Carnosina Terapia Anti Aging Longevitate
Carnosina de la Right Age ®
Terapia Anti Aging cu Carnosina
| Carnosina un miraculos supliment nutritional
Anti Aging - Carnosina elixirul tineretii |
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4. Carnosina cu proprietati fiziologice si potential terapeutic
Terapia Anti
Aging cu Carnosina
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Carnosina cu efect de
longevitate (Life Extension)
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5. Carnosina previne atrofia musculara de pina la 50%
in bolile sistemului neuromuscular si cel musculo-scheletal, cantitatea de
Carnosina scade in tesutul muscular
cu 63% intre 10-70 de ani
| Carnosina previne atrofia musculara, un produs foarte apreciat la sportivi si bodybuilder |
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| Mentinerea diametrului muscular |
Atrofie musculara |
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6. Concentratia
inalta de Carnosina cu efect in tesutul muscular la sprintul maximal pe ergometru
timp de 30 secunde
7. Efectul
de Carnosina si zinc chelat in functia musculara
8. Carnosina cu protectie a fibrelor musculare de oboseala
9. Spirulina
creste vitalitatea, prelungeste tineretea, intirzie imbatrinirea Anti Aging.
Spirulina
izvor de vitalitate prin mentinerea mediului anabolic datorita continutului
de: L-Arginina, L-Glutamina, L-Lizina, care are efect de eliberare naturala
de HGH Anti Aging.
Spirulina
pastreaza starea anabolica care este important in mentinerea diametrului
muscular, care scade pina la 40 % in atrofie musculara, daca nu se previne
procesul catabolic prin a creste masa musculara (efect anti-catabolic).
10. Carnosina
un Anti-Ageing antioxidant previne degradarea proteica (proteoliza), reactii
de carbonilare grupa de carbonil (> C=O) se leaga de moleculele de proteina,
rezulta oxidarea proteica
| Grupa de carbonil: Carnosina un
Anti-Ageing antioxidant previne degradarea proteica |
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11. Carnosina
si grupa de carbonil a proteinei o posibila relatie
12. Oxidarea proteinelor si inbatrinirea
13. Carnosina
reduce reactiile de glicozilare (AGEs) de incrucisare (crosslinking)
cu glucoza, Carnosine cu efect benefic reduce oxidarea proteinelor de
origine
animala
Ce nu va relateaza medicul despre diabet: Hemoglobina glicozilata
- (HbA1c) de 5% este valoarea optimala pentru controlul
metabolic si a logevitatii este reducerea glucozei la nivelul
de 70 - 80 mg/dl
Dar pentru managementul zilnic cu Self-monitoring Blood Glucose Profile
(SMBG) pentru ajustarea terapiei respectiv de Hemoglobina glicozilata -
hemoglobina A1c la 5% - 70 - 80 mg/dl valoarea optimala
Masurarea de Hemoglobina glicozilata - hemoglobina A1c nu este limitata
fata de variabilitatii glicemice
- Hemoglobina A1c nu diferentiaza glicemia de fasting - post, prandiala,
si postprandiala
14. Substante nutritive cu actiune de anti-glicozilare sint: Carnosina
si Acid Alfa Lipoic.
15. Carnosina
un supresor al virstei cu activitate de Longevitatee reduce oxidarea
proteinelor de origine animala care este un factor de risc pentru alte
patologii
16. Carnosina
reduce reactiile de glicozilare (AGEs) de incrucisare (crosslinking) cu
glucoza, Carnosine cu efect benefic reduce oxidarea proteinelor de origine
animala
17. Carnosina
reduce degradarea proteica (proteoliza) prin peroxidarea lipidica cauza
degradarii proteice, reduce reactiile de glicozilare (AGEs) de incrucisare
(crosslinking) cu glucoza si cu efect protectiv in rectiile de malonilare
- Glicozilare sint reactii necontrolate
ne-enzimatice ale glucozei cu proteinele
Carnosina inhiba reactiile de glicozilare
(AGEs), de brunificare si reducere a eslasticitatii
tesutului de colagen in procesul de imbatrinire
18. Carnosina
un protector proteinelor inhiba Metilglioxal in medierea de modificare
a proteinelor, Metilglioxal este un metabolit endogen care este prezent
la diabetici, se implica in reactiile de glicozilare (AGEs) si in complicatiile
diabetice
19. Carnosina
cu rol de inhibare a reactiilor de glicozilare
(AGEs), de brunificare si reducere a eslasticitatii tesutului de colagen
in procesul de imbatrinire
20. Carnosina
cu efect in tratamentul dupa accidentul vascular cerebral
21. Carnosina
cu efect in tratamentul atac ischemic tranzitor
22. Carnosina (b-alanil-L-histidina)
un natural antioxidant care neutralizeaza radicalii liberi hidroxil (OH),
oxigenul singlet (1-O2) si
inhiba peroxidarea lipidica
23. Teoria
radicalilor liberi in procesul de imbatrinire
Densitatea de neutralizare a radicalilor liberi
Capacitate scazuta de neutralizare a
radicalilor liberi
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24. Carnosina antioxidant cu efect protectiv
de moartea celulara cauzata de radicalii liberi
25. Suficienti
antioxidanti de recomandat: Carnosina, Acid Alfa Lipoic,
Ceai Verde, Coenzima Q10, Vitamina C, N-Acetilcisteina un precursor de
Glutation, Vitamin E,
Carotenoizi sau enzime antioxidante ca superoxid dismutaza care detoxifica
radicalul
superoxid,
peroxidul
de hidrogen (H2O2) si Glutation peroxidaza care detoxifica
peroxizii celulari
Capacitate suficienta de neutralizare a
radicalilor liberi
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| Antioxidantii neutralizeaza radicali
liberi |
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26. Carnosina are efect de inhibare a oxidarii lipoproteinelor
cu densitate joasa
27. N-Acetil
Carnosina un antioxidant de uz oftalmic in tratamentul cataractei
28. Adausul
de Carnosina la copii cu autism, studiu randomizat,
dublu-orb, placebo controlat
29. Carnosina cu potential in terapia
de scleroza amiotrofica laterala
30. Carnosina in mecanismul endogen de
neuroprotectie, un Age inhibitor indicat la dementa.
| Suplimente nutritive cerebrale |
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31. Carnosina cu efect de protectie a placilor de beta-amiloid
in boala Alzheimer
32. Carnosina
cu actiune de vindecare a ranilor
33. Carnosina
cu efect imunomodulator
34. Carnosina
un modulator intracelular al calciului in contractia celulei cardiace
35. Carnosina
cu efect in bolile cardovasculare
36. Carnosina
cu actiune de vasodilatare
37. Carnosina
reduce rata de scurtare telomerelor in cultura de fibroblast - celula a
tesutului conjunctiv nediferentiata
| Carnosina reduce rata de scurtare
telomerelor: Telomer (Telomere) se scurteza cu
diviziunea celulara |
Cromozom cu secvente de telomer la capat |
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| Carnosina creste rata de Telomer
(Telomere) cu fragmente scurtate (-) |
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| Fibroblast uman normal |
Fibroblast cu morfologie de
senescenta declin cognitiv |
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38. Carnosina
protector de ischemia cerebrala globala
39. Carnosina
cu efect de anti neoplasm
40. Carnosina
inhiba cresterea celulelor neoplazice
41. Stresul oxidativ de radicalii liberi
induc glicozilarea la pacienti cu boala pulmonara obstructiva cronica (COPD)
42. Stresul oxidativ prin radicalii liberi cresc glicozilarea
la hemoglobina in disfunctia renala
43. Nivelul de stres oxidativ prin radicalii liberi si glicozilarea proteinelor
la non diabetici pacientiilor cu disfunctie renala
44. Baza biochimica de complicatii la diabet prin formarea de AGEs (Advanced
glycosylation end products)
45. Reactia de incrucisare ( Cross-linking) de glicare a colagenului
in patogeneza arteriala si rigidizarea vaselor de singe care iriga inima
la inbatranire si diabet
46. Glicarea proteinelor, diabetul si imbatranirea
47. Reactia ne enzimatica de glucoza cu grupa amino de la proteine formind
AGEs este corelat cu fiziologia ambatranirii si diabetul sever
48. Reactia ne enzimatica de glicare a proteinelor in singe si la bolile
cardiovasculare
49. Cresterea glicozilarii hemoglobinei si proteinele plasmatice este
asociata cu cresterea nivelului peroxid la non diabetici
50. Carnosina
reduce reactiile de glicozilare (AGEs) de incrucisare
(crosslinking) cu glucoza, Carnosine cu efect benefic reduce oxidarea
proteinelor de origine animala
51. Reactia ne enzimatica de glicare a proteinelor in singe si la bolile
cardiovasculare
52. Cresterea glicozilarii hemoglobinei si proteinele plasmatice este
asociata cu cresterea nivelului peroxid la non diabetici
53. Carnosina un inhibitor al cu actiune de anti-glicozilare in hrana
proteica, inhiba imbatranirea si alte patologii
Terapia Anti Aging:
Anti-Aging-Systeme
- Formula
AntiAging
Dr.
MD. Roy L. Waldford,
Lisa Waldford - The Anti Aging Plan:
Strategies and Recipes for Extending
Your Healthy Years |
Crono
Forte - Formula Anti Aging
3 Capsule contine: 563 mg |
 |
Acetil-L-Carnitina 1000 mg,
Carnosine 500 mg,
Acid Alfa Lipoic 150 mg,
Glutation 30 mg,
Zinc 7,5 mg,
Biotina 1500 mcg
Seleniu 50 mcg, 30 Capsule
Total: 1689 mg: 3 = 563 mg o caps.
Mod
de administrare:
Crono Forte 1 x 1 Capsula pe zi
|
| Bibliografie-Referinte: |
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| Informatii din bibliografia electronica la tema: Nutritie si sanatate |
1. Hipkiss AR, Brownson C. A
possible new role for the anti-ageing peptide carnosine.Biomolecular
Sciences Division, GKT School of Biomedical Sciences, King's College London,
UK. Cell Mol Life Sci. 2000 May;57(5):747-53.
2. Hipkiss AR, Preston JE, Himsworth DT,
Worthington VC, Keown M, Michaelis J, Lawrence J, Mateen A, Allende L, Eagles
PA, Abbott NJ. Pluripotent
protective effects of carnosine, a naturally occurring dipeptide. Molecular
Biology and Biophysics Group, King's College London, Strand, United Kingdom.
Ann N Y Acad Sci. 1998 Nov 20;854:37-53.
- Boldyrev AA, Gallant SC, Sukhich GT. Carnosine,
the protective, anti-aging peptide. Center for Molecular Medicine, Department
of Biochemistry, Biological Faculty, MV Lomonosov, Moscow State University, Vorobjovy
Gory, Russia. Biosci Rep. 1999 Dec;19(6):581-7.
3. Gallant S, Semyonova M, Yuneva M. Carnosine
as a potential anti-senescence drug. Zoetic Neurosciences Ltd., Leighton
Buzzard, Beds, LU7 7NW, Great Britain. Biochemistry (Mosc). 2000 Jul;65(7):866-8.
4. Gariballa SE, Sinclair AJ. Carnosine:
physiological properties and therapeutic potential. Sheffield Institute
of Studies on Ageing, The University of Sheffield, Barnsley General Hospital,
UK.
Age Ageing. 2000 May;29(3):207-10.
5. Stuerenburg HJ. The
roles of carnosine in aging of skeletal muscle and in neuromuscular diseases.
Biochemistry (Mosc). 2000 Jul;65(7):862-5.
6. Suzuki Y, Ito O,
Mukai N, Takahashi H, Takamatsu K. High
level of skeletal muscle carnosine contributes to the latter
half of exercise performance during 30-s maximal cycle ergometer
sprinting. Doctoral Program in Health and Sport Sciences,
University of Tsukuba, Japan. Jpn J Physiol. 2002 Apr;52(2):199-205.
7. Tameyasu T, Yamada
M, Tanaka M, Takahashi S. Effect
of zinc-carnosine chelate compound on muscle function in
mdx mouse. Department of Physiology, St. Marianna University
School of Medicine, Kawasaki, 216-8511 Japan. t2tame@marianna-u.ac.jp.
Jpn J Physiol. 2002 Feb;52(1):111-20.
8. Rubtsov AM. Molecular
mechanisms of regulation of the activity of sarcoplasmic reticulum Ca-release
channels (ryanodine receptors), muscle fatigue, and Severin's phenomenon. Department
of Biochemistry, School of Biology, Lomonosov Moscow State University, Moscow,
119899, Russia. am_rubtsov@mail.ru. Biochemistry (Mosc). 2001 Oct;66(10):1132-43.
9. Bulik, C. 1993.
How the Spirulina, a green-blue alga, preserves
de cell from degeneration, and extends youth and human
lifespan. In: Doumenge, F., Durand-Chastel, H., Toulemont, A., Eds.
Spiruline algue de vie.
10. Hipkiss AR, Brownson C, Carrier
MJ. Carnosine,
the anti-ageing, anti-oxidant
dipeptide, may react with protein carbonyl groups. Division of Biomolecular
Sciences, GKT School of Biomedical Sciences, King's College London, Guy's Campus,
London
Bridge, London SE1 1UL, UK.
Mech Ageing Dev. 2001 Sep 15;122(13):1431-45.
11.
Hipkiss AR. Carnosine
and protein carbonyl groups: a possible relationship. Division of Biomolecular
Sciences, GKT School of Biomedical Sciences, King's College London, London
SE1 1UL, UK. Biochemistry (Mosc). 2000 Jul;65(7):771-8.
12. Berlett BS, Stadtman ER. Protein
oxidation in aging, disease, and oxidative stress. J Biol Chem. 1997; 272(33):20313-6.
- Stadtman ER. Protein
oxidation and aging. Science. 1992; 257(5074):1220-4.
13. Hipkiss AR. Glycation,
ageing and carnosine: are carnivorous diets beneficial Centre for Experimental
Therapeutics, William Harvey Research Institute, John Vane Science Centre,
Bart's and the London Queen Mary's School of Medicine and Dentistry, Charterhouse
Square, London EC1M 6BQ, UK. Mech Ageing Dev. 2005 Oct;126(10):1034-9.
14. DeGroot J. The AGE of the matrix: chemistry, consequence and cure. Director
of
Matrix Biology Research Group, TNO Prevention and Health, TNO Pharma, Division
of Biomedical Research, PO Box 2215, 2301 CE Leiden, The Netherlands.
Curr Opin Pharmacol. 2004 Jun;4(3):301-5.
15. Hipkiss AR. Would
carnosine or a carnivorous diet help suppress aging and associated pathologies
Centre for Experimental Therapeutics, William Harvey Research Institute, Barts'
and the London School of Medicine and Dentistry, UK. Ann N Y Acad Sci. 2006
May;1067:369-74.
16. Hipkiss AR, Michaelis J, Syrris
P. Non-enzymatic
glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking
agent. FEBS Lett. 1995; 371(1):81-5.
- Burcham PC, Kuhan YT. Diminished
susceptibility to proteolysis after protein modification by the lipid peroxidation
product malondialdehyde: inhibitory role for crosslinked and noncrosslinked adducted
proteins. Arch Biochem Biophys. 1997; 340(2):331-7.
- Brownson C, Hipkiss AR. Carnosine
reacts with a glycated protein. Division of Biomolecular Science, GKT School
of Biomedical Sciences, King's College London, Guy's Campus, London Bridge, London,
UK. Free Radic Biol Med. 2000 May 15;28(10):1564-70.
Hipkiss AR, Preston JE, Himswoth DT, Worthington VC, Abbot NJ. Protective
effects of carnosine against malondialdehyde-induced toxicity towards cultured
rat brain endothelial cells. Molecular Biology and Biophysics Group, King's
College London, Strand, UK. Neurosci Lett. 1997 Dec 5;238(3):135-8.
- Hipkiss AR, Worthington VC, Himsworth DT, Herwig W. Protective
effects of carnosine against protein modification mediated by malondialdehyde
and hypochlorite. Molecular Biology and Biophysics Group, King's College
London, UK. Biochim Biophys Acta. 1998 Mar 12;1380(1):46-54.
- Bierhaus A, Hofmann MA, Ziegler R, Nawroth PP. AGEs
and their interaction with AGE-receptors in vascular disease and diabetes mellitus.
I.
The AGE concept. Department of Medicine I, University of Heidelberg, Germany.
Cardiovasc Res. 1998 Mar;37(3):586-600.
17. Burcham PC, Kuhan YT. Diminished
susceptibility to proteolysis after protein modification by the lipid peroxidation
product malondialdehyde: inhibitory role for crosslinked and noncrosslinked
adducted proteins. Arch Biochem Biophys. 1997; 340(2):331-7.
- Brownson C, Hipkiss AR. Carnosine
reacts with a glycated protein. Division of Biomolecular Science, GKT School
of Biomedical Sciences, King's College London, Guy's Campus, London Bridge, London,
UK. Free Radic Biol Med. 2000 May 15;28(10):1564-70.
- Hipkiss AR, Michaelis J, Syrris P. Non-enzymatic
glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking
agent. FEBS Lett. 1995; 371(1):81-5.
Hipkiss AR, Preston JE, Himswoth DT, Worthington VC, Abbot NJ. Protective
effects of carnosine against malondialdehyde-induced toxicity towards cultured
rat brain
endothelial cells. Molecular Biology and Biophysics Group, King's College
London,
Strand, UK. Neurosci Lett. 1997 Dec 5;238(3):135-8.
- Hipkiss AR, Worthington
VC, Himsworth DT, Herwig W. Protective
effects of carnosine against protein modification mediated by malondialdehyde
and hypochlorite. Molecular Biology and Biophysics Group, King's College
London, UK. Biochim Biophys Acta. 1998 Mar 12;1380(1):46-54.
- Bierhaus A, Hofmann MA, Ziegler R, Nawroth PP. AGEs
and their interaction with AGE-receptors in vascular disease and diabetes mellitus.
I.
The AGE concept. Department of Medicine I, University of Heidelberg, Germany.
Cardiovasc Res. 1998 Mar;37(3):586-600.
18. Hipkiss AR, Chana H. Carnosine
protects proteins against methylglyoxal-mediated modifications. Molecular
Biology and Biophysics Group, King's College London, United Kingdom. Biochem
Biophys Res Commun. 1998 Jul 9;248(1):28-32.
19. Thorpe SR, Baynes JW. Role
of the Maillard reaction in diabetes mellitus and diseases of aging. Department
of Chemistry and Biochemistry, University of South Carolina, Columbia 29208,
USA. Drugs Aging. 1996 Aug;9(2):69-77.
- David L. Price, Patricia M. Rhett, Suzanne R. Thorpe, and John W. BaynesDagger.
Chelating
Activity of Advanced Glycation End-product Inhibitors. From the Department
of Chemistry and Biochemistry, University of South Carolina, Columbia, South
Carolina 29208. J. Biol. Chem., Vol. 276, Issue 52, 48967-48972, December 28,
2001
20. Gallant S, Kukley M, Stvolinsky
S, Bulygina E, Boldyrev A. Effect
of carnosine on rats under experimental brain ischemia. Zoetic Neurosciences
Ltd., England, UK. Tohoku J Exp Med. 2000 Jun;191(2):85-99.
21. Stvolinsky
SL, Dobrota D.Anti-ischemic
activity of carnosine. Laboratory of Clinical Neurochemistry,
Institute of Neurology, Russian Academy of Medical Sciences,
Moscow, 123367 Russia. Biochemistry (Mosc). 2000 Jul;65(7):849-55.
- Suslina ZA, Federova TN, Maksimova MIu, Riasina TV, Stvolinskii
SL, Khrapova
EV, Boldyrev AA. Antioxidant
therapy in ischemic stroke Zh Nevrol Psikhiatr Im S S Korsakova. 2000;100(10):34-8.
22. Babizhayev MA, Seguin MC, Gueyne
J, Evstigneeva RP, Ageyeva EA, Zheltukhina GA. L-carnosine
(beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural
antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities.
Moscow Helmholtz Research Institute of Eye Diseases, Russia. Biochem J. 1994
Dec 1;304
( Pt 2):509-16.
- Decker EA, Livisay SA, Zhou S. A
re-evaluation of the antioxidant activity of purified carnosine. Department
of Food Science, Chenoweth Lab, University of Massachusetts, Amherst, MA 01003,
USA. edecker@foodsci.umass.edu. Biochemistry (Mosc). 2000 Jul;65(7):766-70.
- Chan WK, Decker EA, Chow CK, Boissonneault GA. Effect
of dietary carnosine on plasma and tissue antioxidant concentrations and on lipid
oxidation in rat skeletal muscle. Department of Animal Sciences, University
of Massachusetts, Amherst 01003. Lipids. 1994 Jul;29(7):461-6.
- Hartman PE, Hartman Z, Ault KT. Scavenging
of singlet molecular oxygen by imidazole compounds: high and sustained activities
of carboxy terminal histidine dipeptides and exceptional activity of imidazole-4-acetic
acid. Department of Biology, Johns Hopkins University, Baltimore, MD 21218.
Photochem Photobiol. 1990 Jan;51(1):59-66.
- Yoshikawa T, Naito Y, Tanigawa T, Yoneta T, Kondo M. The
antioxidant properties of a novel zinc-carnosine chelate compound, N-(3-aminopropionyl)-L-histidinato
zinc. First Department of Medicine, Kyoto Prefectural University of Medicine,
Japan. Biochim Biophys Acta. 1991 Nov 14;1115(1):15-22.
- Gulyaeva NV, Dupin AM, Levshina IP. Carnosine
prevents activation of free-radical lipid oxidation during stress. Bull Exp
Biol Med. 1989; 107(2):148-152.
- Gulyaeva NV. Superoxide-scavenging activity of carnosine in the presence of
copper and zinc ions. Biochemistry (Moscow). 1987; 52(7 Part 2):1051-4.
23. Beckman, K. & Ames, B. (1998) "The
free radical theory of aging matures" Physiol
Rev 78: 548-81.
24. Boldyrev A, Song R, Lawrence
D, et
al. Carnosine
protects against excitotoxic cell death independently of effects on reactive
oxygen species. Neuroscience. 1999; 94(2):571-7.
- MacFarlane N, McMurray J, O'Dowd JJ, Dargie HJ, Miller DJ. Synergism
of histidyl dipeptides as antioxidants. Institute of Physiology, Glasgow
University, UK. J Mol Cell Cardiol. 1991 Nov;23(11):1205-7.
25. Chan WK, Decker EA, Chow CK,
Boissonneault
GA. Effect
of dietary carnosine on plasma and tissue antioxidant concentrations and on lipid
oxidation in rat skeletal muscle. Department of Animal Sciences, University
of Massachusetts, Amherst 01003. Lipids. 1994 Jul;29(7):461-6.
- Kang JH, Kim KS, Choi SY, Kwon HY, Won MH, Kang TC. Protection
by carnosine-related dipeptides against hydrogen peroxide-mediated ceruloplasmin
modification. Department of Genetic Engineering, Chongju University, Korea.
Mol Cells. 2002 Feb 28;13(1):107-12
26. Decker EA, Ivanov V, Zhu BZ,
Frei
B. Inhibition
of low-density lipoprotein oxidation by carnosine histidine. Department of
Food Science, Chenoweth Laboratory, University of Massachusetts, Amherst 01003,
USA. J Agric Food Chem. 2001 Jan;49(1):511-6.
27. Babizhayev MA, Yermakova VN,
Semiletov
YA, Deyev AI. The
natural histidine-containing dipeptide Nalpha-acetylcarnosine as an antioxidant
for ophthalmic use. Innovative Vision Products Inc., County of New Castle,
Delaware 19810, USA. (Mosc). 2000 May;65(5):588-98.
- Babizhayev MA, Yermakova VN, Sakina NL, Evstigneeva RP, Rozhkova
EA, Zheltukhina GA. N
alpha-acetylcarnosine is a prodrug of L-carnosine in ophthalmic application as
antioxidant. Moscow Helmholtz Research Institute of Eye Diseases, Russian
Federation. Clin Chim Acta. 1996 Oct 15;254(1):1-21.
- Babizhayev MA, Deyev AI, Yermakova VN, Semiletov YA, Davydova
NG, Kurysheva NI, Zhukotskii AV, Goldman IM. N-Acetylcarnosine,
a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment
of human cataracts. Innovative Vision Products, Inc., County of New Castle,
DE 19810, USA. markbabizhayev@mail.ru Peptides. 2001 Jun;22(6):979-94.
- Babizhayev MA, Deyev AI, Yermakova VN, Brikman IV, Bours J.
Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to
manage
age-related cataracts in human and in canine eyes. Innovative Vision Products
Inc., County of New Castle, Delaware, USA. Drugs
R D. 2004;5(3):125-39.
28. Chez
MG, Buchanan CP, Aimonovitch MC, Becker M, Schaefer
K, Black C, Komen J. Double-blind,
placebo-controlled study of L-carnosine supplementation
in children with autistic spectrum disorders. Research
Division, Autism and Epilepsy Specialty Services
of Illinois, Ltd, Lake Bluff, IL 60044, USA. mchezmd@interaccess.com
J Child Neurol. 2002 Nov;17(11):833-7.
29. Kang JH, Eum
WS. Enhanced
oxidative damage by the familial amyotrophic lateral sclerosis-associated
Cu,Zn-superoxide dismutase mutants. Biochim Biophys Acta.
2000 Dec 15;1524(2-3):162-70.
30. Horning MS, Blakemore
LJ, Trombley PQ. Endogenous
mechanisms of neuroprotection: role of zinc, copper, and
carnosine. Brain Res. 2000; 852(1):56-61.
- Stvolinsky SL, Kukley ML, Dobrota D, et al. Carnosine:
an endogenous neuroprotector in the ischemic brain. Cell
Mol Neurobiol. 1999; 19(1):45-56.
- Boldyrev AA, Stvolinsky SL, Tyulina OV, et al. Biochemical and physiological
evidence that carnosine is an endogenous neuroprotector against free radicals.
Cell Mol Neurobiol. 1997; 17(2):259-71.
- Dukic-Stefanovic S, Schinzel R, Riederer P, Munch G. AGES in brain ageing:
AGE-inhibitors
as neuroprotective and anti-dementia drugs Physiological Chemistry I, Biocenter,
University of Wurzburg, Germany. Biogerontology. 2001;2(1):19-34.
31. Preston JE, Hipkiss AR, Himsworth
DT, Romero IA, Abbott JN. Toxic
effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell:
protection
by
carnosine, homocarnosine and beta-alanine. Institute of Gerontology, King's
College
London, UK. Neurosci Lett. 1998 Feb 13;242(2):105-8.
- Munch G, Schinzel R, Loske C, et al. Alzheimer's
disease-synergistic effects of glucose deficit, oxidative stress and advanced
glycation endproducts. Journal
of Neural Transmission. 1998; 105(4-5):439-61.
32. Nagai K, Suda T, Kawasaki K,
Mathuura S. Action
of carnosine and beta-alanine
on wound healing. Surgery. 1986 Nov;100(5):815-21
33. Nagai K, Suda T. Immunoregulative
effects of carnosine and beta-alanine Nippon Seirigaku Zasshi. 1986;48(6):564-71.
34. Zaloga GP, Roberts
PR, Black KW, Lin M, Zapata-Sudo G, Sudo RT, Nelson TE. Carnosine
is a novel peptide modulator of intracellular calcium and
contractility
in cardiac cells. Department of Anesthesia, Bowman Gray School of Medicine,
Wake Forest University, Winston-Salem, North Carolina 27157, USA. Am J Physiol.
1997 Jan;272(1 Pt 2):H462-8.
35. Roberts PR, Zaloga GP. Cardiovascular
effects of carnosine. Department of Anesthesiology, Wake Forest University
School of Medicine, Winston-Salem, NC 27157-1009, USA. Biochemistry (Mosc).
2000
Jul;65(7):856-61.
36. Ririe DG, Roberts PR, Shouse
MN,
Zaloga GP. Vasodilatory
actions of the dietary peptide carnosine. Department of Anesthesiology, Wake
Forest University School of Medicine, Winston-Salem, NC 27157-1009, USA.
Nutrition.
2000 Mar;16(3):168-72.
37. Shao L, Li QH, Tan Z. L-carnosine
reduces telomere damage and shortening
rate in cultured normal fibroblasts. Institute of Zoology, Chinese Academy
of
Sciences, Beijing 100080, PR China. Biochem Biophys Res Commun. 2004 Nov 12;324(2):931-6.
38. Stvolinsky S, Kukley M, Dobrota
D,
Mezesova V, Boldyrev A. Carnosine
protects
rats under global ischemia. Laboratory of Neurochemistry, Institute of Neurology,
Russian Academy of Medical Sciences, Moscow, Russia. Brain Res Bull. 2000 Nov
1;53(4):445-8.
39. Nagai K, Suda T. Antineoplastic
effects of carnosine and beta-alanine--physiological considerations of its antineoplastic
effects Nippon Seirigaku Zasshi. 1986;48(11):741-7.
40. Holliday R, McFarland GA. Inhibition
of the growth of transformed and neoplastic cells by the dipeptide carnosine.
CSIRO Division of Biomolecular Engineering, Sydney Laboratory, NSW, Australia.
Br J Cancer. 1996 Apr;73(8):966-71.
41. Parija M, Bobby Z, Kumar V, Saradha B. Oxidative stress and protein glycation
in patients with chronic obstructive pulmonary disease. Department of Biochemistry,
Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry
- 605 006. Indian J Physiol Pharmacol. 2005 Jan;49(1):95-8.
42. Selvaraj N, Bobby Z, Sridhar MG. Increased glycation of hemoglobin in chronic
renal failure: potential role of oxidative stress. Department of Biochemistry,
Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry,
India. Arch Med Res. 2008 Apr;39(3):277-84.
43. Selvaraj N, Bobby Z, Das AK, Ramesh R, Koner BC. An evaluation of level of
oxidative stress and protein glycation in nondiabetic undialyzed chronic renal
failure patients. Department of Biochemistry, Jawaharlal Institute of Postgraduate
Medical Education and Research, Pondicherry 605006, India. Clin Chim Acta. 2002
Oct;324(1-2):45-50.
44. Bjorksten J, Tenhu H. The crosslinking theory of aging--added evidence. Bjorksten
Research Foundation, Madison, Wisconsin. Exp Gerontol. 1990;25(2):91-5.
45. Aronson D. Cross-linking of glycated collagen in the pathogenesis of arterial
and myocardial stiffening of aging and diabetes. Department of Cardiology, Rambam
Medical Center, POB 9602, Haifa 31096, Israel. J Hypertens. 2003 Jan;21(1):3-12
46. Ulrich P, Cerami A. Protein glycation, diabetes, and aging. The Kenneth S
Warren, Laboratories, Tarrytown, New York 10591, USA. Recent Prog Horm Res. 2001;56:1-21
47. Bousova I, Vukasovic D, Juretic D, Palicka V, Drsata J. Enzyme activity and
AGE formation in a model of AST glycoxidation by D-fructose in vitro. Department
of Biochemical Sciences, Charles University in Prague Faculty of Pharmacy, Hradec
Kralove, Czech Republic. Acta Pharm. 2005 Mar;55(1):107-14.
48. Misciagna G, De Michele G, Trevisan M. Non enzymatic glycated proteins in
the blood and cardiovascular disease. Laboratory of Epidemiology, IRCCS S. De
Bellis, Castellana (Bari) 70013, Italy. Curr Pharm Des. 2007;13(36):3688-95
49. Sathiyapriya V, Selvaraj N, Nandeesha H, Bobby Z, Agrawal A, Pavithran P.
Enhanced glycation of hemoglobin and plasma proteins is associated with increased
lipid peroxide levels in non-diabetic hypertensive subjects. Department of Biochemistry,
Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry,
India. Arch Med Res. 2007 Nov;38(8):822-6. Epub 2007 Aug 23.
50. Hipkiss AR. Glycation, ageing and carnosine: are carnivorous diets beneficial
Centre for Experimental Therapeutics, William Harvey Research Institute, John
Vane Science Centre, Bart's and the London Queen Mary's School of Medicine and
Dentistry, Charterhouse Square, London EC1M 6BQ, UK. Mech Ageing Dev. 2005 Oct;126(10):1034-9.
51. Misciagna G, De Michele G, Trevisan M. Non enzymatic glycated proteins in
the blood and cardiovascular disease. Laboratory of Epidemiology, IRCCS S. De
Bellis, Castellana (Bari) 70013, Italy. Curr Pharm Des. 2007;13(36):3688-95.
52, Sathiyapriya V, Selvaraj N, Nandeesha H, Bobby Z, Agrawal A, Pavithran P.
Enhanced glycation of hemoglobin and plasma proteins is associated with increased
lipid peroxide levels in non-diabetic hypertensive subjects. Department of Biochemistry,
Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry,
India. Arch Med Res. 2007 Nov;38(8):822-6. Epub 2007 Aug 23.
53. DeGroot J. The AGE of the matrix: chemistry, consequence and cure. Director
of Matrix Biology Research Group, TNO Prevention and Health, TNO Pharma, Division
of Biomedical Research, PO Box 2215, 2301 CE Leiden, The Netherlands. Curr Opin
Pharmacol. 2004 Jun;4(3):301-5.
Literatura:
Dr.
Ronald Klatz, MD. Robert Goldman - Stopping the Clock: Dramatic Breakthroughs
in Anti Aging and Aging Reversal Techniques
Dr.
MD. Roy L Waldford - Beyond the 120 Year Diet: How to Double Your Vital
Years
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