulfat
41. Nivelul seric de estradiol la barbati cu infarct
miocardic acut
Nivelul seric de estradiol la barbati
cu infarct miocardic acut

42. Asociatia de hiperestrogenemia cu cardiopatia ischemica
cronica la barbati
43. Evidenta de hiperestrogenemia un factor de risc in infarctul miocardic
la barbati
Echilibru hormonal pentru barbati si femei:
Diindolylmethane si Indole-3-Carbinol

| Bibliografie -References: Echilibru
hormonal |
 |
| Informatii din bibliografia electronica la tema:
Nutritie si sanatate |
1. Bradlow HL, et al. 1991. Effects of dietary indole-3-carbinol
on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis
12:1571-74.
- Bradlow HL, Michnovicz J, Telang NT, Osborne MP. Effects of dietary indole-3-carbinol
on estradiol metabolism and spontaneous mammary tumors in mice. Institute for
Hormone Research, New York, NY 10016. Carcinogenesis. 1991 Sep;12(9):1571-4.
2. Colditz GA. Estrogen, estrogen plus progestin therapy, and risk of breast
cancer. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital,
and Harvard Medical School, Boston, MA 02115. USA. Clin Cancer Res. 2005 Jan
15;11(2 Pt 2):909s-17s.
3.Beresford SA, Weiss NS, Voigt LF, McKnight B. Risk of endometrial cancer
in relation to use of oestrogen combined with cyclic progestagen therapy in
postmenopausal women. Departments of Epidemiology, University of Washington,
Seattle 98195-7236, USA. Lancet. 1997 Feb 15;349(9050):458-61.
- Beral V, Bull D, Reeves G; Million Women Study Collaborators. Endometrial
cancer and hormone-replacement therapy in the Million Women Study. Lancet.
2005 Apr 30-May 6;365(9470):1543-51.
4. Sturdee DW, Ulrich LG, Barlow DH, Wells M, Campbell MJ, Vessey MP, Nielsen
B, Anderson MC, Bragg AJ. The endometrial response to sequential and continuous
combined oestrogen-progestogen replacement therapy. Women's Health Unit, Birmingham
Heartlands and Solihull Hospital NHS Trust, West Midlands, UK. BJOG. 2000 Nov;107(11):1392-400.
- Sturdee DW, Ulrich LG, Barlow DH, Wells M, Campbell MJ, Vessey MP, Nielsen
B, Anderson MC, Bragg AJ. The endometrial response to sequential and continuous
combined oestrogen-progestogen replacement therapy. Women's Health Unit, Birmingham
Heartlands and Solihull Hospital NHS Trust, West Midlands, UK. BJOG 2001 Mar;108(3):335.
5. Moreno JG, Miller MC, Gross S, et al. Circulating tumor cells predict survival
in patients with metastatic prostate cancer. Urology. 2005 Apr;65(4):713-8.
6. Budd GT, Cristofanilli M, Ellis MJ, et al. Circulating tumor cells versus
imaging--predicting overall survival in metastatic breast cancer. Clin Cancer
Res. 2006 Nov 1;12(21):6403-9.
7. Beral V; Million Women Study Collaborators,
Bull D, Green J, Reeves G. Ovarian cancer and hormone replacement therapy in
the
Million Women Study. Million
Women Study Coordinating Centre, Cancer Research UK Epidemiology Unit, Richard
Doll Building, Roosevelt Drive, Oxford, OX3 7LF, UK. Lancet. 2007 May 19;369(9574):1703-10.
8. Rossouw JE, Prentice RL, Manson JE, Wu L, Barad D, Barnabei VM, Ko M, LaCroix
AZ, Margolis KL, Stefanick ML. Postmenopausal hormone therapy and risk of cardiovascular
disease by age and years since menopause. Women's Health Initiative Branch,
National Heart, Lung, and Blood Institute, Bethesda, Md 20892, USA. JAMA. 2007
Apr 4;297(13):1465-77.
9. Michnovicz JJ, Bradlow HL. Induction of estradiol metabolism by dietary
indole-3-carbinol in humans. J Natl Cancer Inst. 1990; 50:947-950.
10. Ritter CL, Prigge WF, Reichert MA, Malejka-Giganti D, "Oxidations
of 17 beta-estradiol and estrone and their interconversions catalyzed by liver,
mammary gland and mammary tumor after acute and chronic treatment of rats with
indole-3-carbinol or beta-naphthoflavone." Can J Physiol Pharmacol. 2001 Jun;79(6):519-32.
11. C L Hayes, D C Spink, B C Spink, J Q Cao, N J Walker, and T R Sutter 17
beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Department
of Environmental Health Sciences, Johns Hopkins University, School of Hygiene
and Public Health, Baltimore, MD 21205-2179, USA. Proc Natl Acad Sci U S A.
1996 September 3; 93(18): 9776–9781.
12. Jellinck PH, Forkert PG, Riddick DS, Okey AB, Michnovicz JJ, Bradlow HL.
Ah receptor binding properties of indole carbinols and induction of hepatic
estradiol hydroxylation. Department of Biochemistry, Queen's University, Kingston,
Ontario, Canada. Biochem Pharmacol. 1993 Mar 9;45(5):1129-36.
13. Chen I., et al., Indole-3-carbinol and diindolylmethane as aryl hydrocarbon
(AH) receptor agonists and antagonists in T47D human breast cancer cells. Biochemical
Pharmacology 1996; 51:1069-1076. 14. Chen I, McDougal A, Wang F, Safe S; "Aryl
hydrocarbon receptor-mediated antiiestrogenic and antitumorigenic activity
of diindolylmethane." Carcinogenesis 1998 Sep;19(9):1631-9.
8. Riby JE, Chang GH, Firestone GL, Bjeldanes LF. "Ligand-independent
activation of estrogen receptor function by 3,3'-diindolylmethane in human
breast cancer cells." Biochem Pharmacol. 2000 Jul 15;60(2):167-77.
15. Michnovicz JJ, et al., Changes in levels of urinary estrogen metabolites
after oral indole-3-carbinol treatment in humans. J Natl Cancer Inst. 1997
May 21; 89(10):718-23.
16. Bradlow HL, et al., 2-hydroxyestrone: the 'good' estrogen. J Endocrinol.
1996 Sep; 150 Suppl:S259-65.
17. Zhu BT, et al., Is 2-Methoxyestradiol an endogenous estrogen metabolite
that inhibits mammary carcinogenesis? Cancer Research 1998 June 1; 58:2269-2277
18.Arneson, DW, Hurwitz, A, McMahon, LM, and Robaugh, D: "Presence
of 3,3'-Diindolylmethane in human plasma after oral administration of Indole-3-carbinol." Proceedings of the American Association for Cancer Research, 1999 Mar; (40):
2833.
19. Rouzaud G, Young SA, Duncan AJ. Hydrolysis of glucosinolates to isothiocyanates
after ingestion of raw or microwaved cabbage by human volunteers. Cancer Epidemiol
Biomarkers Prev. 2004;13(1):125-131.
20. Leong H, Firestone GL, Bjeldanes LF, "Cytostatic
effects of 3,3-diindolylmethane in human endometrial cancer cells result from
an estrogen receptor-mediated increase in transforming growth factor-alpha
expression." Carcinogenesis. 2001 Nov;22(11):1809-17.
21. Arneson DW, Hurwitz A, Crowell JA, Mayo MS, "Pharmacokinetics
of 3-3'-Diindolylmethane following oral administration of Indole-3-carbinol
to human subjects." American Association of Cancer Research, (41) 2001, #4658.
22. Janet Tou, Chibo Hong and Leonard F. Bjeldanes,"The
Influence of 3'3-Diindolylmethane on Breast Tumor Growth, Invasion and Metastasis." Experimental Biology 2001, March 31-April 4, 2001, Orlando, Florida
23. Chibo Hong, Gary L. Firestone and Leonard F. Bjeldanes. "Induction
of apoptosis in MCF-7 and MDA-MB-231 human breast cancer cells by 3,3'-diindolylmethane
(DIM). " Experimental Biology 2001, March 31-April 4, 2001, Orlando, Florida.
24. Chibo Hong, Gary L. Firestone, and Leonard F. Bjeldanes, "3,3'-Diindolylmethane
(DIM), a dietary indole, has multiple cell suppressive effects on MCF-7, human
breast cancer cells." The American Society for Cell Biology, Fortieth Annual Meeting, December 2000,
San Francisco, California.
25. Hershcopf RJ, Bradlow HL. Obesity, diet, endogenous estrogens, and the
risk of hormone-sensitive cancer. Am J Clin Nutr. 1987 Jan;45(1 Suppl):283-9.
26. Chang YC, Riby J, Chang GH, Peng BC, Firestone G, Bjeldanes LF. Cytostatic
and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3'-diindolylmethane, a
major in vivo product of dietary indole-3-carbinol. Division of Nutritional
Sciences and Toxicology, University of California, Berkeley 94720, USA. Biochem
Pharmacol. 1999 Sep 1;58(5):825-34.
27. Munday R, Mhawech-Fauceglia P, Munday CM, Paonessa JD, Tang L, Munday
JS, Lister C, Wilson P, Fahey JW, Davis W, Zhang Y. Inhibition of urinary bladder
carcinogenesis by broccoli sprouts. AgResearch Limited, Ruakura Agricultural
Research Center, Hamilton, New Zealand. Cancer Res. 2008 Mar 1;68(5):1593-600.
Epub 2008 Feb 29.
28. Chen DZ, Qi M, Auborn KJ, Carter TH. Indole-3-carbinol and diindolylmethane
induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic
preneoplastic cervical epithelium. North Shore-Long Island Jewish Research
Institute, Manhasset, NY 11030, USA. J Nutr. 2001 Dec;131(12):3294-302.
29. Jang JJ, Cho KJ, Lee YS, Bae JH. Modifying responses of allyl sulfide,
indole-3-carbinol and germanium in a rat multi-organ carcinogenesis model.
Carcinogenesis 1991;4:691-695.
30. Nachshon-Kedmi M, Yannai S, Haj A, Fares FA. Indole-3-carbinol and 3,3'-diindolylmethane
induce apoptosis in human prostate cancer cells. Faculty of Food Engineering
and Biotechnology, Technion- Israel Institute of Technology, 32000, Haifa,
Israel. Food Chem Toxicol. 2003 Jun;41(6):745-52.
31. Frydoonfar HR, McGrath DR, Spigelman AD. The effect of indole-3-carbinol
and sulforaphane on a prostate cancer cell line. Discipline of Surgical Science,
Faculty of Health, The University of Newcastle, New South Wales, Australia.
ANZ J Surg. 2003 Mar;73(3):154-6.
32. Zeligs MA, Sepkovic DW, Manrique CA, Macksalka M, Williams DE, Bradlow
HL, "Absorption-enhanced
3,3-Diindolylmethane: human use in HPV-related, benign and pre-cancerous conditions." American Association of Cancer Research, (42) 2002, #103483.
33. Krieg M, Nass R, Tunn S. Effect of aging on endogenous level of 5 alpha-dihydrotestosterone,
testosterone, estradiol, and estrone in epithelium and stroma of normal and
hyperplastic human prostate. Institute of Clinical Chemistry and Laboratory
Medicine, University Clinic Bergmannsheil, Bochum, Germany. J Clin Endocrinol
Metab. 1993 Aug;77(2):375-81.
34. Dvorkin L, Song KY. Herbs for benign prostatic hyperplasia. Center for
Integrative Therapies in Pharmaceutical Care, Massachusetts College of Pharmacy
and Health Sciences, Boston, MA 02115-5896, USA. Ann Pharmacother. 2002 Sep;36(9):1443-52.
35. Farnsworth WE, Roles of estrogen and SHBG in prostate physiology. The Prostate
1996; 28:17-23.
36. Nakhla AM, Romas NA, Rosner W. Estradiol activates the prostate androgen
receptor and prostate-specific antigen secretion through the intermediacy of
sex hormone-binding globulin. Department of Medicine, St. Luke's/Roosevelt
Hospital Center, New York, New York 10019 and the College of Physicians and
Surgeons, Columbia University, New York, New York 10019, USA. J Biol Chem.
1997 Mar 14;272(11):6838-41.
37. Hershcopf RJ, Bradlow HL. Obesity, diet, endogenous estrogens, and the
risk of hormone-sensitive cancer. Am J Clin Nutr. 1987 Jan;45(1 Suppl):283-9.
38. Carruba G, Granata OM, Pala V, et al. A traditional Mediterranean diet
decreases endogenous estrogens in healthy postmenopausal women. Nutr Cancer.
2006;56(2):253-9.
39. Wu M, Harvey KA, Ruzmetov N, et al. Omega-3 polyunsaturated fatty acids
attenuate breast cancer growth through activation of a neutral sphingomyelinase-mediated
pathway. Int J Cancer. 2005 Nov 10;117(3):340-8.
40. Brind J, Strain G, Miller L, Zumoff B, Vogelman J, Orentreich N. Obese
men have elevated plasma levels of estrone sulfate. Orentreich Foundation for
the Advancement of Science Inc., Biomedical Research Station, Cold Spring-on-Hudson,
NY 10516. Int J Obes. 1990 Jun;14(6):483-6.
41. Klaiber EL, Broverman DM, Haffajee CI, Hochman JS, Sacks GM, Dalen JE.
Serum estrogen levels in men with acute myocardial infarction. Am J Med. 1982
Dec;73(6):872-81.
42. Phillips GB, Castelli WP, Abbott RD, McNamara PM. Association of hyperestrogenemia
and coronary heart disease in men in the Framingham cohort. Am J Med. 1983
May;74(5):863-9.
43. Philips GB, Evidence for hyperoestrogenaemia as a risk factor for myocardial
infarction in men. Lancet 1976; 2(7975): 14-18.
Parerea din pasajele acestui
site nu a fost independent cercetate sau confirmate
|