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- Inalta concentratie de oxigen reactiv - radicalii liberi si cantitatea insuficienta in organism de antioxidanti, genera in organite (centrale energetice celulare) eficacitatea scazuta a repararii ADN-ului, ca rezultat: Disfunctia mitocondriala, care este o caracteristica a celulelor maligne. 32
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Anticancer-Oncoxin cu Germaniu Organic (GE-132) in activitatea anticancer la activarea importanta de macrofage si celulele T.
| Radicalii liberi produc stres oxidativ | Distrugerile ADN-ului de radicalii liberi care produc stres oxidativ |
 |
 |
- Mutatiile ADN-ului de radicalii liberi afecteaza energia celulara ATP Administrarea de antioxidanti ca factor anti cancer determina reversia fenotipului malign prin inhibarea celulelor de cancer - Anti cancer: EGCG Galatul de epigalocatechina
| Degradarea ADN-ului prin acumularea de 8-hidroxi-2’-deoxiguanozina | Reversia fenotipului malign prin inhibarea celulelor de cancer |
 |
 |
Neutralizarea de radicali liberi - Densitatea antioxidativa
Despre antioxidanti: Antioxidantii sint molecule care apara
organismul de efectele oxigenului reactiv - Radicalii liberi
Radicalii liberi produc stres oxidativ, iar antioxidantii apara celula de radicalii
liberi care sint molecule instabile, contin electroni neimperecheati, adica
un electron ocupa un singur orbital.
33
Ceai
Verde cu EGCG - Galatul de epigalocatechina extr. stand.
50% are activitate antioxidanta de neutralizare de radicali liberi:
radicalul superoxid (O2-), radicalul peroxil (RO2-),
radicalul peroxinitrit (OONO -), peroxid de hidrogen (H2O2)
previne oxidarea LDL - biologia si medicina radicalilor liberi
34 Ceai
Verde cu EGCG - Galatul de epigalocatechina extr. stand.
50% are activitate antioxidanta de neutralizare a
radicalilor liberi, inhiba peroxidarea lipidelor, degradarea ADN-ului,
in 8-hidroxi-2’-deoxiguanozina (8-OHdG), este un biomarker a stresului
oxidativ, acumulata in ADN cauzeaza disfunctia mitocondriala si criza energetica
Disfunctia mitocondriala care este o caracteristica a celulelor maligne, datorat prin capacitatea scazuta antioxidativa.
| Antioxidantii apara celula de efectele oxigenului reactiv | Antioxidantii cu neutralizarea de radicali liberi - Capacitate scazuta antioxidativa |
 |
 |
- Antioxidanti se gasesc in orice celula, protejeaza organismul
de distrugerile provocate la nivel celular de radicalii liberi.
- Antioxidantii pot neutraliza radicalii liberi limitind distrugerea provocata,
daca suficienti antioxidanti sint involvati - Capacitate suficienta antioxidativa
- Acid Alfa Lipoic prin proprietati si functie regenereaza alti antioxidanti
ca: Vitamina C, Vitamina E, Glutation, Coenzima Q10 ofera protectie antioxidativa
de efectele radicalilor liberi.
Antioxidantii protejind celula de radicalii liberi - Capacitate suficienta
Sint o multime de antioxidanti in extracte de plante naturale, fitofarmaceutice, nutraceutice cu capacite de neutralizare a radicalilor liberi Antioxidanti cheie: Acid Alfa Lipoic, Coenzima Q10, Vitamine: Vitamina C, Vitamina E, Caretenoizi, (beta caroten,alfa caroten, licopen, luteina, zeaxantina) Compusi fenolici: Flavonoizi, polifenoli care confera protectie ridicata antoxidativa
- Suficienti antioxidanti de recomandat: Acid Alfa Lipoic, Ceai Verde EGCG, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H 2O2) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari
Spirulina contine
superoxid dismutaza (SOD) un antioxidant puternic 110000 Unitati/100g
Suficienti antioxidanti de recomandat: Acid alfa lipoic, Ceai Verde, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H2O2) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari
EGCG cu capacitate de absorbtie a radicalului liber a oxigenului - ORAC, comparatia valorilor fata de Vitamina C
36 Vitamina
D3 - 800 UI/zi si Calciu 1800 mg/zi cu potential in preventia de cancer mamar
si cancer de colon
37 Vitamina
D3 1000 UI mediaza transcrierea genei prin receptorul Vitamina D (VDR) si
transfoma celulele epiteliale de Cancer mamar in celule normale
38 Vitamina D3 un modulator in cresterea de cancer
mamar
39 Vitamina D3 in preventia
de cancer mamar
40 Vitamina
D3 regleaza receptorul Vitamina D (VDR) care inhiba linia celulara HT29 si
MCF-7 la cancerul mamar si cancerul
de colon
41 Vitamina
D3 si Melatonina cresteTGF-beta-1 si induce inhibarea de cancer mamar
42 Suplimente
nutritionale de Vitamina D in preventia de cancer mamar la femei in menopauza
43 Vitamina
D3 1000 UI mediaza la regresia la tumora
44 Vitamina
D atenueaza cresterea de tumora retinoblastoma tumorala cu inducerea apoptozei
celulare de cancer
45 Vitamina
D in preventia de cancer de prostata
Terapia Anti-Aging:
Anti-Aging-Systeme
- Terapia Anti-Aging
Bibliografie-Referinte: ANTICANCER-ONCOXIN
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