Tonice - Energizante naturale

Refacerea functiei mitocondriale

Mitocondria Formula + Q10

1 Mitocondria ceasul biologic

2 Refacerea functiei mitocondriale

Elementele structurale ale mitocondriei sunt: membrane externa, compartimentul intermembranar, membrana interna si compartimentul mitocondrial intern (matrice).

Mitocondria este responsabila de generarea de energiei

Fiecare component joaca un rol important in organit, prin functiile pe care le indeplineste.

Mitocontriile sunt organite celulare

Creatina este metabolizata in Creatina Fosfat, ingredientul esential care converteste Adenozin-difosfat ADP in adenozin-trifosfat (ATP) prin enzimele localizate pe cristele mitocondriale.

Disfunctia mitocondriala

3 Melatonina previne disfunctia mitocondriala cerebrala via protectiei de cardiolipina

4 Melatonina cu efect de protectie la disfunctia mitocondriala asociat cu cardioprotectia din ischemia - reperfuzia, rolul de cardiolipina

Mitocondrii exista in toate celulele, produc energia utilizata de organism

Mitocondria este numit si uzina energetica a materiei vii, activeaza producerea de Adenozin-trifosfat (ATP)

Mitocondria cu producerea de energie este o necesitate absoluta pentru rezistenta fizica, energie, si viata insasi.

Cea mai mica scadere a productiei de energie mitocondriala, poate duce la slabiciune, oboseala si dificultati cognitive

Mitochondria uzina energetica a materiei vii

1. Intermediari adecvati al: Ciclul acidului citric si Beta oxidaza

3. Lantul respirator (lant transportor de electroni) cu enzimele mitocondriale: Complex I-IV

4. Complex V - ATP sintaza (ATP synthase)

Producerea de energie mitocondriala prin doua procese metabolice:

- Ciclul acidului citric (Krebs cicle) sau ciclul tricarboxilic - (Fig. 2)

- Fosforilarea oxidativa (OXPHOS)

- Ciclul acidului citric (Krebs cicle) (Fig. 2) converteste glucidele si acizii grasi in Adenozin-trifosfat (ATP) ) care este principala sursa de energie celulara.

- Fosforilarea oxidativa (OXPHOS) combina hidrogenul cu oxigenul pentru a genera sume mai mari de Adenozin-trifosfat (ATP) , Fosforilarea oxidativa (OXPHOS) genereaza de 10 ori mai mult ATP de cit ciclul acidului citric, fosforilatia oxidativa este o energie primara pentru toate organismele aerobe

- Fosforilarea oxidativa (OXPHOS) mitocondriala prevede folosirea de 80% de Adenozin-trifosfat (ATP) in celule.

5 Controlul lantului respirator (lant transportor de electroni) si sinteza de Adenozin-trifosfat (ATP) la celule mitocondriale

- Fosforilarea oxidativa functioneaza prin lantul respirator (lant transportor de electroni) un lant cu cinci complexe proteice (I-V) in membrana interioara din mitochondria

Peretii mitocondriali sunt formati dintr-o membrana externa si interna (Fig. 3)

Primele patru complexe apartin lantului respirator (lantul transportor de electroni). Ultimul complex proteic se mai numeste si ATP sintaza si este localizat transmembranar.

Aceste complexe au un rol important in functionarea unui proces important, numit fosforilarea oxidativa.

Enzimele mitocondriale

- Complex I - NADH dehidrogenaza (NADH dehydrogenase)

- Complex II - Succinat dehidrogenaza (succinate dehydrogenase)

- Complex III - Citocrom C reductaza (cytochrome-c reductase) are in alcatuirea sa un singur polipeptid mitocondrial (citocromul b)

- Complex IV - Citocrom C oxidaza (cytochrome-c oxidase) - Citocromoxidaza

- Complex V - ATP sintaza (ATP synthase)

Fosforilarea oxidativa (Fig. 4) converteste Adenozina-difosfat (ADP) in Adenozin-trifosfat (ATP) care apoi poate fi transportata la locul necesar.

Deficitul balantei energetice in relatie cu fosforilarea oxidativa (OXPHOS), boli mitocondriale la varstnici

6 Lantul respirator mitocondrial la celulele hepatice descreste la varstnici

7 Deficienta de Coenzima Q10 in mitocondria

8 Coenzima Q10 si activitatea Complexului II - Succinat dehidrogenaza

9 Coenzima Q10 interactioneaza cu Complex I - NADH dehidrogenaza, Complexul II - Succinat dehidrogenaza si Complex III - Citocrom C reductaza (cytochrome-c reductase) are in alcatuirea sa un singur polipeptid mitocondrial (citocromul b)

10 Eficienta mitocondriala, productia de energie, functia scade si activitatea lantului respirator scade cu varsta la celulele muschiului scheletal de inima si ficat

11 Complex IV - Citocrom C oxidaza la cardiomiocitele umane ale inimii este un fenomen al varstei, studiu

12 Complex IV - Citocrom C oxidaza cu fibre musculare deficiente la celula musculare este un fenomen de alteratie al varstei

13 Pierderea progresiva a Complexului IV - Citocrom C oxidaza la celulele musculare oculare la varstnici, studiu

- Eficienta mitocondriala, productia de energie si functia scade cu varsta (Fig. 4) se acumuleaza dovezi ca disfunctia mitocondriala sta la baza multor boli legate de varsta inclusiv Parkinson, Alzheimer, boli cardiace, sindrom de oboseala cronica (CFS)

- Schimbarile care au loc in mitochondria include:

14 Disfunctia mitocondriala si deteriorarea mitocondriala ADN-ului de radicalii liberi la varstnici

- Scaderea eficientei cilului krebs datorita modificari ca raspuns la cererile de energie pe termen lung,

Disfunctia mitocondriala

15 Mitocondria musculara sa schimba la varstnici

Mitocondria la adultii tineri sanatosi raspunde diferit la cerinta de energie decit cei mai in varsta

Mitocondria la adultii tineri sanatosi se adapteaza si creste rapid cerintele de energie

Ca rezultat mitocondrii multiple produc mai mult Adenozin-trifosfat (ATP) pentru energie

Cu inaintarea varstei se reduce numarul de mitocondrii pentru a produce energie

Diminuarea numarului de mitocondrii in la varstnici

Scaderea activitatii citocrom-c oxidaza

16 Modificarea lantului respirator mitocondrial la varstnici

17 Mitocondriala se schimba cu varsta aspecte moleculare si implicatii fizio patologice

ADN-ul Mitocondrial este expus lezarilor oxidative

18 Fosforilarea oxidativa declina la varstnici - Medicina mitocondriala

Efectul radicalilor liberi asupra structurii membranelor mitocondriale

19 Mutatia ADN-ului mitocondrial contribuie la imbatranire si boli degenerative

Lantul respirator declina datorita modificarea enzimelor mitocondriale

20 Analiza functiei lantului respirator mitocondrial si actiunea distructiva ADN-ului mitocondrial la muschiul scheletal la varstnici

Actiuni distructive ADN-ului mitocondrial creste exponential

21 Doua trepte a mutatiei ADN mitocondriale

22 Rolul structurii Membranei mitocondriale si functia celulara la varstnici, reviu

23 Teoria radicalilor liberi in procesul imbatranirii mitocondriale

24 Mitocondria decade in procesul imbatranirii datorita leziunilor oxidative

25 Citopatie mitocondriala la adulti: Ce stim de aceasta boala:

- Miopatiile mitocondriale sunt date de o anomalie a productiei de energie prin intermediul mitocondrilor.

Sa indentificat ca: Disfunctia mitocondriala fiind principala cauza legata de varsta in declinul bioenergetic

Medicii, oamenii de stiinta au: Selectat sinergic bioenergetice si aprobat de experti farmacologici care sa diminueze sau restaura complet multe aspecte ale functiei mitocondriale

Selectat sinergic bioenergetice si aprobat de experti farmacologici

- Combinatii de astfel de Suplimente nutritive care actioneaza pe mai multe obiective poate normaliza functia mitocondriala, creste pruductia de energie adenozintrifosfat ATP

26 Acetil L-Carnitina si Acid Alfa Lipoic un: Elixir al tineretii prin reducerea de stres oxidativ si a oxidarii ADN/ARN se incetineste procesul de inbatrinire la mitocondria care este uzina energetica de ATP

Acetil L-Carnitina reface nivelul de cardiolipina in membrana mitocondriala

27 Acetil L-Carnitina are capacitatea de a creste metabolismul energetic si ajuta la refacerea functiei mitocondriale

28 Acetil L-Carnitina amelioreaza reducera funtiei mitocondriale la varstnici

Carnitina acetiltransferaza are afinitate si activitate in cerebral prin Acetil L-Carnitina (ALC) + Acid Alfa Lipoic (AAL) efect Anti Aging

Acetil L-Carnitina si Acid Alfa Lipoi un: Elixir al tineretii

29 Acid Alfa Lipoic cofactor in producerea de energie in organizm, mitocondria uzina energetica decade pe masura inbatrinirii, adausul de Acetil L-Carnitina si Acidul Alfa Lipoic reduce stresul oxidativ si prelungeste tineretea, intirzie inbatrinirea Anti-Aging

Acid Alfa Lipoic ajuta la producerea de energie Adenozin-trifosfat (ATP) in organism prin oxidatia acidului piruvic si alfa-cetoglutaric in mitocondria - Acid dihidro lipoic (ADHL)

Acid Alfa Lipoic ajuta la producerea de energie Adenozin-trifosfat (ATP) in: Mitocondria uzina energetica a materiei vii, care decade cu varsta

30 Acid Alfa Lipoic creste functia mitocondriala, creste rata metabolica si scade leziunile oxidative de radicalii liberi

Acid Alfa Lipoic creste activitatea ambulatorie in calatorie

31 Concentratia serica de Carnitina in muschiul scheletal depinde de varsta si gen

32 L-Carnitina si Acid Alfa Lipoic cu eficacitate in ameliorarea declinului enzimelor mitocondriale in timpul inaintarii in varsta

33 L-Carnitina creste enzimele mitocondriele la muschiul scheletal al inimii

34 L-Carnitina cu rol la muschiul scheletal al inimii al varstnicilor se descreste activitatea in lantul respirator (lant transportor de electroni)

35 L-Carnitina cu rol la cardiomiopatia in copilarie indusa de disfunctia mitocondriala

36 L-Carnitina creste energia si vitalitatea organismului, are efect la metabolismul acizilor grasi prin transportul acizilor grasi catre mitocondrii unde este transformata in energie ATP, participa la reducerea lipidica hepatica si cresterea musculara cu reducerea greutatii corporale

L-Carnitina creste energia prin oxidarea moleculelor de acizi grasi, la nivelul mitocondriilor

37 L-Carnitina in disfunctia mitocondriala

38 Coenzima Q10 cu activitate in mitocondrii: Mitocondria uzina energetica a materiei vii, activeaza producerea de adenozintrifosfat (ATP)

39 Functia de Coenzima Q10 in mitocondria

40 Coenzima Q10 un update a functiei biochimice in mitocondria

41 Coenzima Q10 este omologul - Corespondentul la NADH Nicotinamida Adenin Dinucleotida restaureaza activitatea de NADH oxidaza a Complexului I

42 Coenzima Q10 cu valoare terapeutica mitocondriala indicat la tulburari bioenergetice

43 Coenzima Q10 un bioenergizant mitocondrial la mitocondria varstnicilor

44 Corelatia clinica si biochimica in miopatia mitocondriala tratata cu Coenzima Q10

45 Monitorizarea clinica in folosirea de Coenzima Q10 ca neurologic si la bolile musculare

46 Varsta, mitocondria si Coenzima Q10 o relatie neglijata

47 Coenzima Q10 imbunatateste metabolismul de piruvat deficitar si conductia de cardiac defect la sindromul Kearns-Sayre

48 Idebenone este un nootropic face parte din suplimentele nutritive Anti-Aging, este omologul - Corespondentul la Coenzima Q10

49 N-Acetilcisteina la fosforilarea oxidativa in declin la mitocondria, a muschiului pulmonar

51 N-Acetilcisteina cu efect de protectie la TNF alpha (tumor necrosis factor-alpha) care induce apoptoza la celulele U937: Rolul mitocondriei

52 N-Acetilcisteina cu protectie la declinul de fosforilarea oxidativa in mitocondria hepatica la varstnici

53 Tiamina (Vitamina B1) din MultiVitamineMinerale creste nivelul plasmatic de lactat si piruvat se foleseste in doza larga la pacienti cu sindrom Kearns-Sayre

- Tiamina (Vitamina B1) stimuleaza NADH care mareste fosforilarea oxidativa la Complex I - 100 mg de 3x/zi la Oftalmoplegia cronica progresiva sau boala Graefe

54 Rboflavina (Vitamina B2) cu succes in deficienta de NADH-CoQ reductaza la miopatie

Riboflavina (Vitamin B2) este un cofactor la Complex I si II la doza de 100 mg/zi creste capacitatea de exercitiu la pacienti cu miopatie mitocondriala indus de disfunctia Complexului I

55 Coenzyma Q10 si Niacinamida (Vitamina B3) din MultiVitamine energizant pentru mitocondria la varstnici si cu prelungirea vieti de 15% - Longevitate

56 Ulei de Peste - Omega-3 creste cardiolipina in membrana mitocondriala, previne descresterea de cardiolipina, cardioprotector si creste nivelul de Fosfatidilcolina previne

- Postulat: Teza teoretica generala care este recunoscuta ca justa fara demonstratie

60 Resveratrol in tratamentul de disfunctie mitocondriala sindromul melas, encefalopatie, acidoza lactica insotit de episoade de miopatie mitocondriala

Resveratrol activeaza Sirtuina care creste functia mitocondriala, creste rata metabolica si mimeaza efectul de restrictie calorica

61 Energizante Bio mitocondriale la varstnici

62 Prin Exercitiu fizic creste puterea, capacitatea respiratorie si rezistenta in exercitiu

Alte Tonice Energizante naturale cu efcte benefice pentru mitocondria: Creatina, Taurina, D-Riboza

63 Creatina suplimente creste performanta in volumul muscular, chimia clinica

64 Suplimente nutritionale cu Creatina creste masa musculara

Adenozin-difosfat (ADP) energia celulara scazuta, cu Adenozin-difosfat (ADP) + P = Adenozin-trifosfat (ATP) energie energia celulara inalta

65 Creatina Monohidrat creste performanta in exercitii la barbati si femei

66 Suplimentarea de Creatin influentiaza la performanta cu cicluri repetate la barbati

67 Creatina suplimente cu performanta la exercitiu: update Creatina este legala nu contravine la reglementarea actuala de dopaj: spune studiul

68 Suplimentarea de Creatina cu variabile de sanatate fara efecte adverse, studiu retrospectiv

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- Avantajul la: Trehaloza fata de alti carbohidrati nu poseda grupa reducatoare Carbonil pentru a forma reactia Maillard,

Pentru evitarea reactiei Maillard se recomanda consumul de: Trehaloza care nu formeaza produse a reactiei Maillard

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- Reactia Maillard este cunoscut favorizeza imbatranirea.

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Administrare recomandata de: United Mitochondrial Disease Foundation

Bibliografie-Referinte: Antioxidant Antioxidanti

Informatii din bibliografia electronica la tema: Nutritie si sanatate

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