4 D-Pinitol
este sensibil la insulina, mediator de insulina in 3T3-L1 pre adipocite
D-Pinitol la reducerea tesutului adipos
5 D-Pinitol si derivatii sai Inositol (Myo-Inositol) plus Creatina (Creatine
Monohydrate) creste capacitatea de depozitare cu creatina musculara
mai mult ca
Creatina singura
D-Pinitol actioneaza via post receptor
insulinic, cu afectarea transmiterii semnalului intre sistemul kinazic
si sistemul transportor al glucozei insulino-dependente, GLUT-4
D-Pinitol mimeaza insulina ca medicamentele
de tipul (sulfoniluree) insa fara efecte adverse
6 D-Pinitol un inlocuitor de carbohidrati un produs natural antidiabetic
din planta (Bougainvillea spectabilis) care mimeaza insulina are efecte
similare insulinei si inbunatateste transportul de Creatina, Glucoza,
Amino
7 D-Pinitol cu efect tine glicemia sub control si factorii de risc cardiovasculari
D-Pinitol cu efect tine glicemia sub control
8 D-Pinitol cu efect reduce profilul lipidemic la diabetici cu rezistenta insulinica
Celule cu rezistenta insulinica
9 Metabolismul
la D-Pinitol in diabetul zaharat
10 D-Pinitol ( 3-O-methyl-D-chiro-Inozitol) un anti-hiperglicemic impreuna
cu Mangan la diabetici
11 Metabolismul si functiile Inozitolului cu fosfolipidele - Fosfatidil Inositol
12 D-Pinitol patentat in tratamentul sindromului metabolic indus de stresul
oxidativ de radicalul superoxid, previne disfunctia endoteliala la
diabetici
13 Inozitol (Myo-Inozitol) cu D-Pinitol in tratamentul sindromului metabolic
14 Disfunctia endoteliala la hiperglicemie induce ateroscleroza
15 Nivelul plasmatic de adiponectina si rezistenta insulinica la femei cu sindromul
ovarelor polichistice PCOS
16 D-Pinitol (3-O-Methyl-D-chiro-Inozitol) cu efect metabolic si de ovulatie la
sindromul ovarelor polichistice PCOS
PCOS cu chisturi ovariene
17 Inozitol (Myo-Inozitol) noa metoda pentru ovulatie la pacienti cu sindromul
ovarelor polichistice PCOS
18 D-Chiro-inozitol cu efect in functia de
ovulatie la sindromul
ovarelor polichistice PCOS si metabolic scade
concentratia serica de androgeni, nivelul seric de trigliceride,
tensiunea arteriala
19 D-Chiro-inozitol cu efect la sindromul
ovarelor polichistice PCOS
20 D-Chiro-inozitol schimba clearence-ul urinar la femei cu sindromul
ovarelor polichistice PCOS
21 D-Pinitol schimba metabolismul insulinemiei crescute la femei cu sau fara
sindromul ovarelor polichistice (PCOS)
La tratamentul de PCOS administrare D-Pinitol 600 mg 2 pe zi timp de 8 saptamini
deci 2 Fl de D-Pinitol Pro
D-Pinitol (3-O-Methyl-D-chiro-Inozitol) indicat la
reducerea nivelului lipidelor plasmatice, rezistenta la insulina ca
diabet zaharat cu complicatii de obezitate, hiperlipidemia si dislipidemia,
ateroscleroza,
hipertensiune, bolile cardiovasculare, AIDS, cancer, sepsis, stres,
lupus si alte boli autoimune, antiinflamator, poliartrita reumatoida,
boli endocrine, sindromul ovarelor polichistice (PCOS), hiperuricemia,
cresterea
activitatii
atletice.
Bibliografie - Referinte D-Pinitol
Informatii din bibliografia electronica la tema: Nutritie
si sanatate
1Singh RK, Pandey BL, Tripathi M, Pandey VB. Anti-inflammatory effect of (+)-pinitol.
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University,
-221005,
Varanasi, India. Fitoterapia. 2001 Feb;72(2):168-70.
2 Jun Sik Leea, In Duk Jungb, Young-Il Jeongc, Chang-Min Leeb, Yong Kyoo Shind,
Sang-Yull Leee, Dong-Soo Suhf, Man-Soo Yoonf, Kyu-Sub Leef, Yung
Hyun Choig, Hae Young Chunga and Yeong-Min Park d-pinitol inhibits Th1 polarization
via the suppression of dendritic cells. International Immunopharmacology
Volume 7, Issue 6, June 2007, Pages 791-804
3 Narayanan
C (1987) Pinitol-a new anti-diabetic compound from the leaves of Bougainvillea.
Curr Sci 56:76–78 .
4 Gyeong-Min
Do, Myung-Sook Choi, Hye-Jin Kim, Myung-Nam Woo, Mi-Kyung Lee, and Seon-Min Soy
pinitol acts partly as an insulin sensitizer or insulin mediator in 3T3-L1 preadipocytes
Genes Nutr. 2008 February; 2(4): 359–364.
5Greenwood
M, Kreider RB, Rasmussen C, Almada AL, Earnest CP. D-pinitol augments
whole
body creatine retention in man. J Exerc Physiol Online. 2001;4:41–47.
6 Bates
SH, Jones RB, Bailey CJ. (2000). Insulin-lik ffect of pinitol. British
Journal of Pharmacology, 130, 1944-1948
7 Kim
JI, Kim JC, Kang MJ, Lee MS, Kim JJ, Cha IJ. Effects of pinitol isolated
from soybeans on glycaemic control and cardiovascular
risk factors in Korean
patients with type II diabetes mellitus: a randomized
controlled study. Biohealth Product Research Center, School of Food
and Life Science, Institute for Food Sciences, Institute of Basic
Sciences,
Inje University, Gimhae,
Republic of Korea. Eur J Clin Nutr. 2005 Mar;59(3):456-8.
8 Geethan
PK, Prince PS. Antihyperlipidemic effect of D-pinitol on streptozotocin-induced
diabetic Wistar rats. Department of Biochemistry and Biotechnology,
Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India.
J Biochem Mol Toxicol. 2008 Jul;22(4):220-4.
9 Ostlund
RE Jr, McGill JB, Herskowitz I, Kipnis DM, Santiago JV, Sherman WR.
D-chiro-inositol metabolism in diabetes mellitus. Department of Medicine,
Washington
University, St. Louis, MO 63110. Proc Natl Acad Sci U S A. 1993
Nov 1;90(21):9988-92.
10 Fonteles
MC, Almeida MQ, Larner J. Antihyperglycemic effects of 3-O-methyl-D-chiro-inositol
and D-chiro-inositol associated with manganese in streptozotocin diabetic
rats. Clinical Research Unit, Federal University of Ceara/UECe,
National Research
Council (CNPq),
Fortaleza, Brazil. Horm Metab Res. 2000 Apr;32(4):129-32.
11 Holub
BJ. Metabolism and function of myo-inositol and inositol phospholipids. Annu
Rev Nutr. 1986;6:563-97.
12 Nascimento
NR, Lessa LM, Kerntopf MR, Sousa CM, Alves RS, Queiroz MG, Price J, Heimark
DB, Larner J, Du X, Brownlee M, Gow A, Davis
C, Fonteles MC. Inositols
prevent and reverse endothelial dysfunction in diabetic rat and rabbit
vasculature metabolically and by scavenging superoxide. College of Veterinary
Medicine,
State University of Ceará, Fortaleza, 60455-970 Ceará, Brazil.
Proc Natl Acad Sci U
S A. 2006 Jan 3;103(1):218-23. Epub 2005 Dec 22.
13 Ostlund,
Sherman; William R. Pinitol and derivatives thereof for the treatment of
metabolic disorders Washington University St. Louis, MO October
27, 1998
14 Nakagami
H, Kaneda Y, Ogihara T, Morishita R. Endothelial dysfunction in hyperglycemia
as a trigger of atherosclerosis. Division of Clinical Gene Therapy,
Osaka University
Graduate School of Medical, 2-2 Yamada-oka, Suita 565-0871, Japan. Curr Diabetes
Rev. 2005 Feb;1(1):59-63.
14 Ardawi
MS, Rouzi AA. Plasma adiponectin and insulin resistance in women with polycystic
ovary syndrome. Department of Clinical Biochemistry, Faculty
of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi
Arabia. Fertil Steril. 2005
Jun;83(6):1708-16.
15 Nestler
JE, Jakubowicz DJ, Reamer P, Gunn RD, Allan G. Ovulatory and metabolic effects
of D-chiro-inositol in the polycystic ovary syndrome. Department
of Medicine, Medical College of Virginia, Virginia Commonwealth
University, Richmond 23298-0111, USA. N Engl J Med. 1999 Apr 29;340(17):1314-20.
16 Papaleo
E, Unfer V, Baillargeon JP, De Santis L, Fusi F, Brigante C, Marelli
G, Cino I, Redaelli A, Ferrari A. Myo-inositol in patients with polycystic
ovary syndrome: a novel method for ovulation induction. IVF Unit, Gynaecological-Obstetric
Department, IRCCS San Raffaele Hospital, Vita-Salute University, Milan,
Italy. Gynecol Endocrinol. 2007 Dec;23(12):700-3. Epub 2007 Oct 10.
17 Nestler
JE, Jakubowicz DJ, Reamer P, Gunn RD, Allan G. Ovulatory and metabolic
effects of D-chiro-inositol in the polycystic ovary syndrome. Department
of Medicine,
Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0111,
USA. N Engl J Med. 1999 Apr 29;340(17):1314-20.
18 Iuorno
MJ, Jakubowicz DJ, Baillargeon JP, Dillon P, Gunn RD, Allan G, Nestler JE.
Effects of d-chiro-inositol in lean women with the
polycystic ovary syndrome.
Department
of Medicine, Medical College of Virginia, Virginia, Commonwealth University,
Richmond, Virginia, USA. Endocr Pract. 2002 Nov-Dec;8(6):417-23.
19 Baillargeon
JP, Diamanti-Kandarakis E, Ostlund RE Jr, Apridonidze T, Iuorno MJ,
Nestler JE. Altered D-chiro-inositol urinary clearance in women with polycystic
ovary syndrome. Department of Medicine, Université de Sherbrooke, Sherbrooke,
QC J1H 5N4, Canada. Diabetes Care. 2006 Feb;29(2):300-5.
20 Baillargeon
JP, Nestler JE, Ostlund RE, Apridonidze T, Diamanti-Kandarakis E.
Greek hyperinsulinemic women, with or without polycystic ovary syndrome,
display altered inositols metabolism. Department of Medicine, Universite
Sherbrooke,
Sherbrooke, Canada J1H 5N4. Hum Reprod. 2008 Jun;23(6):1439-46. Epub 2008
Mar 29.
D-Pinitol cu efect antiinflamator.
