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Acid Elagic un fenol din plante naturale cu actiune anticancer si anti mutagenica.
| Radicalii liberi produc stres oxidativ | Distrugerile ADN-ului de radicalii liberi care produc stres oxidativ |
 |
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33
Acid Elagic cu compozitie
de polifenol inhiba receptori PDGF si VEGF
34 Acid
Elagic un potent inhibitor de hOAT1
35 Acid
Elagic cu activitate antibacteriala de stafilococi (Staphylococcus
aureus)
36 Acid
Elagic inhiba activitatea la P450 si nitrosamine specifice de tutun
37 Acid
Elagic un potent produs natural anticancer
Terapia Anti Aging:
Anti-Aging-Systeme
- Formula
AntiAging
Bibliografie - Referinte Acid Elagic
Informatii din bibliografia electronica la tema: Nutritie si sanatate
1 Maas,
J.L., S.Y. Wang., G.J. Galletta. 1991a. Evaluation of strawberry genotypes
for ellagic acid, an antimutagenic and anticarcinogenic plant phenol.
In: The Strawberry Into the 21st Century, A. Dale and J.J. Luby, editors. Timber
Press.
p. 115-117.
2 Funt, R.C.; Bash, W.D.; Schwartz, S.J; Collier, J and G. Wenneker. 1997. Small
fruit cultivar characteristics for ellagic acid and nutraceutical development.
Proceedings Ohio Fruit and Vegetable Growers Congress. pp 110-114.
- American Academy of Pediatrics Committee on Nutrition. Vitamin and mineral
supplement needs of normal children in the United States. Pediatrics 66:1015-1020,
1980.
3 Yu YM, Chang WC, Wu CH, Chiang SY. Reduction of oxidative stress and apoptosis
in hyperlipidemic rabbits by ellagic acid. Department of Nutrition, China Medical
University, Taichung, Taiwan. yuyamei@hotmail.com J Nutr Biochem. 2005 Nov;16(11):675-81.
Epub 2005 Aug 2.
4 Majid S, Khanduja KL, Gandhi RK, Kapur S, Sharma RR. Influence of ellagic
acid on antioxidant defense system and lipid peroxidation in mice. Department
of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh,
India. Biochem Pharmacol. 1991 Sep 12;42(7):1441-5.
- Osawa, T., Ide, A., Su, J. D., and Namiki, M., Inhibition of lipid peroxidation
by ellagic acid. J. Agric. Food Chem., 35, 808–812
- Ashoori F, Suzuki S, Zhou JH, Isshiki N, Miyachi Y. Involvement of lipid peroxidation
in necrosis of skin flaps and its suppression by ellagic acid. Department of
Plastic and Reconstructive Surgery, Kyoto University Hospital, Japan. Plast Reconstr
Surg. 1994 Dec;94(7):1027-37.
5 Barch
DH, Rundhaugen LM, Thomas PE, Kardos P, Pillay NS. Dietary ellagic acid inhibits
the enzymatic activity of CYP1A1 without altering hepatic concentrations
of CYP1A1 or CYP1A1 mRNA. Department of Medicine, Lakeside Veterans Affairs Medical
Center, Northwestern University Medical School, Chicago, Illinois.
Biochem Biophys Res Commun. 1994 Jun 30;201(3):1477-82.
6 Thresiamma KC, George J, Kuttan R. Protective effect of curcumin, ellagic
acid and bixin on radiation induced genotoxicity. Amala Cancer Research Centre,
Amala Nagar, Trichur, Kerala State, India. J Exp Clin Cancer Res. 1998 Dec;17(4):431-4.
- Lesca, P: Protective effects of ellagic acid and other plant phenols on benzo(a)pyrene-induced
neoplasia in mice. Carcinogenesis 4:1651-1653, 1983.
7 Mertens-Talcott SU, Talcott ST, Percival SS. Low concentrations of quercetin
and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis
in MOLT-4 human leukemia cells. Food Science and Human Nutrition Department,
University of Florida, Gainesville, FL 32611, USA. J Nutr. 2003 Aug;133(8):2669-74.
8 S. Mertens-Talcott, S. Percival Ellagic acid and quercetin interact synergistically
with resveratrol in the induction of apoptosis and cause transient cell cycle
arrest in human leukemia cells. Department of Food Science and Human Nutrition,
Institute of Food and Agricultural Sciences, University of Florida, P.O. Box
110370, Gainesville, FL 32611-0370, USA Cancer Letters, Volume 218, Issue 2,
Pages 141-151
9 Iakovleva LV, Ivakhnenko AK, Buniatian ND. The protective action of ellagic
acid in experimental myocarditis Central Research Laboratory, Ukranian Pharmaceutical
Academy, Kharkov, Ukraine. Eksp Klin Farmakol.
1998 May-Jun;61(3):32-4.
10 Doyle B, Griffiths LA. The metabolism of ellagic acid in the rat. Xenobiotica.
1980 Apr;10(4):247-56.
11 Lei F, Xing DM, Xiang L, Zhao YN, Wang W, Zhang LJ, Du LJ. Pharmacokinetic
study of ellagic acid in rat after oral administration of pomegranate leaf extract.
Institute of Medicinal Plant, Peking Union Medical College, Chinese Academy of
Medical Sciences, Beijing 100094, China. J Chromatogr B Analyt Technol Biomed
Life Sci. 2003 Oct
25;796(1):189-94.
12 Cerda B, Ceron JJ, Tomas-Barberan FA, Espin JC. Repeated oral administration
of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days
is not toxic. J Agric Food Chem. 2003 May
13 Jeune MA, Kumi-Diaka J, Brown J. Anticancer activities of pomegranate extracts
and genistein in human breast cancer cells. Department of Biological Sciences,
Charles E. Schmidt College of Science, Florida Atlantic University, Davie, FL
33314-7714, USA. celestre@iwon.com J Med Food. 2005 Winter;8(4):469-75.
14 Albrecht M, Jiang W, Kumi-Diaka J, Lansky EP, Gommersall LM, Patel A, Mansel
RE, Neeman I, Geldof AA, Campbell MJ. Pomegranate extracts potently suppress
proliferation, xenograft growth, and invasion of human prostate cancer cells.
Institute of Anatomy and Cell Biology, Philipps University, Marburg, Germany.
J Med Food. 2004 Fall;7(3):274-83.
15 Yoshimura M, Watanabe Y, Kasai K, Yamakoshi J, Koga T. Inhibitory effect
of an ellagic acid-rich pomegranate extract on tyrosinase activity and ultraviolet-induced
pigmentation. Research and Development Division, Kikkoman Corporation, Noda City,
Chiba, Japan. myoshimura@mail.kikkoman.co.jp Biosci Biotechnol Biochem. 2005
Dec;69(12):2368-73.
16 Shimogaki,
H., Tanaka, Y., Tamai, H., and Masuda, M., In vitro and in vivo evaluation
of ellagic acid on melanogenesis inhibition. Int. J. Cosmet. Sci.,
22, 291–303 (2000).
17 Aslam MN, Lansky EP, Varani J. Pomegranate as a cosmeceutical source: pomegranate
fractions promote proliferation and procollagen synthesis and inhibit matrix
metalloproteinase-1 production in human skin cells. Department of Pathology,
The University of Michigan Medical School, 1301 Catherine Road/Box 0602, Ann
Arbor, MI 48109, USA. J Ethnopharmacol. 2006 Feb 20;103(3):311-8. Epub 2005 Oct
10.
18 Afaq F, Saleem M, Krueger CG, Reed JD, Mukhtar H. Anthocyanin- and hydrolyzable
tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and
inhibits skin tumorigenesis in CD-1 mice. Department of Dermatology, University
of Wisconsin, Madison, WI 53706, USA. Int J Cancer. 2005 Jan 20;113(3):423-33.
19 Khan N, Hadi N, Afaq F, Syed DN, Kweon MH, Mukhtar H. Pomegranate fruit extract
inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth
in athymic nude mice. Department of Dermatology, University of Wisconsin Madison,
WI 53706, USA. Carcinogenesis. 2007 Jan;28(1):163-73. Epub
2006 Aug 18.
- Boukharta M, Jalbert G, Castonguay A. Biodistribution of ellagic acid and dose-related
inhibition of lung tumorigenesis in A/J mice. Laboratory of Cancer Etiology and
Chemoprevention, School of Pharmacy, Laval University, Quebec City, Canada. Nutr
Cancer. 1992;18(2):181-9.
20 Khan N, Afaq F, Kweon MH, Kim K, Mukhtar H. Oral consumption of pomegranate
fruit extract inhibits growth and progression of primary lung tumors in mice.
Department of Dermatology and Biostatistics and Medical Informatics, University
of Wisconsin Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin-Madison,
Madison, Wisconsin, USA. Cancer Res. 2007 Apr 1;67(7):3475-82. Epub 2007 Mar
27.
- Khan N, Afaq F, Kweon MH, Kim K, Mukhtar H. Oral consumption of pomegranate
fruit extract inhibits growth and progression of primary lung tumors in mice.
Department of Dermatology and Biostatistics and Medical Informatics, University
of Wisconsin Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin-Madison,
Madison, Wisconsin, USA. Cancer Res. 2007 Apr 1;67(7):3475-82. Epub 2007 Mar
27.
21 Adhami VM, Mukhtar H. Polyphenols from green tea and pomegranate for prevention
of prostate cancer. Department of Dermatology, University of Wisconsin-Madison,
Madison, WI 53706, USA. Free Radic Res. 2006 Oct;40(10):1095-104.
22 Seeram NP, Aronson WJ, Zhang Y, Henning SM, Moro A, Lee RP, Sartippour M,
Harris DM, Rettig M, Suchard MA, Pantuck AJ, Belldegrun A, Heber D. Pomegranate
ellagitannin-derived metabolites inhibit prostate cancer growth and localize
to the mouse prostate gland. J Agric Food Chem. 2007 Sep 19;55(19):7732-7. Epub
2007 Aug 28.
23 Falsaperla
M, Morgia G, Tartarone A, Ardito R, Romano G. Support ellagic acid therapy in
patients with hormone refractory prostate cancer (HRPC) on standard
chemotherapy using vinorelbine and estramustine phosphate. Operative Unit of
Urology, Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture,
Potenza, Italy. mayurol@yahoo.it Eur Urol. 2005 Apr;47(4):449-54; discussion
454-5. Epub 2005 Jan 19.
24 Mandal
S, Stoner GD. Inhibition of N-nitrosobenzylmethylamine-induced esophageal tumorigenesis
in rats by ellagic acid. Department of Pathology, Medical College
of Ohio, Toledo 43699. Carcinogenesis. 1990 Jan;11(1):55-61.
25 Siglin JC, Barch DH, Stoner GD. Effects of dietary phenethyl isothiocyanate,
ellagic acid, sulindac and calcium on the induction and progression of N-nitrosomethylbenzylamine-induced
esophageal carcinogenesis in rats. Department of Pathology, Medical College of
Ohio, Toledo 43699-0008, USA. Carcinogenesis. 1995 May;16(5):1101-6.
26 Tanaka T, Iwata H, Niwa K, Mori Y, Mori H. Inhibitory effect of ellagic acid
on N-2-fluorenylacetamide-induced liver carcinogenesis in male ACI/N rats. First
Department of Pathology, Gifu University School of Medicine. Jpn J Cancer Res.
1988 Dec;79(12):1297-303.
27 Ahn D, Putt D, Kresty L, Stoner GD, Fromm D, Hollenberg PF. The effects of
dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and
phase II enzymes. Department of Surgery, Wayne State University, Detroit, MI
48201, USA. Carcinogenesis. 1996 Apr;17(4):821-8.
28 Thresiamma KC, Kuttan R. Inhibition of liver fibrosis by ellagic acid. Amala
Cancer Research Centre, Amala Nagar, Trichur, Kerala. Indian J Physiol Pharmacol.
1996 Oct;40(4):363-6.
29 Narayanan BA, Geoffroy O, Willingham MC, Re GG, Nixon DW. p53/p21(WAF1/CIP1)
expression and its possible role in G1 arrest and apoptosis in ellagic acid treated
cancer cells. Cancer Prevention Program, Hollings Cancer Center, Medical University
of South Carolina, Charleston 29425, USA. bhagavati@musc.edu Cancer Lett. 1999
Mar 1;136(2):215-21.
30 Narayanan BA, Re GG. IGF-II down regulation associated cell cycle arrest
in colon cancer cells exposed to phenolic antioxidant ellagic acid. American
Health Foundation, 1, Dana Road Valhalla, NY 10595, USA. bhagavat@earthlink.net
Anticancer Res. 2001 Jan-Feb;21(1A):359-64.
31 Festa F, Aglitti T, Duranti G, Ricordy R, Perticone P, Cozzi R. Strong antioxidant
activity of ellagic acid in mammalian cells in vitro revealed by the comet assay.
Dipartimento di Biologia, Universita degli Studi Roma TRE, Italy. Anticancer
Res. 2001 Nov-Dec;21(6A):3903-8.
- Barch DH, Rundhaugen LM. Ellagic acid induces NAD(P)H:quinone reductase through
activation of the antioxidant responsive element of the rat NAD(P)H:quinone reductase
gene. Department of Medicine, Lakeside Veterans Affairs Medical Center, Chicago,
IL. Carcinogenesis. 1994 Sep;15(9):2065-8.
32 Pavlica
S, Gebhardt R. Protective effects of ellagic and chlorogenic acids against
oxidative stress in PC12 cells. Institut fur Biochemie, Medizinische
Fakultat, Universitat Leipzig, Liebigstr. 16, Leipzig, 04103, Germany. Free
Radic Res. 2005 Dec;39(12):1377-90.
33 Labrecque
L, Lamy S, Chapus A, Mihoubi S, Durocher Y, Cass B, Bojanowski MW, Gingras D,
Beliveau R. Combined inhibition of PDGF and VEGF receptors by
ellagic acid, a dietary-derived phenolic compound. Laboratoire de Medecine Moleculaire,
Hopital Ste-Justine-Universite du Quebec a Montreal, Centre de Cancerologie Charles-Bruneau,
3175 Chemin Cote-Ste-Catherine, Montreal, Quebec, Canada H3T 1C5. Carcinogenesis.
2005 Apr;26(4):821-6. Epub 2005 Jan 20.
34 Whitley AC, Sweet DH, Walle T. The dietary polyphenol ellagic acid is a potent
inhibitor of hOAT1. Department of Cell and Molecular Pharmacology and Experimental
Therapeutics, Medical University of South Carolina, 173 Ashley Avenue, Charleston,
SC 29425, USA. wallet@musc.edu Drug Metab Dispos. 2005 Aug;33(8):1097-100. Epub
2005 May 3.
35 Akiyama H, Fujii K, Yamasaki O, Oono T, Iwatsuki K. Antibacterial action
of several tannins against Staphylococcus aureus. Department of Dermatology,
Okayama University Graduate School of Medicine and Dentistry, Shikata-cho 2-5-1,
Okayama 700-8558, Japan. akiyamah@cc.okayama-u.ac.jp J Antimicrob Chemother.
2001 Oct;48(4):487-91.
- Lu HF, Tsou MF, Lin JG, Ho CC, Liu JY, Chuang JY, Chung JG. Ellagic acid inhibits
growth and arylamine N-acetyltransferase activity and gene expression in Staphylococcus
aureus. Department of Clinical Pathology, Cheng Hsin Rehabilitation Medical Center,
Taipei, Taiwan. In Vivo. 2005 Jan-Feb;19(1):195-9.
36 Zhang Z, Hamilton SM, Stewart C, Strother A, Teel RW. Inhibition of liver
microsomal cytochrome P450 activity and metabolism of the tobacco-specific nitrosamine
NNK by capsaicin and ellagic acid. Department of Physiology and Pharmacology,
School of Medicine, Loma Linda University, CA 92350. Anticancer Res. 1993 Nov-Dec;13(6A):2341-6.
37 Mukhtar H, Del Tito BJ, Marcelo CL, Das M, Bickers DR. Ellagic acid: a potent
naturally occurring inhibitor of benzo[a]pyrene metabolism and its subsequent
glucuronidation, sulfation and covalent binding to DNA in cultured BALB/C mouse
keratinocytes. Carcinogenesis. 1984;5(12):1565-1571.
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