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Produse		Naturale

Termenul ortomolecular a fost folosit prima data de Linus Pauling

7. Vitamine Antioxidante pentru preventia de boli cardiovasculare, studiu randomizat dublu orb placebo controlat

18. Acetil L-Carnitina un: Elixir al tineretii - Acetil L-Carnitina (ALC) + Acid Alfa Lipoic (AAL) prin reducerea de stres oxidativ si a oxidarii ADN/ARN se incetineste procesul de inbatrinire la mitocondria care este uzina energetica de ATP

Carnitina acetiltransferaza are afinitate si activitate in cerebral prin Acetil L-Carnitina (ALC) + Acid Alfa Lipoic (AAL) efect Anti Aging

Acetil L-Carnitina un: Elixir al tineretii - Acetil L-Carnitina (ALC) si Acid Alfa Lipoic (AAL)

19. Acetil L-Carnitina cu efect Anti Aging, restaureaza functia mitocondriala si activitatea ambulatorie

37. Carnosina cu rol de inhibare a reactiilor de glicozilare (AGEs), de brunificare si reducere a eslasticitatii tesutului de colagen in procesul de imbatrinire

38. Carnosina si Beta Alanina cu efect de protectie cerebrala de toxicul beta-amiloid in boala Alzheimer

39. Carnosina reduce rata de scurtare de telomere in cultura de fibroblast - celula a tesutului conjunctiv nediferentiata

Carnosina reduce rata de scurtare telomerelor: Telomer (Telomere) se scurteza cu diviziunea celulara	Cromozom cu secvente de telomer la capat

40. Inhibarea enzimei de telomeraza, care reface telomere la capetele cromozomului

Carnosina creste rata de Telomer (Telomere) cu fragmente scurtate (-)

Fibroblast uman normal	Fibroblast cu morfologie de senescenta declin cognitiv

41. Carnosina intirzie senescenta si efect de intinerire (rejuvenating effects) in cultura de fibroblast

42. Controlul Telomer (Telomere) si senescenta imbatranirea celulara, rolul telomerazei

Scurtarea de telomere este ceasul molecular care declanseaza senescenta (telomere shortening is the molecular clock that triggers senescence)

43. Anti-Imbatranire: Longevitatea (Extension of life span) prin introducerea de telomeraza in celula umana.

 

Anti-Aging-Systeme - Formula AntiAging

Bibliografie-Referinte: Anti-Aging

Informatii din bibliografia electronica la tema: Nutritie si sanatate

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5. Velicer CM, Ulrich CM. Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review. Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle, WA 98109, USA. J Clin Oncol. 2008 Feb 1;26(4):665-73.
6. Fletcher RH, Fairfield KM. Vitamins for chronic disease prevention in adults: clinical applications. Department of Ambulatory Care and Prevention, Harvard Medical School/Harvard Pilgrim Health Care, 133 Brookline Ave, Sixth Floor, Boston, MA 02215, USA. JAMA. 2002 Jun 19;287(23):3127-9.
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- Hagen TM, Wehr CM, Ames BN. Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-alpha-phenyl-nitrone.Department of Molecular and Cell Biology, University of California at Berkeley 94720, USA. tory.hagen@orst.edu Ann N Y Acad Sci. 1998 Nov 20;854:214-23.
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Liu J, Killilea DW, Ames BN. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid. Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720, USA. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1876-81
19. Hagen TM, Ingersoll RT, Wehr CM, Lykkesfelt J, Vinarsky V, Bartholomew JC, Song MH, Ames BN, Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity.Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA. Proc Natl Acad Sci USA (United States) August 4, 1998, 95 (16) p.9562-6.
20. Paradies G; Petrosillo G; Gadaleta MN; Ruggiero FM., The effect of aging and acetyl-L-carnitine on the pyruvate transport and oxidation in rat heart mitochondria.Department of Biochemistry and Molecular Biology, University of Bari, Italy. FEBS Lett Netherlands Jul 9 1999, 454 (3) p207-9.
21. 15. Brooks JO 3rd, Yesavage JA, Carta A, Bravi D, Stanford University School of Medicine, California, USA. Acetyl-L-carnitine slows decline in younger patients with Alzheimer's Disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach. Int. Psychogeriatr (United States) June 1998, 10 (2) p.193-203.
22. Amenta F, Ferrante F, Lucreziotti R, Ricci A, Ramacci MT, Reduced lipofuscin accumulation in senescent rat brain by long-term acetyl-L-carnitine treatment. Dipartimento di Scienze Neurologiche, Universita La Sapienza, Rome, Italy. Arch Gerontol Geriatr 1989 Sep-Oct;9(2):147-53.
23. Calvani M, Arrigoni-Martelli E., Sigma-Tau S.p.A, Pomezia, Rome, Italy. Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion. Int J Tissue React 1999;21(1):1-6.
24. Lolic MM, Fiskum G, Rosenthal RE, Neuroprotective effects of acetyl-L-carnitine after stroke in rats. Department of Emergency Medicine, Ronald Reagan Institute of Emergency Medicine, Washington, DC USA. Ann Emerg Med (United States) June 1997, 29 (6) p.758-65.
25. Swamy-Mruthinti S; Carter AL., Acetyl-L-carnitine decreases glycation of lens proteins: in vitro studies. Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912-2100, USA. Exp Eye Res (England) Jul 1999, 69 (1) p109-15.
26. Soneru IL, Khan T, Orfalian Z, Abraira C. Acetyl-L-carnitine effects on nerve conduction and glycemic regulation in experimental diabetes. Extended Care & Geriatrics Service (181c), Hines VA Hospital, Illinois 60641, USA. Endocr Res (United States) Feb-May 1997,23, (1-2) p.27-36.
27. Hipkiss AR, Brownson C. A possible new role for the anti-ageing peptide carnosine.Biomolecular Sciences Division, GKT School of Biomedical Sciences, King's College London, UK. Cell Mol Life Sci. 2000 May;57(5):747-53.
28. Hipkiss AR, Preston JE, Himsworth DT, Worthington VC, Keown M, Michaelis J, Lawrence J, Mateen A, Allende L, Eagles PA, Abbott NJ. Pluripotent protective effects of carnosine, a naturally occurring dipeptide. Molecular Biology and Biophysics Group, King's College London, Strand, United Kingdom. Ann N Y Acad Sci. 1998 Nov 20;854:37-53.
- Boldyrev AA, Gallant SC, Sukhich GT. Carnosine, the protective, anti-aging peptide. Center for Molecular Medicine, Department of Biochemistry, Biological Faculty, MV Lomonosov, Moscow State University, Vorobjovy Gory, Russia. Biosci Rep. 1999 Dec;19(6):581-7.
29. Gallant S, Semyonova M, Yuneva M. Carnosine as a potential anti-senescence drug. Zoetic Neurosciences Ltd., Leighton Buzzard, Beds, LU7 7NW, Great Britain. Biochemistry (Mosc). 2000 Jul;65(7):866-8.
30. Hipkiss AR, Brownson C, Carrier MJ. Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups. Division of Biomolecular Sciences, GKT School of Biomedical Sciences, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK. Mech Ageing Dev. 2001 Sep 15;122(13):1431-45.
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32.Hipkiss AR. Glycation, ageing and carnosine: are carnivorous diets beneficial. Centre for Experimental Therapeutics, William Harvey Research Institute, John Vane Science Centre, Bart's and the London Queen Mary's School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK. Mech Ageing Dev. 2005 Oct;126(10):1034-9.
33. Hipkiss AR. Would carnosine or a carnivorous diet help suppress aging and associated pathologies. Centre for Experimental Therapeutics, William Harvey Research Institute, Barts' and the London School of Medicine and Dentistry, UK. Ann N Y Acad Sci. 2006 May;1067:369-74.
34. Hipkiss AR, Michaelis J, Syrris P. Non-enzymatic glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking agent. FEBS Lett. 1995; 371(1):81-5.
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Hipkiss AR, Preston JE, Himswoth DT, Worthington VC, Abbot NJ. Protective effects of carnosine against malondialdehyde-induced toxicity towards cultured rat brain endothelial cells. Molecular Biology and Biophysics Group, King's College London, Strand, UK. Neurosci Lett. 1997 Dec 5;238(3):135-8.
- Hipkiss AR, Worthington VC, Himsworth DT, Herwig W. Protective effects of carnosine against protein modification mediated by malondialdehyde and hypochlorite. Molecular Biology and Biophysics Group, King's College London, UK. Biochim Biophys Acta. 1998 Mar 12;1380(1):46-54.
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35. Burcham PC, Kuhan YT. Diminished susceptibility to proteolysis after protein modification by the lipid peroxidation product malondialdehyde: inhibitory role for crosslinked and noncrosslinked adducted proteins. Arch Biochem Biophys. 1997; 340(2):331-7.
- Brownson C, Hipkiss AR. Carnosine reacts with a glycated protein. Division of Biomolecular Science, GKT School of Biomedical Sciences, King's College London, Guy's Campus, London Bridge, London, UK. Free Radic Biol Med. 2000 May 15;28(10):1564-70.
- Hipkiss AR, Michaelis J, Syrris P. Non-enzymatic glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking agent. FEBS Lett. 1995; 371(1):81-5.
Hipkiss AR, Preston JE, Himswoth DT, Worthington VC, Abbot NJ. Protective effects of carnosine against malondialdehyde-induced toxicity towards cultured rat brain endothelial cells. Molecular Biology and Biophysics Group, King's College London, Strand, UK. Neurosci Lett. 1997 Dec 5;238(3):135-8.
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