TelomereSuport cu Astragaloside IV cu efect Anti-Aging

Enzima Telomeraza este cheia Longevitatii - Telomeraza elixirul tineretii

1 Astragaloside la activarea de telomeraza (Telomerase Activation) este singura terapie deosebit de promitatoare la reversia efectelor imbatranirii - Anti-Aging

2. Prelungirea de Telomere si activarea de Telomeraza

Astragalus (Astragalus membranaceus) Familia Fabaceae numita si a Leguminoaselor

Saponinele sunt glicozide triterpene cele din Astragalus numite si Astragaloside

Mai mult despre: Astragaloside

Mai mult despre: Telomeraza

Telomerase-Activation cu: Astragaloside IV 98% 50 mg + Chitosan 50 mg un potentiator de absobtiei la Astragaloside IV

Mai mult despre: Telomer (Telomere)

TelomereSupport

for Telomerase Activation

TelomereSuport = 1 Flacon a 90 buc cu 500mg/capsula

3 Astragaloside cu efect Anti-Aging, mecanism de actiune

Astragalus (Astragalus Membranaceus) exctract super Polizaharide 50,13%, Flavonoizi 7,47%, forma cea mai activa Astragaloside IV exctract standardizat 5,09%

4. Astragali Radix cu extractul standardizat de Astragaloside a avansat in medicina Anti-Aging, studii

Astragali Radix	TelomereSupport cu suplimente-nutritionale produse-naturale din medicina traditionala

Ce este Telomere?

Telomer (Telomere) sunt pentru ADN-ul purtator de material genetic, un suport care protejeaza cromozomii de degradare, mai mult despre: TelomereSuport.

- Telomerii umani sunt secvente necodate de ADN, situate la capatul cromozomilor, care sunt compuse din monomeri hexanucleotidici (TTAGGG)n, care se repeta de n ori.

- Telomeraza este o enzima care adauga secvente ADN specifice care se repeta ("TTAGGG") la sfirsitul catenei 3' a ADN-ului in Telomere, care sint localizati la capatul cromozomilor eucarioti.

Cromozom cu Telomere	Cromozom cu Telomere la capat	Ce este Telomeraza?

Ceasul biologic al organismului uman - Telomere servesc intrinsec ca ceas biologic

- Telomeraza consta in doua componente essentiale matrita ARN - RNA template (hTER) care actioneaza drept sediu pentru aditionarea de noi secvente telomerice, si o componenta catalitica - human Telomerase Reverse Transcriptase (hTERT) cu functia sintezei de Telomere unitati repetate in tandem pentru protectia integritatii cromozomilor si si prelungirea replicarii

5. Reconstituirea activitatii de Telomeraza in celulele umane duce la prelungirea Telomerilor continuarea replicarii

Beneficiul activarii Telomerazei

- Beneficiul activitatii telomerazei

- Telomeraza cu activitatea scazuta sau lipsa

- Telomere scurti deteriorati sta in legatura cu dauna celulelor si imbatranirea

- Telomerazei cu nivel ridicat de activitate

- Functia normala celulara

- Cromozomi sanatosi

- Genomul este stabil

- Continua sa prolifereze

- Extensia vietii celulare - Longevitate

Cine produce Telomeraza?

Telomeraza este produsa de genaTelomeraza (hTERT)	Gena Telomeraza hTERT cu actiune de Longevitate

Telomeraza este produsa de gena Telomeraza hTERT, localizata la cromozomul 5 introducerea de hTERT in cultura de fibroblasti umane a condus la prelungirea Telomerelor – Astragaloside IV (New Anti-Aging Therapy, “turns ON“ Your Longevity Gene)

Gena Telomeraza (hTERT) activeaza Telomeraza (Telomerase Activation), enzima Telomeraza ajuta ADN polimeraza la aditionarea de moi secvente Telomerice pe matrita ARN

- Procesul: Telomerelor care se scurteaza odata cu varsta

- Replicarea catenei intarziate de un cromozom liniar intampina o problema pe catena 3'

- Daca deplasarea si polimerizarea porneste de pe catena 3' in directia 5' polimerizarea se realizeaza discontinu

- Pe cele 2 catene matrita are loc sinteza sub actiunea ADN polimerazei a si d

- Sinteza sub actiunea ADN polimerazei la catena avansata este completata

- O lipsa la catena intarziata 3' are ca rezultat scurtarea Telomerelor dupa fiecare diviziune celulara si replicare a ADN-ului.

- Eventuale informatii importante se pierd, iar noile celule nu sint viabile

- Activarea Telomerazei - Telomeraza contine:

a. O molecula de ARN folosita ca matrita

b. Revers transcriptaza face ADN-copii pe matrita de ARN

- Telomerele sunt formate din elemente repetitive (la om TTAGGG) dispuse in tandem - Prin activarea Telomerazei se pot aduga perechi de baze

- Acest lucru lasa in urma un tandem de sase baze care se repeta numite Telomere

- Sinteza procesului este completat de catena intarziata

- Genomul este protejat de posibilitatea de a pierde informatii

Nobelul pentru fiziologie si medicina pe 2009: Cum cromozomii sint protejati de Telomere si enzima Telomeraza - The 2009 Nobel Prize in Physiology or Medicine: how chromosomes are protected by telomeres and the enzyme telomerase

Scopul stiintei este de a ajuta la: Incetinirea procesului de imbatranire prin activarea Telomerazei

Telomeraza si senescenta

Telomele scurtate da un semnal celulelor la oprirea diviziunii celulare - Senescenta

Reconstituirea pielii prin telomerizare

Pielea mana reconstituita de Telomeraza

Celulele pielii imbatranite tratate cu Telomeraza, pielea devine tinara

6. Reveratrol intirzie efectul senescentei prin activitatea de Telomeraza via PI3K

7. Radacina de astragal cu cei doi izomeri 4-hydroxy-5-hydroxymethyl-[1,3]dioxolan-2,6'-spirane-5',6',7',8'-tetrahydro-indolizine-3'-carbaldehyde (HDTIC), HDTIC-1, HDTIC-2 si L-Carnosine intirzie senescenta la celule umane diploide tip fibroblast

8 L-Carnosina reduce dauna de telomere cu rata de scurtare a telomerelor in cultura de fibroblast

Terapia Anti-Aging cu Carnosina	Carnosina cu actiune de longevitate (Life Extension)

9. Extractul de Gingko Biloba reduce senescenta celulor endoteliale progenitoare augmentata prin activitatea de Telomeraza

Gingko Biloba reduce senescenta	- Vitaminele adauga vitalitate la cromozomii imbatraniti

10 MuliVitamineMinerale cu efect de prelungirea telomerelor la femei

Alte suplimente nutritive cu suport dietar la Telomere:

- MuliVitamineMinerale cu continut de Vitamina B -uri 25mg/capsula pentru mentinera nivelului scazut de homocisteina, Vitamina E 100 U.I., Vitamina D 200 U.I. sau:

- Homocisteina Formula

- Vitamina C

- Vitamina E 400 U.I.

- Vitamina D 1000 U.I.

11. Luingimea de Telomere in celulele mononucleare periferice este asociat cu statusul de Acid Folic la barbati

12. Tratamentul de hiperhomocisteinemia baza fiziologica cu Tiamina Riboflavina Niacina, Vitamina B6, Acid Folic, Vitamina B12, Biotina si Colina

13 Cresterea nivelului de homocisteina este asociat cu scurtarea lungimii Telomerelor de leucocite - Homocisteina Formula previne cresterea nivelului de homocisteina.

14 Concentratia serica inalta de Vitamina D este asociat cu lungimea de telomere la femei

Vitamina D	Vitamina E

15 Vitamina E (Alfa-tocoferol), un alt antioxidant cunoscut, a fost demonstrat, ca inpiedica scurtarea telomerilor si mentinerea in activitate telomeraza endoteliului microvascular cerebral

16. N-Acetilcisteina si antioxidantii intirzie senescenta, contracarind cresterea de ROS care induc imbatranirea celulelor endoteliale

17. N-Acetilcisteina un precursor de Glutationa previn stresul cronic care compromite integritatea Telomerilor si accelereaza debutul senescentei in celulele endoteliale umane

18 Imbatranirii dependenta de scurtarea Telomerelor este executata in keratinocitele din pielea umana de hormesis urmelor de peroxidul de hidrogen sau prin Vitamina C sau pro-Vitamina C care reduce stresul intracelular

19 Imbatranirii dependenta de scurtarea Telomerelor este reprimata de Vitamina E impreuna cu longevitatea celulara si intracelulare de reducere a stresului oxidativ in creierul uman

20 Scurtarea de Telomere este asociata cu disfunctia mitocondriala, imbunatatirea functiei mitocondriale are ca rezultat reducerea scurtarii Telomerilor, Telomeraza are functie de prelungire a Telomerelor scurtate si protectie de stresul oxidativ

Energizante Naturale cu: N-Acetilcisteina, Acetil L-Carnitina, Acid Alfa Lipoic, Coenzima Q10, previne in mitocondria disfunctia mitocondriala iar ca rezultat reducerea scurtarii Telomerilor

Telomere Suport confera Longevitate cu: Suport dietar la Telomere

Radacina de Astragalus membranaceus cu continut de flavonoizi, izoflavonoizi, saponine, polizaharide, aminoacizi si cei doi izomeri HDTIC-1 si HDTIC-2 care nu mentine fenotipul de senescenta

21 Compusi de izomeri HDTIC-1 si HDTIC-2 din radacina de astragal (Astragali Radix) incetinesc rata de scurtare a Telomerelor via atenuarii stresului oxidativ si abilitatii de crestere a reparatiei ADN-ului la celule umane diploide tip fibroblast in plamini

22. Telomeraza umana extinde durata de viata in fibroblasti

23. Radacina de Astragalus membranceus cu cei doi izomeri HDTIC-1 si HDTIC-2 cu efect anticancer inactiveaza expresia genei p16 in celulele 2BS

24 Lungimea telomerilor promite supravietuire independent de influente genetice

25. Activitatea de Telomeraza este mentinuta pe toata durata de viata la pasarile cu viata lunga

26 Lungimea telomerilor se mosteneste de la parinti si este asociata cu durata de viata pentru cresterea copilului

27 Mecanismul imbatranirii: Rolul Telomerelor care se scurteaza odata cu varsta

28 Scurtarea Telomerelor si imbatranirea

Bolile induse datorita scurtarii Telomerelor

29 Scurtarea Telomerelor in ficat

Cum si de ce imbatranim - Ph.D Leonard Hayflick - How and why we Age

- Capacitatea limitata de replicare Hayflick
- In timpul fiecarei diviziuni celulare, se pierde secvente din ADN-ul telomeric la fiecare faza replicativa, pina cind ajunge la o faza critica cind diviziunea celulara se opreste, intra in faza 2 si trec prin senescenta.
- Senescenta este fenomenul cind celulele diploide nu are abilitatea de a se divide si rezulta ruperea celor doua catene, fenomen numit senescenta replicativa, fenomenul Hayflick.

Hayflick: Cele trei faze celulare	- Celulele umane diploide

30 Scurtarea Telomerelor in pancreas

31. Timpul limitatat de viata a celulelor diploide umane

32 Scurtarea Telomerelor la glanda tiroida si paratiroida

33 Componenta telomerazei este defecta in boala diskeratoza congenitala

34 Diskeratoza congenitala o boala a disfunctiei de Telomere

35 Prelungirea vietii - Longevitate prin introducerea de telomeraza in celula umana

36. Metode pentru cresterea telomerazei - Patentat de Geron

37. Foliculul de par farmacodinamica, compozitie pentru activitatea de Telomeraza - Patentat de Geron

Stiinta ingrijirii parului

38 Imbatranirea pielii: Rolul Telomerazei - Dinamica Telomerelor

Dinamica Telomerelor inainte de activarea Telomerazei si dupa activare, cu extensia Telomerelor

Enzima Telomeraza este responsabila pentru mentinerea lungimii Telomerelor si functia cromozomilor

- Sfirsitul replicatiei daca nu se intervine cu: Telomeraza care activeaza reintinerirea celulara

39 Activitatea de Telomeraza si lungimea de Telomere poate direct afecta abilitatea de regenerare a tesuturilor, scurtarea de telomere induce disfunctia celulelor stem

40 Biologia telomerelor si bolile cardiovasculare

41 Telomere si imbatranirea biologica la bolile cardiovasculare

42. Uzura Telomerelor din globule albe corelate cu leziuni cardiovasculare

43. Lungimea de Telomere scade o data cu varsta in celulele endoteliale, contribuie la disfunctia endoteliala si atheroscleroza

44. Lungimea de Telomerelor de leucocite si bolile cardiovasculare

45. Disfunctia telomerelor la hipertensiune

46. Imbatranirea celulara in relatie cu stresul si factorii de risc in bolile cardiovasculare

47. Scurtarea telomerilor este accelerata, ca raspuns la viata de stres

48. Telomerele si non Telomere daune ale ADN- ului sunt factori determinanti in senescenta celulara la mamifere

49. Asociere intre activitatea fizica in timpul liber si lungimea Telomerelor de leucocite

50. Telomeraza bazata pe cresterea farmacologica in sistemul imunitar cu functia antivirala a limfocitelor CD8

51. Astragaloside IV cu efect la sistemul imunitar pacientiilor cu insuficienta cardiaca congestiva

52. Activitatea de Telomeraza este indusa prin receptorul de antigen al limfocitelor B

53. Impactul menopauzei la lungimea Telomerelor de leucocite si relatia sa cu rezistenta la insulina si inflamatii

54. Astragaloside IV cu activitate antiinflamatorie, mediata de inhibarea de NF-kappaB

55. Reducerea Telomerelor de leucocite in osteoartrita

Catabolismul cartilajului la osteoartrita

56. Scurtarea lungimii Telomerelor de leucocite este independent asociat cu o scaderea densitatii minerale osoase si prezenta de osteoporoza la femei - Lungimea de Telomere poate fi un marker al varstei biologice osoase

Osteoporoza

57. Lungimea de Telomere este un marker al varstei biologice.

58. Terapia Telomerazei la bolile degenerative

59. Acelerarea eroziunii de Telomere este asociata cu declinul functiei imunitare la boala Alzheimer

Boala Alzheimer

60. Introducerea de TERT enzima telomeraza-revers transcriptaza in fibroblaste creste capacitatea de reparatie a ADN-ului

61. Telomeraza nu este oncogena

62. Scurtarea Telomerelor este suficienta a cauza defecte degenerative

63. Factorii de mediu asociate cu mentinerea lungimii telomerelor la varstnici gemeni de sex masculin

64. Stabilirea de Astragaloside IV din radacina de Astragal

65. Farmacocinetica la Astragaloside IV este favorabila

66. Transportul si biodisponibilitatea la Astragaloside IV un ingredient activ din radacina de Astragal

67. Chitosan un potentiator al absobtiei la Astragaloside IV, mecanism de transport

68 Astragaloside IV parte distincta din Astragalus membranaceus in restaurarea imunitara la pacienti de cancer si reversia indusa de ciclofosfamida

69 Astragaloside IV parte distincta din Astragalus membranaceus in imunoterapie si reversia indusa de ciclofosfamida un suppressor sistemului imunitar

70 Extractul din Astragalus membranaceus cu raspuns imunitar dependent de continutul de polizaharide

71. Astragalus standardizat Polizaharide (APS) cu raspuns imunitar

72 Extractul din Astragalus membranaceus este un modulator imunitar

73 Extractul din Astragalus membranaceus un potetiator de lymphocyte-activated killer (LAK) cell

74. Astragaloside IV cu efect la proliferarea de limfocite B, T si cu functie de macrofage peritoneale

75 Astragaloside IV cu efect antiviral la virusul Coxsackie B3

76 Astragaloside IV cu efect antiviral la virusul Coxsackie B3 regleaza interferonul gama

77 Extractul din Astragalus membranaceus cu efect de imbunatatirea memoriei

78. Astragaloside cu rol in regenerarea sistemului nervos periferic

79 Astragaloside IV protejeaza de accidentele vasculare cerebrale hemoragice si ischemice

80 Astragaloside IV inhiba proliferarea, promoveaza apoptoza si impiedica procesul patologic vasculare la pacientii diabetici.

81. Astragaloside IV cu efect de neuroprotectie

82 Astragalus membranaceus Bge. saponine - Astragaloside IV cu efect inotropic, posibil mecanism

83 Astragaloside cu efect de rezistenta la radiatia celulelor de maduva osoasa sau de celule aflate in sangele periferic

84 Cardioprotectia indusa de Astragaloside IV de la Astragalus membranaceus in timpul ischemiei miocardice

85 Astragaloside IV la tratarea de daunele miocardice

86 Astragaloside IV cu efect in functia cardiaca

87. Astragaloside cu efect in functia cardiaca la ischemia miocardica

88. Astragaloside IV cu efect la insuficienta cardiaca

89. Astragaloside IV cu doza mare poate suprima apoptoza miocardica indusa de Adriamicina cu mecanism posibil legat de expresia BCL-2 si BAX

90 Astragaloside IV cu efect benefic la hipoxie si reoxigenarea de cardiomiocite via reticulul sarcoplasmatic Ca-ATP-aza

91. Astragaloside IV reface vatamarea acuta miocardica indusa de isoproterenol, prin prevenirea schimbarilor SERCA2a si expresia proteinei fosfolamban

92. Astragaloside IV cu efect inbunatateste functia cardiaca si joacă un rol important la reducerea excesiva de Ca intracelular in interiorul celulelor miocardice

93. Astragaloside IV cu actiune vasodilatoare, mecanism de actiune a dilatatiei dependente de endoteliu via NO-cGMP

Metabolismul oxidului nitric NO determina relaxarea prin stimularea de guanilat ciclaza si in consecinta productia de guanozin monofosfat ciclic cGMP

94. Oxidul nitric NO activeaza Telomeraza si intarzie senescenta celulelor endoteliale

Temperatura corporala normala si protejarea extremitatilor impotriva frigului este foarte importanta.

Frigul produce o vasoconstrictie rezultatul fiind ingustarea progresiva a lumenului vascular cu reducerea fluxului sanguin in special la membrele inferioare, medicul va prescrie un vasodilator un medicament care creste calibrul vaselor mici si imbunatateste circulatia.

Tratamentul cu vasodilatori:

Studiu vasodilator cu vasodilatatoarele Astragaloside IV, Gingko Biloba, Carnosina si Omega-3-Ulei de Peste sau Vitamina E care creste fluiditatea singelui.

95. Astragaloside IV cu actiune vasodilatoare la vasele normale si spontane hipertensive

96. Astragaloside IV la inflamatii si hipertensiune

97. Astragaloside IV cu efect la patogeneza sindromului metabolic

98. Astragaloside IV cu efect la insuficienta renala acuta ischemica

99. Disfunctia renala este asociat cu scurtarea lungimii telomerelor la insuficienta cardiaca congestiva

100. Astragaloside IV cu efect venotonic

101. Astragaloside IV cu protectie la celulele endoteliale indusa de nivelul crescut de glucoza

102. Astragaloside IV cu efect la sindromul metabolic

103. Astragaloside IV cu efect la boala ischemica renala

104. Astragaloside IV cu efect de gastroprotectie

105. Astragalus (Astragalus membranaceus) si Gingko Biloba la inversarea chimica indusa de fibroza hepatica

106. Astragalus (Astragalus membranaceus) si Gingko Biloba folosit cu succes la fibroza hepatica si ciroza

107. Astragaloside IV izolat din Astragalus (Astragalus membranaceus) cu activitate de anti virala a hepatitei B

108. Astragaloside cu efect antinociceptiv mecanism de actiune

TelomereSuport - Instructiuni de administrare - 1100 perechi de baze - Reversia de 22 de ani eroziune telomerica - Rezultatul de la laboratorul Repeatdiagnostics

109. Masurarea lungimii Telomerelor

Bibliografie - References - Referinte: Astragaloside

Informatii din bibliografia electronica la tema: Nutritie si sanatate

1 "Telomerase Activation is the single most promising approach to reversing the effects of aging," said Michael Fossel, MD, PhD.
2 Weng NP, Granger L, Hodes RJ. Telomere lengthening and telomerase activation during human B cell differentiation. Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10827-32.
3. Lei H, Wang B, Li WP, Yang Y, Zhou AW, Chen MZ. Anti-aging effect of astragalosides and its mechanism of action. Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China. Acta Pharmacol Sin. 2003 Mar;24(3):230-4.
4. Chen K, Li C. Recent advances in studies on traditional Chinese anti-aging materia medica. Institute of Geriatrics, Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing. J Tradit Chin Med. 1993 Sep;13(3):223-6,
5. Vaziri H, Benchimol S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada. Curr Biol. 1998 Feb 26;8(5):279-82.
6. Xia L, Wang XX, Hu XS, Guo XG, Shang YP, Chen HJ, Zeng CL, Zhang FR, Chen JZ. Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms. Department of Cardiovascular Diseases, the First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, PR China. Br J Pharmacol. 2008 Oct;155(3):387-94. Epub 2008 Jun 30.
7. Wang P, Zhang Z, Ma X, Huang Y, Liu X, Tu P, Tong T. HDTIC-1 and HDTIC-2, two compounds extracted from Astragali Radix, delay replicative senescence of human diploid fibroblasts. Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing 100083, PR China. Mech Ageing Dev. 2003 Dec;124(10-12):1025-34.
8 Shao L, Li QH, Tan Z. L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts.Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, PR China. Biochem Biophys Res Commun. 2004 Nov 12;324(2):931-6.
9. Dong XX, Hui ZJ, Xiang WX, Rong ZF, Jian S, Zhu CJ. Ginkgo biloba extract reduces endothelial progenitor-cell senescence through augmentation of telomerase activity. Department of Cardiology, the First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, China. J Cardiovasc Pharmacol. 2007 Feb;49(2):111-5.
10 Xu Q, Parks CG, Deroo LA, Cawthon RM, Sandler DP, Chen H. Multivitamin use and telomere length in women. Am J Clin Nutr. 2009 Mar 11
11. Paul L, Cattaneo M, D'Angelo A, Sampietro F, Fermo I, Razzari C, Fontana G, Eugene N, Jacques PF, Selhub J. Telomere length in peripheral blood mononuclear cells is associated with folate status in men. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA. J Nutr. 2009 Jul;139(7):1273-8. Epub 2009 May 20.
12. Kang SS. Treatment of hyperhomocyst(e)inemia: physiological basis. Department of Pediatrics, Section of Genetics, Rush Medical College and Rush-Presbyterian St. Luke's Medical Center, Chicago, IL 60612, USA. J Nutr. 1996 Apr;126(4 Suppl):1273S-5S.
- Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. National Academy Press. Washington, DC, 1998.
13 Richards JB, Valdes AM, Gardner JP, Kato BS, Siva A, Kimura M, Lu X, Brown MJ, Aviv A, Spector TD. Homocysteine levels and leukocyte telomere length. Centre for Twin Research and Genetic Epidemiology Unit, St Thomas' Hospital, King's College London School of Medicine, London, UK. Atherosclerosis. 2008 Oct;200(2):271-7. Epub 2008 Feb 15.
14 Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Twin Research and Genetic Epidemiology, St Thomas' Hospital, King's College, London School of Medicine, London, United Kingdom. Am J Clin Nutr. 2007 Nov;86(5):1420-5.
15 Y. Tanaka, Y. Moritoh, N. Miva, Age-dependent telomere-shortening is repressed by phosphorylated a-tocopherol together with cellular longevity and intracellular oxidative-stress reduction in human brain microvascular endotheliocytes. J. Cell. Biol., in press.
16. Haendeler J, Hoffmann J, Diehl JF, Vasa M, Spyridopoulos I, Zeiher AM, Dimmeler S. Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany. Circ Res. 2004 Apr 2;94(6):768-75. Epub 2004 Feb 12.
17. Kurz DJ, Decary S, Hong Y, Trivier E, Akhmedov A, Erusalimsky JD. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. Department of Medicine, University College London, 5 University Street, London, WC1E 6JF, UK. J Cell Sci. 2004 May 1;117(Pt 11):2417-26.
18 Yokoo S, Furumoto K, Hiyama E, Miwa N. Slow-down of age-dependent telomere shortening is executed in human skin keratinocytes by hormesis-like-effects of trace hydrogen peroxide or by anti-oxidative effects of pro-vitamin C in common concurrently with reduction of intracellular oxidative stress. Laboratory of Cell Death Control BioTechnology, Hiroshima Prefectural University School of BioSciences, Shobara, Hiroshima 727-0023, Japan. J Cell Biochem. 2004 Oct 15;93(3):588-97.
19 Tanaka Y, Moritoh Y, Miwa N. Age-dependent telomere-shortening is repressed by phosphorylated alpha-tocopherol together with cellular longevity and intracellular oxidative-stress reduction in human brain microvascular endotheliocytes. Laboratory of Cell-Death Control BioTechnology, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Nanatsuka, Shobara, Hiroshima 727-0023, Japan. J Cell Biochem. 2007 Oct 15;102(3):689-703.
20 Passos JF, Saretzki G, von Zglinicki T. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection. Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, UK. Nucleic Acids Res. 2007;35(22):7505-13. Epub 2007 Nov 5.
21 Wang P, Zhang Z, Sun Y, Liu X, Tong T. The Two Isomers of HDTIC Compounds from Astragali Radix Slow Down Telomere Shortening Rate via Attenuating Oxidative Stress and Increasing DNA Repair Ability in Human Fetal Lung Diploid Fibroblast Cells. Aging Research Center, Health and Science School of Peking University , Beijing, People's Republic of China . DNA Cell Biol. 2009 Oct 19.
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