Celule-Stem Nutra-Stem^®

Nutra Stem^® un stimulator de celule-stem adulte

Refacerea hematopoiezei cu Nutra-Stem^®

2 Nutra-Stem^® sint: Nutraceutice Anti-Aging sinergetice, promoveaza proliferarea celulelor stem ale organismului uman, reduce apoptoza neuronala

3 Radicalii liberi reduc viata celulelor stem hematopoetice

4 Neurodegenerarea indusa de insuficienta mitocondriala: Celulele stem la refacerea cerebrala folosind managementul integrativ

Nutrienti trofici ca Acetil L-Carnitina, Alfa Glicerofosforilcolina, Ulei de Peste Omega 3 EPA/DHA se combina cu Alfa Glicerofosforilcolina formind membrana celulelor nervoase

Nutrienti ortomoleculari pentru vitalitatea si prelungirea vietii: Acid Alfa Lipoic, Coenzima Q10, Vitamine din grupa B, Vitamna E, Vitamina K.

Refacerea celulelor stem: In mod natural maduva osoasa elibereaza celule stem care calatoresc prin fluxul sangvin catre celulele care au nevoie.

Celule stem sint directionate sa se diferentieze in tipul celulei ale acestui organ

Diferentierea in diferite tipuri de celule

Maduva osoasa adulta contine celule stem mezenchimale care poate genera o mare varietate de tesuturi, precum os, tendon, cartilaj, muschi si chiar neuroni.

5 Resveratrol la diferentierea celulelor stem neuronale

6 Resveratrol creste proliferarea si diferentierea osteoblastica la celulele stem mezenchimale umane via activarea ERK1/2

7 Resveratrol inhiba NF-kappaB cu protectie a celulelor stem mezenchimale derivate din cultura de condrocite la CGS cu efect de inhibare a interleukina 1 beta, acest efect este mediata de integrine 1 beta

8 Resveratrol creste celule dermale: keratinocite, previne reduce inflamatia UVA care induce dauna ADN

9 Colagenul tip IV cu rol important in legarea keratinocitelor dermale de celule stem la jonctionea dermo-epidermica (dermal-epidermal junction - DEJ)

10 Fucoidan extract in tratamentul uman de ingrijire a pielii cu activitate Anti-Aging si necesar in cosmetica

11 Fucoidan moduleaza procesul de vindecare a ranilor prin TGF-b1 (Transforming Growth Factor) care sunt responsabile de activarea fibroblastelor si de sinteza, secretia si depunerea matricei extracelulare de colagen si proteoglican

12 Ceai Verde cu extr. stand. EGCG un polifenol natural pentru ingrijirea pielii, reda tonusul si elasticitatea pierduta prin inhibarea de colagenaza - Anti Aging Skin Care ^®

13 Ceai verde cu efect la acumularea cu varsta reactiilor Maillard cu grupa carbonil in aorta si colagenul pielii

14 Carnosina cu raspuns la carcinomul embrionar (teratocarcinom) si la diferentierea de celule stem

15 Carnosina cu rol de mentinerea sanatatii celulare

16 Carnosina: Enigma sa exemplificat prin actiunea Anti-Aging un antioxidant anti glicozilare, cu abilitate de influenta metabolismul alterat al polipeptizilor cu reparatia proteinelor alterate, participa in reparatia grupa aspartil a proteinelor, cu proprietati de chelare a ionilor toxici a metalelor, anti-convulsant, un inhibitor la senescenta fibroblastelor, un inhibitor de fosforilare, in initierea translatiei factorului eIF4E, in mutatii la nivelul genei care influentea prelungirea vietii - Longevitate

Terapia Anti-Aging cu Carnosina	Carnosina cu actiune de Longevitate (Life Extension)

17 L-Carnosina reduce dauna de telomere cu rata de scurtare a telomerelor in cultura de fibroblast

Telomere se scurteza cu diviziunea celulara

Cromozom cu secvente de telomere la capat	Carnosina reduce rata de scurtare telomerelor

18 Vitamina D stimuleaza diferentierea osteoblastica la celulele stem mezenchimale umane in fractura

19 Activitate de aromataza a celulelor stem mezenchimale umane este stimulata de diferentiere si de Vitamina D

20 Receptorul de Vitamina D (VDR) este esential pentru functia normala a celulelor stem keratinocite

21 Ulei de Peste mediaza la celulele stem din maduva osoasa care genereaza celule progenitoare.

22 Ulei de Peste cu impact hematopeietic la refacerea hematopoiezei prin reducerea celulelelor progenitoare mieloide din maduva osoasa.

23Fucoidan stimuleaza celulele stem prin inhibarea unei proteine numite E-selectin

24Fucoidan (Laminaria japonica) cu continut in sulfati (SO4) polizaharide sint involvate in mobilizarea de celule progenitoare/stem si cresterea nivelului de SDF-1

Cresterea numarului celulelor stem adulte in circulatie

25 Fucoidan (Laminaria japonica) cu efect de a genera celule endoteliale progenitoare (din celulele stem)

Fucoidan cu continut de: Laminarina, sulfati, carbohidrati, l-fucoza, d-xyloza, d-galactoza, d-manoza, d-glucuronic, acid fucoidan, acid alginic, alginate, mucopolizaharide, vitamina A, B, C, D, E, inositol, biotina, acid folic, minerale colidale, calciu, zinc, bor, seleniu, 80 oligoelemente, polifenoli, flavonoizi, steroli din plante, proteine esntiale si neesentiale, crotenoizi, luteina, zeaxantina, xantofile, lipide, alfa lipoice, omega -3, omega -6, glucosaminoglicani, enzime, adn/arn, regulatori celulari, etc.

26 Fucoidan cu continut in sulfati (SO4) polizaharide la expressia de celule stromale factor -1 si receptorul CXR4 regenereaza ficatul

27 Consumul de Fucoidan creste expresia de CXCR4 si a celulelor umane de CD34+

28 Fucoidan cu activitate imunomodulatoare

29 Fucoidan cu capacitate imunomodulatoare, poate fi folosit ca vaccin DC in imunoterapie

30 Fucoidan cu proprietati antivirale

31 Fucoidan cu efect la invectia virusului herpes simplex

32 Noul antiviral Fucoidan

33 Studiu de evaluare a produsului natural Fucoidan cu efect antivirale si aplicatia sa la virusul de influenza A

34 Fucoidan cu continut in sulfati (SO4) polizaharide cu actiune anti-mutagenica

35 Fucoidan u continut in sulfati (SO4) polizaharide inhiba proliferarea celulara

36 Fucoidan previne cancerul mamar

37 Fucoidan previne carcinogeneza mamara

38 Fucoidan (extract din laminaria japonica) o alga marina polizaharida cu proprietati imunologica si activitate anti tumorala

39 Fucoidan activitate anti tumorala si raspuns imunitar

40 Fucoidan u continut in sulfati (SO4) polizaharide inhiba activitatea de hialuronidaza cu rol in infectii si metastaza tumorala

41 Fucoidan o alga marina polizaharida cu proprietati imunologica si activitate anti tumorala

42 Fucoidan cu efect antitumoral la linia celulara a cancerului bronhopulmonar

43 Fucoidan o alga marina cu sulfati (SO4) polizaharide cu activitate antitumorala anti metastaza

44 Fucoidan induce apoptoza la celulele infectate de leucemie

45 Fucoidan extract induce apoptoza celulelelor infectate de leucemie de tip1 si celulele adultede leucemie (ALT)

46 Fucoidan cu efect la carcinomul hepatocelular

47 Fucoidan o alga marina brun polizaharida cu sensibilitate la celulele maligne limfoide

48 Fucoidan cu sulfati (SO4) polizaharide inhiba celulele virusul T- limfotropic uman tip-1

49 Fucoidan cu efect anticancer induce apoptoza la celulele HS-sultan acompaniat cu activitatea de caspaza-3 si scaderea de ERK

50 Fucoidan cu efect de inhibare la adeziunea celulelor de adenocarcinom pe fibronectina

51 Fucoidan cu actiune anticacinogenica si efect chemopreventiv

52 Fucoidan cu efect de radioprotectiv supravietuirii celulelor de la maduva spinarii si imunoreactie

53 Fucoidan cu efect de radioprotectiv dupa o iradiere totala

54 Fucoidan cu activitate antibacteriala si imunomodulatoare

55 Fucoidan cu efect de preventie la infectia bacteriana de Helicobacter pylori

56 Fucoidan cu efect de inhibare a adeziunii bacteriei Helicobacter pylori

57 Fucoidan alga marina polizaharida cu activitate biologica si efect anti-ulcer

58 Fucoidan cu proprietati de protectie a mucoasei gastrice

59 Continut inalt de sulfati Fucoidan poseda activitate anticoagulanta, antitrombotica

60 Fucoidan cu efect antitrombotic superior fata de heparina la tromboza

61 Folosirea de Fucoidan cu continut inalt de sulfati este un anticoagulant, antitrombotic cu perspective de viitor

62 Fucoidan din alga bruna cu activitate anticoagulanta

63 Fucoidan din alga bruna cu activitate de imunostimulare si anticoagulanta

64 Fucoidan cu activitate antiinflamatoare, anticoagulanta, antiangiogenica si antiadeziva

65 Fucoidan inhiba productia de anticorpii IgE care sunt implicati in reactii alergice

66 Fucoidan cu actiune de chelare a isotopilor radioactivi ca cesiu, zirconiu, ruteniu

67 Fucoidan cu continut de alginat la chelarea metalelor grele

68 Fucoidan (extract din laminaria japonica) inhiba inflamatia de meningita

69 Fucoidan cu efect in tratamentul de colagenaza care induce hemaoragie intracerebrala

70 Fucoidan cu efect profilactic la infectia cu prioni

71 Fucoidan un inhibitor de colinesteraza important la preventia bolii Alzheimer

72 Terapia anti-selectina previne dauna intestinala si leziunile ischemice hepatice

73 Fucoidan (extract din laminaria japonica) inhiba proteina C-reactiva

74 Fucoidan promoveaza revascularizarea cardiovasculara

75 Fucoidan cu efect profilactic la dauna renala indusa de hiperoxaluria (nivel ridicat de oxalati in urina)

76 Analiza urinei (caracterele fizice si chimice ale urinei) poate fi restabilita cu administrarea de Fucoidan

77 Ceai Verde un produs natural fotoprotector protejaza pielea de radiatiile UV, cu activitate antioxdanta si imunomodulatoare

EGCG un produs natural fotoprotector protejaza pielea

78 Ceai Verde EGCG - Galatul de epigalocatechina prelungeste viata (Prolongation of life span) Anti-Aging previne accidentul vascular cerebral

79 Suplimente nutritive de Ceai Verde, Carnosina, Vitamina D3 cu efect de neuro protectie la accidentul vascular cerebral

80 Ceai Verde cu EGCG cu specific anti-cancer

81 Ceai Verde cu EGCG mediaza inhibarea de T celulare NF-kapa B si exercita neuroprotectie in encefalomielita autoimuna

82 Ceai Verde cu EGCG cu efect la schimbarea nivelului de poliamina si dauna neuronala dupa ischemie cerebrala tranzitorie

83 Ceai Verde cu EGCG cu efec de neuroprotectie dupa toxicitatea factorului amiloid-beta

84 Suplimente cu Antocianidine 25% cu neuroprotectie reface declinul in hipocamp HSP70

85 Suplimente cu Antocianidine 25% reface declinul in transmiterea signalelor neuronale, functia cognitiv si deficitul motoric

86 Suplimente cu Antocianidine 25% moduleaza functia cognitiva in hipocamp

87 Suplimente cu Antocianidine 25% si Spirulina reduce dauna ischemica cerebrala

88 Suplimente cu Antocianidine 25% si Spirulina creste si reface dopamina

89 Afine (Vaccinium Myrtillus) extr.stand. (Antocianidine) 25% cu activitate anticancer

90 Afine (Vaccinium Myrtillus) extr.stand. (Antocianidine) 25% un vasodilator indicat pentru fluiditatea singelui

91 Afine (Vaccinium Myrtillus) extr.stand. (Antocianidine) 25% la microcirculatia in ischemia acuta miocardica

92 Extracte de Antocianidine cu proprietati vasoactive, vaso protectoare

93 Extracte de Antocianidine cu efect la vasodilatatia musculara si permeabilitatea capilarelor, indicat pentru diabetici

94 Afine (Vaccinium Myrtillus) extr.stand. (Antocianidine) 25% noul antioxidant in sanatatea umana si preventia bolilor

95 Afine (Vaccinium Myrtillus) extr.stand. (Antocianidine) 25% indicat la retinopatie diabetica, studiu randomizat dublu orb placebo controlat

96 Afine (Vaccinium Myrtillus) extr.stand. (Antocianidine) 25% mareste acuitatea vizuala noaptea si cu sensibilitate la contrast

97 Afine (Vaccinium Myrtillus) extr.stand. (Antocianidine) 25% previne degenerescenta maculara si cataracta

98 Afine (Vaccinium Myrtillus) extr.stand. (Antocianidine) 25% la disconfort digestiv - dispepsie pentru copii

Bibliografie-Referinte: Nutra-Stem - Celule-Stem

Informatii din bibliografia electronica la tema: Nutritie si sanatate

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2 Bickford PC, Tan J, Shytle RD, Sanberg CD, El-Badri N, Sanberg PR. Nutraceuticals synergistically promote proliferation of human stem cells. Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA. Stem Cells Dev. 2006 Feb;15(1):118-23.
3 Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y, Suda T. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med 2006;12:446–451.
4 Kidd PM. Neurodegeneration from mitochondrial insufficiency: nutrients, stem cells, growth factors, and prospects for brain rebuilding using integrative management. University of California, Berkeley, USA. Altern Med Rev. 2005 Dec;10(4):268-93.
5 Hauss F, Liu J, Michelucci A, Coowar D, Morga E, Heuschling P, Luu B. Dual bioactivity of resveratrol fatty alcohols: differentiation of neural stem cells and modulation of neuroinflammation. Laboratoire de Chimie Organique des Substances Naturelles, UMR 7177 CNRS, Université Louis Pasteur, 67084 Strasbourg Cedex, France. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4218-22. Epub 2007 May 17.
6 Dai Z, Li Y, Quarles LD, Song T, Pan W, Zhou H, Xiao Z. Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation. Institute of Clinical Pharmacology, Central South University, Changsha 410078, China. Phytomedicine. 2007 Dec;14(12):806-14. Epub 2007 Aug 8.
7 Authors: LEI, Ming1; LIU, Shi-qing; LIU, Yu-lan2 Resveratrol protects bone marrow mesenchymal stem cell derived chondrocytes cultured on chitosan-gelatin scaffolds from the inhibitory effect of interleukin-1β. Acta Pharmacologica Sinica, Volume 29, Number 11, November 2008.
8 Seve M, Chimienti F, Devergnas S, Aouffen M, Douki T, Chantegrel J, Cadet J, Favier A. Resveratrol enhances UVA-induced DNA damage in HaCaT human keratinocytes. Laboratoire des Lésions des Acides Nucléiques, DRFMC/SCIB, CEA/Grenoble, Grenoble, France.
9 Type IV Collagen (COL4A1) might play an important role in binding keratinocyte skin stem cells at the dermal-epidermal junction (DEJ)
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23 Frenette PS, Weiss L. Sulfated glycans induce rapid hematopoietic progenitor cell mobilization: evidence for selectin-dependent and independent mechanisms. Mount Sinai School of Medicine, Department of Medicine, New York, NY, USA. Blood. 2000 Oct 1;96(7):2460-8.
24 Sweeney EA, Lortat-Jacob H, Priestley GV, Nakamoto B, Papayannopoulou T. Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells. Department of Medicine, University of Washington, Seattle 98195-7710, USA. Blood. 2002 Jan 1;99(1):44-51.Click here to read
25 Boisson-Vidal C, Zemani F, Caligiuri G, Galy-Fauroux I, Colliec-Jouault S, Helley D, Fischer AM. Neoangiogenesis induced by progenitor endothelial cells: effect of fucoidan from marine algae. INSERM U765, Faculté de Pharmacie 4 av. de l'Observatoire, 75270 Paris cedex 06, France. Cardiovasc Hematol Agents Med Chem. 2007 Jan;5(1):67-77.
26 Mavier P, Martin N, Couchie D, Préaux AM, Laperche Y, Zafrani ES. Expression of stromal cell-derived factor-1 and of its receptor CXCR4 in liver regeneration from oval cells in rat. INSERM U581, Hôpital Henri Mondor, Université Paris XII-Val de Marne, 94010 Créteil, France. Am J Pathol. 2004 Dec;165(6):1969-77.
27 Irhimeh MR, Fitton JH, Lowenthal RM. Fucoidan ingestion increases the expression of CXCR4 on human CD34+ cells. Discipline of Medicine, Clinical School, University of Tasmania, Hobart, Australia. Exp Hematol. 2007 Jun;35(6):989-94.
28 Choi EM, Kim AJ, Kim YO, Hwang JK. Immunomodulating activity of arabinogalactan and fucoidan in vitro. Department of Biotechnology & Bioproducts Research Center, Yonsei University, Seoul, South Korea. J Med Food. 2005 Winter;8(4):446-53.
29 Yang M, Ma C, Sun J, Shao Q, Gao W, Zhang Y, Li Z, Xie Q, Dong Z, Qu X. Fucoidan stimulation induces a functional maturation of human monocyte-derived dendritic cells. Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, People's Republic of China. Int Immunopharmacol. 2008 Dec 20;8(13-14):1754-60. Epub 2008 Sep 8.
30 Feldman SC, Reynaldi S, Stortz CA, Cerezo AS, Damont EB. Antiviral properties of fucoidan fractions from Leathesia difformis. Departamento de Química Orgánica-CIHIDECAR, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Argentina. Phytomedicine. 1999 Nov;6(5):335-40.
31 Hayashi K, Nakano T, Hashimoto M, Kanekiyo K, Hayashi T. Defensive effects of a fucoidan from brown alga Undaria pinnatifida against herpes simplex virus infection. Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Int Immunopharmacol. 2008 Jan;8(1):109-16. Epub 2007 Nov 20.
32 Lee JB, Hayashi K, Hashimoto M, Nakano T, Hayashi T. Novel antiviral fucoidan from sporophyll of Undaria pinnatifida (Mekabu). Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-0194, Japan. Chem Pharm Bull (Tokyo). 2004 Sep;52(9):1091-4.
33 Hayashi T. Studies on evaluation of natural products for antiviral effects and their applications Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Sugitani, Toyama City, Japan. Yakugaku Zasshi. 2008 Jan;128(1):61-79.
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39 Maruyama H, Tamauchi H, Hashimoto M, Nakano T. Antitumor activity and immune response of Mekabu fucoidan extracted from Sporophyll of Undaria pinnatifida. Department of Pathology, School of Allied Health Sciences, Kitasato University, Kitasato 1-15-1, Sagamihara, Kanagawa 228-8555, Japan. In Vivo. 2003 May-Jun;17(3):245-9.
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42 Riou D, Colliec-Jouault S, Pinczon du Sel D, Bosch S, Siavoshian S, Le Bert V, Tomasoni C, Sinquin C, Durand P, Roussakis C. Antitumor and antiproliferative effects of a fucan extracted from ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line. ISOMer (Institut des Substances et Organismes de la Mer), SMAB, Laboratoire de Pharmacologie Marine, Faculté de Pharmacie, Nantes, France. Anticancer Res. 1996 May-Jun;16(3A):1213-8.
43 Alekseyenko TV, Zhanayeva SY, Venediktova AA, Zvyagintseva TN, Kuznetsova TA, Besednova NN, Korolenko TA. Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga. Institute of Physiology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. Bull Exp Biol Med. 2007 Jun;143(6):730-2. 44 Haneji K, Matsuda T, Tomita M, Kawakami H, Ohshiro K, Uchihara JN, Masuda M, Takasu N, Tanaka Y, Ohta T, Mori N. Fucoidan extracted from Cladosiphon okamuranus Tokida induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells. Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan. Nutr Cancer. 2005;52(2):189-201.
45 Haneji K, Matsuda T, Tomita M, Kawakami H, Ohshiro K, Uchihara JN, Masuda M, Takasu N, Tanaka Y, Ohta T, Mori N. Fucoidan extracted from Cladosiphon okamuranus Tokida induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells. Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan. Nutr Cancer. 2005;52(2):189-201.
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Literatura

- Chemistry and Applications of Green Tea by Takehiko Yamamoto, Lekh Raj Juneja, Djoing-Chi Chu, Mujo Kim, L.R. Juneja, D.C. Chu, M. Kim

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